Driven by recent advances for interrogating the human genome, this research area aims to understand the genetic basis of cardiovascular disease. In addition to the identification of novel gene variants associated with disease, we seek to elucidate the underlying biological mechanisms of disease, and assess the potential for individual prevention.
We are actively participating in a number of collaborative consortia studying the genetic basis of cardiometabolic and vascular disease, including type 2 diabetes, serum lipids and ischemic stroke. Some of our associated faculty play leadership roles in several international consortia studying ischemic stroke (US NIH/NINDS-funded SiGN study), cardiac function (CVON-funded PREDICT study), and imaging/genetics (STW-funded ImaGene study).
In this research area we benefit from strong links with other research areas and patient groups within Circulatory Health.
We are specifically focusing on the following diseases:
Prof. Paul de Bakker
Ruigrok, Koeleman, Spiering, Asselbergs, Bakkers, Cuppen, Doevendans, Dooijes, Hauer