Henny Otten

Experimental Hematology
Immunology of lung transplantation

@ Henny Otten

Research interest

Chronic rejection after lung transplantation (LTx) leads to the bronchiolitis obliterans syndrome (BOS), wich is,characterized histologically by airway epithelial cell apoptosis and luminal fibrosis in the respiratory bronchioles causing airflow obstruction. BOS is irreversible and is the main cause of morbidity and mortality after LTx. This syndrome occurs also in 5-10% of patients with chronic graft-versus-host disease after stem-cell transplantation (SCT). The main purpose of this study is to identify patients at risk for developing BOS by defining the specificity and function of autoantibodies associated with the onset and pathogenesis of BOS. By this, we aim to identify patients at risk for developing BOS which can be used to guide immunosuppressive therapy after LTx or SCT.

In kidney transplantation, pretransplant risk assessment of graft failure is important for donor selection and choice of immunosuppressive treatment. We are currently engaged in large-scale studies on the clinical relevance of HLA-antibodies, detected by luminex prior to transplantion. In addition, the ability of the transplanted organ to protect itself from complement mediated damage is investigated. 

 

Group Henny Otten

Members

• Kevin Budding, PhD student
• Tineke Hoefnagel, technician

Key publications

Chimerism of dendritic cell subsets in peripheral blood after lung transplantation.
Paantjens AW, van de Graaf EA, Heerkens HD, Kwakkel-van Erp JM, Hoefnagel T, van Kessel DA, van den Bosch JM, Otten HG.
J Heart Lung Transplant. 2011 Jun;30(6):691-7.

Lung transplantation affects expression of the chemokine receptor type 4 on specific T cell subsets.
Paantjens AW, van de Graaf EA, Kwakkel-van Erp JM, Hoefnagel T, van Kessel DA, van den Bosch JM, Otten HG.
Clin Exp Immunol. 2011 Oct;166(1):103-9.

Mannose-binding lectin deficiency linked to cytomegalovirus (CMV) reactivation and survival in lung transplantation.
Kwakkel-van Erp JM, Paantjens AW, van Kessel DA, Grutters JC, van den Bosch JM, van de Graaf EA, Otten HG.
Clin Exp Immunol. 2011 Sep;165(3):410-6.

The Induction of IgM and IgG Antibodies against HLA or MICA after Lung Transplantation.
Paantjens AW, van de Graaf EA, Kwakkel-van Erp JM, Hoefnagel T, van Ginkel WG, Fakhry F, van Kessel DA, van den Bosch JM, Otten HG.
Pulm Med. 2011;2011:432169.

Clara cell secretory protein and surfactant protein-d do not predict bronchiolitis obliterans syndrome after lung transplantation.
Paantjens AW, Otten HG, van Ginkel WG, van Kessel DA, van den Bosch JM, Kwakkel-van Erp JM, van de Graaf EA. 
Transplantation. 2010 Aug 15;90(3):340-2

Lung transplantation under a tacrolimus/mycophenolate mofetil-based immunosuppressive regimen results in low titers of HLA and MICA IgG antibodies which are not related to development of BOS.
Paantjens AW, van de Graaf EA, van Ginkel WG, van den Bosch JM, Otten HG.
J Heart Lung Transplant. 2010 May;29(5):596-8. Epub 2010 Mar 5