Use of a prediction model for RSV hospitalizations in children born after 33-35 weeks gestation.
Preterm infants have an increased risk of being hospitalized due to RSV infection. During the first year of life in children born with a gestational age between 33 and 36 weeks, there is a risk factor of 3-6 % in the Netherlands. In addition to preterm birth (prematurity), there are associated risk factors that determine the risk of hospitalization due to RSV infection.
A risk scoring model was developed by a Spanish researchers involving eight additional risk factors that are used in parallel. Early indications assert that this model performs well. However, the value of the model for Dutch children is unclear. For example, in Spain (significant exposure to respiratory viruses) is rare. This study is designed to determine the applicability of this prediction model for Dutch children.
With this study, we want to determine if we can predict whether a child will be at risk for severe RSV infection. By investigating the rates of hospitalization during the first year using the risk model we also want to evaluate if the risk factors in the Netherlands are of impact. This provides an important insight into the development of severe RSV infection. In addition, it is conceivable that the risk-scoring model could be used for individualized RSV prevention in preterm infants.
This multicenter prospective cohort study began June 2008. 4555 healthy preterm infants born between 33 and 35 weeks were included, coming from about 40 hospitals throughout the Netherlands.
Parents were asked to fill in a questionnaire shortly after the birth of their child to assess risk factors for RSV in their child. Then at the age of 1 year the family is contacted to establish if the child had been infected in that first year of life with RSV bronchiolitis.
The main results of risk have been published. (Blanken, PloS One 2013)