Treatment of patients with stroke (ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage), intracranial vascular malformations (e.g. intracranial aneurysms, arteriovenous malformations and moyamoya), and extracranial vascular pathologies (e.g. stenosis, aneurysms or dissections of the carotid or vertebral arteries) is combined with research. This research encompasses genetic and life style determinants of incidence and outcome of stroke, imaging strategies, phase II and III clinical trials in treatment and secondary prevention, long term outcome assessment including cognitive function and rehabilitation strategies.
Prof. dr. G.J.E. Rinkel
Prof. dr. L.J. Kappelle
Peripheral artery disease patient research group focuses on vessel stenosis, dilatations and rare arterial inflammations in non-coronary vessels. Ninety percent of disorders consist of vessel stenosis and dilatations, causing obstructions and aneurysms. Carotid surgery is among the most important types of surgery performed within this patient group and is increasingly done in a non-invasive manner.
Our Research focuses on:
The patient group Coronary heart disease addresses a broad patient base. Patients with a-symptomatic coronary artery disease, patients with chest pain, myocardial infarctions and cardiac arrests, to patients suffering from severe coronary disease, with heart failure and arrhythmias.
Within this group, our focus lies in the following areas:
The patient group Heart Failure strives toward improvements in the early detection of onset, or worsening heart failure, and its complications (such as arrhythmias) in clinical practice. The importance of co-morbidity in the development, recognition, prognosis and treatment of heart failure, and innovative ways to improve prognosis in all four stages of heart failure such as (new) tele monitoring opportunities, devices and cell therapy.
Basic research focuses on the elucidation of underlying pathways in heart failure, with special emphasis on genetic susceptibility to develop heart failure and the discovery of novel biomarkers, with the aim to improve prevention of new onset or worsening heart failure and to develop novel therapeutic (and monitoring) targets.
The main research interest of the patient group Renal Failure / Hypertension / Elderly focuses on patients with blood pressure-related disorders that are at (high) risk for developing (recurrent) vascular disease: hypertension, renal failure, pregnancy complications and elderly with impaired cognition or mobility.
The patient group High Risk Groups addresses the complex relationship between obesity, insulin resistance, type 2 diabetes and the development of atherosclerosis and clinical manifest vascular diseases. Specific patient groups are patients with type 2 diabetes, metabolic syndrome, poly cystoid ovarian syndrome (PCOS), premature ovarian failure (POF) and patients with HIV.
The common pathophysiology in these patients is insulin resistance and inflammation often is the result of adipose tissue dysfunction. Research topics cover the etiologic relation between dysfunction of the reproductive system and vascular health, (postprandial) lipid metabolism in insulin resistance and obesity-induced systemic inflammation.
Prediction research centers on predicting vascular events in patients with type 2 diabetes. Simultaneously novel therapies to reduce the vascular risk in patients with type 2 diabetes are investigated.
Translational research ranges from basic research including in vitro and ex vivo studies with adipocytes and adipose tissue with emphasis on extra cellular vesicles, inflammation and coagulation.
The group also conducts cohort studies (SMART) and clinical trials with novel therapies (including CETP-inhibition, PCSK9-inhibition, DPP-4 inhibition, IL1β antibody).