CT shows differences in diabetic brain

Patients suffering from diabetes mellitus type 2 show an altered brain structure compared to healthy controls. Using an automated CT-scan comparison technique, PhD-student Cynthia Jongen showed diabetes patients to have a smaller grey matter volume, larger ventricles and more white matter abnormalities.

In her research Jongen also showed differences in infarct locations in people with stenosis of the Internal Carotid Artery (ICA), a partial obstruction of the vessel in the neck that provides the brain with blood. Jongen collected CT images of patients with no or only mild ICA stenosis (0-49%), patients with severe stenosis (50-99%), and patients with an occlusion of the ICA (100%). Patients with an ICA occlusion show other and larger infarcts than patients with a mild or sever stenosis.

Thesis: “Interpatient registration and analysis in clinical neuroimaging”
PhD-advisor: prof. dr. ir. M.A. Viergever
Co-advisor: dr. J.P.W. Pluim