Name:
Johan Molling
Date of birth:12-07-1974
Educational background: I was initially trained as a research technician. Later on I obtained my Master’s degree in Medical Biology and a PhD oriented in Tumor Immunology with focus on Invariant Natural Killer T cells and cancer immunotherapy.
Function: Postdoc
Working at the department since:
1-09-2009
Supervisor(s): Henk Lokhorst and Tuna Mutis
Projects you are working on, most important tasks: MAIN PROJECT
Studying, in a humanized mouse model, the therapeutic potential and function of adoptively transferred mHag (CD19L) TCR transduced and Tetanus Toxoid dual specific effector T Cells in the treatment of B cell malignancies.
SIDE PROJECT
Study the relevance of a novel immunoregulatory mechanisms in multiple malignant myeloma
Major publications:
Grauer OM, Molling JW, Bennink E, Toonen LW, Nierkens S, Adema GJ - TLR ligands in the local treatment of established intracerebral murine gliomas - J Immunol. 2008 Nov 15;181(10):6720-9.
Molling JW, Moreno M, van der Vliet HJ, van den Eertwegh AJM, Scheper RJ, von Blomberg BME, Bontkes HJ - Invariant natural killer T cells and immunotherapy of cancer - Clin Immunol. 2008 Nov;129(2):182-94. Review.
Molling JW, Langius JAE, Langendijk JA, Leemans CR, Bontkes HJ, van der Vliet HJ, von Blomberg BME, Scheper RJ, van den Eertwegh AJM - Low levels of circulating invariant natural killer T cells predict poor clinical outcome in patients with head and neck squamous cell carcinoma - J Clin Oncol. 2007 Mar 1;25(7):862-8.
Molling JW, Kolgen W, van der Vliet HJ, Boomsma MF, Kruizenga H, Smorenburg CH, Molenkamp BG, Langendijk JA, Leemans CR, von Blomberg BM, Scheper RJ, van den Eertwegh AJ - Peripheral blood IFN-gamma-secreting Valpha24+Vbeta11+ NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load - Int J Cancer. 2005 Aug 10;116(1):87-93.
What special knowledge of yours could be of interest to your colleagues?(NK)T cell immunology, Mouse models, in vitro culture of (mouse) (Ag specific) T cells, translational research
Special interests, hobbies: Guitar, Chess, my kids
E-mail: J.W.Molling@umcutrecht.nl