Name: Coen Maas
Date of birth: 06-12-1980
Educational background:
Biomedical Sciences, Master Programme Science & Business
Function(s): Post-doctoral researcher
Working at the department since:
15-10-2004
Supervisor(s):
Prof.dr. Ph.G. de Groot
Project(s) you are working on, most important tasks: The role of the intrinsic pathway of coagulation in- and beyond thrombotic disease
Major Publications:
Maas C, Govers-Riemslag JW, Bouma B, Schiks B, Hazenberg BP, Lokhorst HM, Hammarström P, ten Cate H, de Groot PG, Bouma BN, Gebbink MF - Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation - J Clin Invest. 2008 Sep;118(9):3208-18
Maas C, Hermeling S, Bouma B, Jiskoot W, Gebbink MF - A role for protein misfolding in immunogenicity of biopharmaceuticals - J Biol Chem. 2007 Jan 26;282(4):2229-36. Epub 2006 Nov 29
Gebbink MF, Bouma B, Maas C, Bouma BN - Physiological responses to protein aggregates: Fibrinolysis, coagulation and inflammation (new roles for old factors) - FEBS Lett. 2009 Jun 13. [Epub ahead of print]
Maas C, Schiks B, Strangi RD, Hackeng TM, Bouma BN, Gebbink MF, Bouma B - Identification of fibronectin type I domains as amyloid-binding modules on tissue-type plasminogen activator and three homologs - Amyloid. 2008 Sep;15(3):166-80
Bouma B*, Maas C*, Hazenberg BP, Lokhorst HM, Gebbink MF - Increased plasmin-alpha2-antiplasmin levels indicate activation of the fibrinolytic system in systemic amyloidoses - J Thromb Haemost. 2007 Jun;5(6):1139-42. Epub 2007 Feb 20
Hermeling S, Schellekens H, Maas C, Gebbink MF, Crommelin DJ, Jiskoot W - Antibody response to aggregated human interferon alpha2b in wild-type and transgenic immune tolerant mice depends on type and level of aggregation - J Pharm Sci. 2006 May;95(5):1084-96.
What special knowledge of yours could be of interest to your colleagues?
I know some of the rules on the claiming of intellectual property in the Academia.
Besides the intrinsic pathway, I am also interested in
- Liposomal targeting of activated platelets, for drug delivery
- Identification of proteolytic systems that a) contribute to plaque destabilization
b) modulate thrombus formation
Special interests, hobbies: Music, travelling, oudoor activities such as surfing/biking
Email: cmaas4@umcutrecht.nl