Name M.M.M. Bulder
Department of Neurology and Neurosurgery
Section Cerebrovascular Disorders
Function MD, PhD-student
E-mail:
M.M.M.Bulder@umcutrecht.nl Tel: +31 88-75 55 555
pager 3834
Supervisors dr. K.P.J. Braun, dr. C.J.M. Klijn, prof. dr. O. van Nieuwenhuizen and prof. dr. L.J. Kappelle
Title research Cerebral perfusion, measured by Arterial Spin Labeling (ASL) perfusion MRI, in relation to outcome in children and young adults with ischemic stroke
Summary research Most children and many young adults with arterial ischemic stroke (AIS) suffer from non-atherosclerotic arterial disease. Childhood arteriopathies may be progressive as in moyamoya disease or non-progressive as in dissection and inflammatory arteriopathies. Arteriopathic stroke has a relatively high recurrence rate, mainly within the first year, and neurological outcome is poor in the majority of children.
Little is known about the association between recurrence rate, outcome and course of arteriopathy, and cerebral perfusion in non-infarcted brain areas.
Arterial Spin Labeling (ASL) perfusion magnetic resonance imaging (MRI) offers the possibility to non-invasively quantify cerebral perfusion and has not yet been applied in young patients with arteriopathic stroke.
HYPOTHESIS
In young patients with stroke and non-atherosclerotic arteriopathy, perfusion deficits in areas outside the infarcted brain compromise cerebral plasticity, and are associated with poor functional outcome, increased risk of recurrent stroke, and unfavourable course of the arteriopathy.