Name: Ray Schiffelers
Date of birth:21-01-1971
Educational background:Bio-Farmaceutische Wetenschappen (Leiden University)
Function:Associate professor
Working at the department since:01-10-2011
Supervisor(s):Prof.dr. W.W. van Solinge
Projects you are working on, most important tasks: - Nanomedicine:
- Function of nanosized extracellular vesicles in blood (vessel) pathophysiology
- Nanosized extracellular vesicles as point of therapeutic intervention
- Nanosized extracellular vesicles as bio-inspired material for drug delivery and tissue engineering
Projects - NWO-STW-Vidi Targeting inflammation to fight cancer 2007-2012
- ERC Starting Grant Microvesicle-inspired drug delivery systems 2010-2015
- ERC Proof of Concept Grant 2011-2012
- NanoNextNL Liposomal Natural Compounds 2012-2016
Major publications: 1. van Rooy I, Mastrobattista E, Storm G, Hennink WE, Schiffelers RM. Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain. J Control Release. 2011 150(1):30-6.
2. Lobatto ME, Fayad ZA, Silvera S, Vucic E, Calcagno C, Mani V, Dickson SD, Nicolay K, Banciu M, Schiffelers RM, Metselaar JM, van Bloois L, Wu HS, Fallon JT, Rudd JH, Fuster V, Fisher EA, Storm G, Mulder WJ. Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis. Mol Pharm. 2010 7(6):2020-9.
3. Coimbra M, Banciu M, Fens MH, de Smet L, Cabaj M, Metselaar JM, Storm G, Schiffelers RM. Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation. J Control Release. 2010 148(3):303-10.
4. Vader P, van der Aa LJ, Engbersen JF, Storm G, Schiffelers RM. A method for quantifying cellular uptake of fluorescently labeled siRNA. J Control Release 2010 148(1):106-9.
5. Fens MH, Storm G, Pelgrim RC, Ultee A, Byrne AT, Gaillard CA, van Solinge WW, Schiffelers RM. Erythrophagocytosis by angiogenic endothelial cells is enhanced by loss of erythrocyte deformability. Exp Hematol. 2010 38(4):282-91.
6. Oliveira S, Høgset A, Storm G, Schiffelers RM. Delivery of siRNA to the target cell cytoplasm: photochemical internalization facilitates endosomal escape and improves silencing efficiency, in vitro and in vivo. Curr Pharm Des. 2008;14(34):3686-97.
7. Fens MH, Hill KJ, Issa J, Ashton SE, Westwood FR, Blakey DC, Storm G, Ryan AJ, Schiffelers RM. Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma. Br J Cancer. 2008 99(8):1256-64.
8. Fens MH, Mastrobattista E, de Graaff AM, Flesch FM, Ultee A, Rasmussen JT, Molema G, Storm G, Schiffelers RM. Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells. Blood. 2008 111(9):4542-50.
What special knowledge of yours could be of interest to your colleagues?Expertise in drug targeting & drug delivery systems/in vivo models of disease/writing grant applications
Special interests, hobbies: Cooking/Gardening/Writing grant applications
E-mail:
R.Schiffelers@umcutrecht.nl