ABC Neurogenomics and Utrecht Genetics Seminar
(Utrecht Graduate School of Developmental Biology)
A Paradigm Shift in Mouse Genetics: Merging Reductionist and Holistic Approaches to Model Pervasive Diseases in Human Populations
Robert W. Williams, Ph.D.
University of Tennessee Health Science Center
Memphis, USA
The analysis of human disease has profited enormously from systematic application of reductionist methods. But as we learn more about disease susceptibility and interactions of genomes and the environment we realize that much of the final outcome of treatment is due to complex interactions among systems that are essentially irreducible. How do we rigorously model and test such complexity and simultaneously take into account the major role played by genetic variation and marked environmental perturbations, such as the Dutch Hunger Winter, and subtle shifts, such as changes in diet, stress level, and exercise? The problems seem too big to approach.
What is needed is an experimental model system that has the advantages of easily controlled genomes, fully controlled environment, but a genetic complexity and range that more faithfully mirrors human population diversity.
After the seminar refreshments will be served near lecture room
For further information contact: Dr. Edwin Cuppen (030 212 1969)