Name:
Flip de Groot
Date of birth:
21-06-1949
Educational background:
Study; Chemistry; PhD: Biochemistry
Function:Head research and education
Working at the department since:
01-02-1984
Supervisor(s):
Prof. Dr. W.W. van Solinge
Projects you are working on, most important tasks:
1. Platelet-vessel wall interactions
Specific aims: To understand the interaction of vWF with collagen at the atomic level.
To understand the conformational changes that convert vWF into its GPIb binding conformation.
2. Auto-immune induced thrombosis
Specific aims To understand why antibodies directed against 2Glycoprotein can cause thrombosis in every vessel within the human body.
To understand the role of LRP8 plays in haemostasis.
To understand the consequences that conformational changes within vWF and GPIb have for the development of thrombotic microangiopathies (but sometimes also haemorrhages).
3. Interaction between haemostasis and inflammation Specific aims:
To understand the role of 2-glycoprotein I, vWF and platelets in inflammation and innate immunity
4. Interaction between clotting factors and platelets Specific aim To understand why factor VIIa prevents bleeding in patients with a platelet function defect.
5. Diagnostic assays to detect an increased risk for thrombosis Specific aims: To improve the diagnosis of the antiphospholipid syndrome.
To improve the diagnosis of thrombotic angiopathies with an assay that recognises vWF in its GPIb binding conformation.
To develop an assay that detects levels of factor VIIa
To develop biomarkers for progression of atherothrombotic disease based on the information that is present in circulating platelets.
Major recent publications:
- Agar C, van Os GM, Mörgelin M, Sprenger RR, Marquart JA, Urbanus RT, Derksen RH, Meijers JC, de Groot PG.(2010) {beta}2-Glycoprotein I can exist in two conformations: implications for our understanding of the antiphospholipid syndrome. Blood 116: 1336-1343
- Romay-Penabad Z, Aguilar-Valenzuela R, Urbanus RT, Derksen RHWM, Pennings MTT, Papalardo E, Shilagard T, Vargas G, Hwang Y, de Groot PG & Pierangeli SS (2011) Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome. Blood, Nov 30 [Epub ahead of print]
- de Laat B, Pengo V, Pabinger I, Musial J, Voskuyl AE, Bultink IE, Ruffatti A, Rozman B, Kveder T, de Moerloose P, Boehlen F, Rand J, Ulcova-Gallova Z, Mertens K, de Groot PG (2009) The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study. Journal of Thrombosis and Haemostasis, 7: 1767-1773
- Pengo V, Tripodi A, Reber G, Rand JH, Ortel TL, Galli M, de Groot PG (2009) Official communication of the scientific and standardization committee on lupus anticoagulant / phospholipid-dependent antibodies: update of the guidelines for lupus anticoagulant detection. Journal of Thrombosis and Haemostasis 7: 1737-1740
- Federici AB, Mannucci PM, Castaman C, Baronciani L, Bucciarelli P, Canciani MT, Pecci A, Lenting PJ, and de Groot PG (2009) Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: A cohort study of 67 patients. Blood 113: 526-34
What special knowledge of yours could be of interest to your colleagues?
Biochemistry
Special interests, hobbies:
Science, history
E-mail:
ph.g.degroot@umcutrecht.nl