Name:
Pieter Vader
Date of birth:
25-04-1985
Educational background:
Chemistry (Bachelor), Drug Innovation (Master)
Function:postdoctoral researcher
Working at the department since:
01-11-2011
Supervisor:
Dr. R.M. Schiffelers
Projects you are working on, most important tasks:
Microvesicle-inspired drug delivery systems
Major publications: 1. P. Vader, B.J. Crielaard, S.M. van Dommelen, R. van der Meel, G. Storm and R.M. Schiffelers. Targeted delivery of small interfering RNA to angiogenic endothelial cells with liposome-polycation-DNA particles. J. Control. Release. (2011). (Epub ahead of print). 2011 Sep 29
2. P. Vader, L.J. van der Aa, J.F.J. Engbersen, G. Storm and R.M. Schiffelers. Physicochemical and biological evaluation of siRNA polyplexes based on PEGylated poly(amido amine)s. Pharm Res. (2011). (Epub ahead of print). 2011 Aug 11
3. P. Vader, R. van der Meel, M.H. Symons, M.H.A.M. Fens, E. Pieters, K.J. Wilschut, G. Storm, M. Jarzabek, W.M. Gallagher, R.M. Schiffelers and A.T. Byrne. Examining the role of Rac1 in tumour angiogenesis and growth: A clinically relevant RNAi-mediated approach. Angiogenesis. 14(4):457-466 (2011).
4. P. Vader, L.J. van der Aa, J.F.J. Engbersen, G. Storm and R.M. Schiffelers. Di-sulfide based poly(amido amine)s for siRNA delivery: Effects of structure on siRNA complexation, cellular uptake, gene silencing and toxicity. Pharm Res. 28(5): 1013-1022 (2011).
5. P. Vader, L.J. van der Aa, J.F.J. Engbersen, G. Storm and R.M. Schiffelers. A method for quantifying cellular uptake of fluorescently labelled siRNA. J. Control. Release. 148(1):106-109 (2010).
What special knowledge of yours could be of interest to your colleagues?Cell culture, drug delivery systems, RNA interference
Special interests, hobbies:
Korfball, golf, squash, guitar playing
E-mail:
P.Vader@umcutrecht.nl