Genetic detection work in tens of thousands of people has resulted in the discovery of eight genes that contribute either to high or low blood pressure. This has been described by researchers from University Medical Center (UMC) Utrecht together with colleagues from 93 European and American centers in the paper published in the journal Nature Genetics on May 10, 2009. High blood pressure is an important risk factor for cardiovascular disease.
A consortium of 164 researchers analyzed the whole genome of more than 34,000 people for genes that are associated with blood pressure. This study revealed eight genetic variations that are related to either a higher or lower than normal blood pressure. The results were subsequently controlled in 90,000 European and 12,000 Indian people. For this purpose, data from other studies were used. In addition, the data from three UMC Utrecht studies were used: the Leidsche Rijn Health project, the Prospect-EPIC study and the ARYA study.
Each of the eight genetic variants contributes only a very small amount to blood pressure. However, the results widen insight into how high blood pressure occurs and could contribute to the development of new treatments. Incidentally, there is no point in screening for these genes because their effect is too small.
More research is needed in order to find out exactly how these genetic differences can influence blood pressure. The researchers involved in this study think that some genes influence the production of hormones that govern the kidneys. Other genes are involved in how blood vessels can have an influence on blood pressure.
On behalf of University Medical Center (UMC) Utrecht, the following people worked on this study: Professor Rick Grobbee, Dr Charlotte Onland-Moret, Dr Michiel Bots, Dr Cuno Uiterwaal, and Professor Yvonne van der Schouw – and from the Julius Center for Health Sciences and Primary Care, Dr Mattijs Numans.