Name:
Mariët van Buuren
Department of Psychiatry
Section Brain changes in developmental disorders
Function:
PhD-student
E-mail:
m.vanbuuren-2@umcutrecht.nl
Tel: +31 88-7558352
Supervisor:
Dr. M. Vink, Prof. R. S. Kahn, MD, PhD
Title research:
Uncovering the genetic basis of brain dysfunction in schizophrenia
Summary research:
Schizophrenia is associated with a number of functional brain deficits, among which are working memory, inhibition, emotional processing, as well as deficits in neural systems that support cognitive functioning. These deficits can be used as biomarkers to facilitate the search of those genes or combinations of genes involved in the development of schizophrenia. The aim of the current study is to link such gene-abnormalities to brain deficits and symptoms associated with schizophrenia. Using functional MRI, 30 schizophrenia patients, 200 siblings of schizophrenia patients, and 30 healthy control subjects will be scanned on five different paradigms known to yield abnormal brain activation in schizophrenia patients. Brain activation will be associated with the various gene-abnormalities (SNPs of candidate genes) as well as with clinical data.
Publications:
M. van Buuren, T.E. Gladwin, B.B. Zandbelt, M. van den Heuvel, N.F. Ramsey, R.S Kahn, M. Vink (2009). Cardiorespiratory effects on default-mode network activity as measured with fMRI. Human Brain Mapping. doi: 10.1002/hbm.20729
B.B. Zandbelt, T.E. Gladwin, M. Raemaekers, M. van Buuren, S.F. Neggers, R.S. Kahn, N.F. Ramsey, M. Vink (2008). Within-subject variation in BOLD-fMRI signal changes across repeated measurements: quantification and implications for sample size. Neuroimage, 42, 196-206.