T cells clean up unwelcome intruders like harmful viruses and bacteria, which is why they are important cells in the immune system. Miranda van Berkel compared two similar molecules on the surface of the T cells ICOS and CD28. In addition to CD28, ICOS was also found to play an essential role in the proper functioning of T cells. Van Berkel’s experiments showed that both CD28 and ICOS are involved in the division and survival of these cells. Furthermore, it was found that binding of ICOS generates the same signals as binding of CD28 to T cells. Van Berkel also found that ICOS is essential for the optimal production of antibodies for the Neisseria meningitidis bacteria, even more important than CD28. So, along with CD28, ICOS also forms an interesting objective for immunotherapy: for example, to increase T cell functioning for optimal protection against harmful substances or to inhibit the effects of T cells when they are overactive, as in the case of autoimmune diseases.
Miranda van Berkel
ICOS and CD28: similar or separate costimulators of T cells?
PhD advisor: Prof. Frank Miedema
Co-advisor 1: Dr. Mariette A. Oosterwegel
Co-advisor 2: Dr. Kiki Tesselaar