Geert Jan Biessels
Department Neurology and neurosurgery
Section Cerebrovascular Disorders Function
Researcher and Neurologist
Tel +31 88 7557975
Project leader of the Utrecht Diabetic Encephalopathy Study (UDES) group and Utrecht Stroke and COGnition study group (USCOG), together with Prof LJ Kappelle Title research line
Vascular risk factors for accelerated cognitive decline Summary research
My research focuses on vascular cognitive impairment. Studies on the nature, pathophysiology and possible treatment of cerebral complications of diabetes mellitus have been a key topic. My current research entails mostly clinical projects with emphasis on neuropsychological studies in relation to state of the art brain imaging techniques and detailed assessment of vascular and metabolic abnormalities.
I currently supervise 6 PhD students on research projects that focus on cognitive functioning and brain imaging in relation to diabetes and cerebrovascular disease.
This involves collaborations with:
• The Helmholtz Institute (Dr RPC Kessels, Prof EH de Haan), the IMAGO researchschool (Prof MA Viergever, Prof WP Mali), and the Julius Centre (Prof A Algra, Prof G Rutten).
• The 'Hoorn Study Group' of the EMGO diabetes-project (Prof RJ Heine, Dr G Nijpels and Dr J Dekker VUMC, Amsterdam).
• The department of neurology of the AMC Amsterdam (Prof M Vermeulen, Dr Y Roos)
• The Alzheimer Centre of the VUMC, Amsterdam (Prof P Scheltens, Dr W van der Flier) Publications
Biessels,GJ, Staekenborg,S, Brunner,E, Brayne,C, Scheltens,P: Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 5:64-74, 2006
Brands,AM, Kessels,RP, Hoogma,RP, Henselmans,JM, van der Beek Boter,JW, Kappelle,LJ, De Haan,EH, Biessels,GJ: Cognitive performance, psychological well-being, and brain magnetic resonance imaging in older patients with type 1 diabetes. Diabetes 55:1800-1806, 2006
Manschot,SM, Brands,AM, van der Grond,J, Kessels,RP, Algra,A, Kappelle,LJ, Biessels,GJ: Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes. Diabetes 55:1106-1113, 2006
van den Berg,E, Biessels,GJ, de Craen,AJ, Gussekloo,J, Westendorp,RG: The metabolic syndrome is associated with decelerated cognitive decline in the oldest old. Neurology 69:979-985, 2007
Biessels,GJ, Deary,IJ, Ryan,CM: Cognition and diabetes: a lifespan perspective. Lancet Neurol 7:184-190, 2008