Name:
Maurits P.A. van Meer
Department Neurology and Neurosurgery
Image Sciences Institute
Function:
MD, PhD-student
E-mail:
maurits@invivonmr.uu.nl
Tel:+31 30-253 5568
Supervisor:
Rick M. Dijkhuizen
Title research:
Pattern and Basis of Functional MRI Signals after Stroke
Summary research:
Functional MRI (fMRI) is increasingly applied as a neuroimaging tool to study changes in activation patterns after stroke. However, the electrophysiological significance of fMRI-detected changes in activation responses after stroke and its underlying structural basis are unresolved. The proposed project is aimed at improving our understanding of the neurophysiological mechanisms that underlie functional recovery after stroke as detected with fMRI. We will apply a rat stroke model in which fMRI methods will be employed to assess brain activation in relation to physiological, structural and molecular changes as determined from parallel MRI, electrophysiology and immunohistochemistry studies. The above studies will provide new and detailed information on the pattern of functional field shifts after stroke, and its underlying neurophysiological and neuroanatomical basis.
Five publications: van Meer MPA, van der Marel K, Otte WM, Berkelbach van der Sprenkel JW, Dijkhuizen RM. Correspondence between altered functional and structural connectivity in the contralesional sensorimotor cortex after unilateral stroke in rats: A combined resting-state functional MRI and manganese-enhanced MRI study. J Cereb Blood Flow Metab 2010 30(10):1707-1711.
van Meer MPA, van der Marel K, Wang K, Otte WM, el Bouazati S, Roeling TAP, Viergever MA, Berkelbach van der Sprenkel JW, Dijkhuizen RM. Recovery of sensorimotor function after experimental stroke correlates with restoration of resting-state interhemispheric functional connectivity. J Neurosci 2010 30(11):3964-3972.
van Meer MPA, Dijkhuizen RM. Functional and structural MR Imaging of brain reorganization after stroke. In: Cramer SC and Nudo RJ, eds. Brain repair after stroke. Cambridge, UK: Cambridge University Press, 2010: p. 57-66.
Wang K, van Meer MPA, van der Marel K, van der Toorn A, Xu L, Liu Y, Viergever MA, Jiang T, Dijkhuizen RM. Temporal scaling properties and spatial synchronization of spontaneous BOLD signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia. NMR Biomed in press.
Kim YR, van Meer MPA, Tejima E, Murata Y, Mandeville JB, Dai G, Chuang DM, Rosen BR and Lo EH. Functional MRI of delayed chronic lithium treatment in rat focal cerebral ischemia. Stroke 2008 39(2):439-447.