Name:
Hessel Franssen
Department Neurology and neurosurgery
Section Neuromuscular diseases
Function:
Associate professor
E-mail:
H.Franssen@umcutrecht.nl Tel: +31 88 7557961
Pager: 3288
Research group:
Neuromuscular research group (Prof. dr L. H. van den Berg, dr N. C. Notermans, ir. L.J. van Schelven)
Title research line:
Motor neuron disease and mimics, including multifocal motor neuropathy (MMN), chronic inflammatory demyelinating polyneuropathy (CIDP), anti-myelin associated glycoprotein (MAG) neuropathy, and chronic idiopathic axonal polyneuropathy.
Summary research:
Role of voltage gated ion channels and Na/K-ATP-ase in the development of axonal degeneration in MMN and CIDP. (Prinses Beatrix Fonds grant no. WAR 06-0116; PhD student drs. D.C.G. Straver).
Electrophysiological aspects of Schwann cell-axon interaction in anti-MAG neuropathy, MMN, and CIDP.
Development and validation of electrodiagnostic criteria for peripheral nerve demyelination and polyneuropathy.
Temperature and peripheral nerve function.
Publications:
(1) Van Asseldonk JTH, Van den Berg LH, Kalmijn S, Wokke JHJ, Franssen H. Criteria for demyelination based on the maximum slowing due to axonal degeneration, determined after warming in water at 37°C: diagnostic yield in chronic inflammatory demyelinating polyneuropathy. Brain 128:880-891(2005).
(2) Van Asseldonk JTH, Van den Berg LH, Wieneke GH, Wokke JHJ, Franssen H. Criteria for conduction block based on computer simulation studies of nerve conduction with human data obtained in the forearm segment of the median nerve. Brain 129:2447-2460 (2006).
(3) Franssen H, Notermans NC. Length-dependence in polyneuropathy associated with IgM gammopathy. Ann. Neurol. 59:365-371(2006).
(4) Vrancken AFJE, Notermans NC, Wokke JHJ, Franssen H. The realistic yield of lower leg SNAP amplitudes and SRAR in the routine evaluation of chronic axonal polyneuropathies. J Neurol 255:1127-1135(2008).
(5) Visser J, de Visser M, Van den Berg-Vos RM, Van den Berg LH, Wokke JH, de Jong JM, Franssen H. Interpretation of electrodiagnostic findings in sporadic progressive muscular atrophy. J Neurol 255: 903-909(2008).