Name Alwin Derijck
Department Neuroscience and Pharmacology
Section Neurodevelopment
Function Post-Doc
E-mail:
a.a.h.a.derijck@umcutrecht.nl tel: +31-(0)88-7568924
Supervisor Dr R.J. Pasterkamp
Title research
Molecular basis of neurite growth
Summary research
The project aims at elucidating the molecular events induced in primary neurons upon stimulation with axon guidance and axon growth promoting proteins. The proteins of current interest are the semaphorins. Several semaphorins have been shown to regulate axon growth but the receptor and signaling mechanisms involved remain largely unknown. However, recent evidence suggests that a complex signaling network exists downstream of semaphorins, regulating transcription and translation to allow for axon growth. To gain further insight into the molecular basis of semaphorin-mediated axon growth ligand-receptor signaling will be addressed at several levels; i) signal transduction pathway, ii) gene transcription, and iii) gene translation.
Publications Derijck AA, van der Heijden GW, Giele M, Philippens ME, van Bavel CC, de Boer P.
gammaH2AX signalling during sperm chromatin remodelling in the mouse zygote.
DNA Repair (Amst). 2006 Aug 13;5(8):959-71.
van der Heijden GW, Derijck AA, Pósfai E, Giele M, Pelczar P, Ramos L, Wansink
DG, van der Vlag J, Peters AH, de Boer P.
Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation.
Nature Genetics 2007 Feb;39(2):251-8
Hatch T, Derijck AA, Black PD, van der Heijden GW, de Boer P, Dubrova YE.
Maternal effects of the scid mutation on radiation-induced transgenerational instability in mice.
Oncogene. 2007 Jul 12;26(32):4720-4. Epub 2007 Jan 29.
Derijck AA, van der Heijden GW, Ramos L, Giele M, Kremer JA, de Boer P.
Motile human normozoospermic and oligozoospermic semen samples show a difference in double-strand DNA break incidence.
Human Reproduction 2007 Sep;22(9):2368-76
Derijck A, van der Heijden G, Giele M, Philippens M, de Boer P.
DNA double strand break repair in parental chromatin of mouse zygotes, the first cell cycle as an origin of de novo mutation.
Human Molecular Genetics 2008 Mar 18; [Epub ahead of print]