Name:
S.J.A. (Suzanne) Korporaal
Educational background:
Bio-Pharmaceutical Sciences
Function:
Post-doctoral Fellow in addition to the Post-doctoral fellow position at Leiden/Amsterdam Center for Drug Research, Division of Biopharmaceutics
Working at the department since:01-02-2000
Supervisor(s):
Dr. M. van Eck (LACDR), Prof. Ph.G. De Groot (LKCH)
E-mail: j.a.korporaal@umcutrecht.nlProjects I am working on, most important tasks, etc.:
The impact of cholesterol metabolism on megakaryopoiesis and platelet production and function.
Major publications:
1. Hoekstra M, Van Eck M, Korporaal SJA. Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I. Curr Opin Lipidol. 2012;23:127-132.
2. Brodde MF, Korporaal SJA, Herminghaus G, Fobker M, Van Berkel TJ, Tietge UJ, Robenek H, Van Eck M, Kehrel BE, Nofer JR. Native high-density lipoproteins inhibit platelet activation via scavenger receptor BI: role of negatively charged phospholipids. Atherosclerosis. 2011;215:374-382.
3. Vergeer M, Korporaal SJA, Franssen R, Meurs I, Out R, Hovingh GK, Hoekstra M, Sierts JA, Dallinga-Thie GM, Motazacker MM, Holleboom AG, Van Berkel ThJC, Kastelein JJP, Van Eck M, Kuivenhoven JA. Genetic variant of the scavenger receptor BI in humans. New Engl J Med. 2011;364:136-145.
4. Korporaal SJA, Meurs I, Hauer AD, Hildebrand RB, Hoekstra M, Ten Cate H, Praticò D, Akkerman JWN, Van Berkel TJ, Kuiper J, van Eck M. Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol. Arterioscler Thromb Vasc Biol. 2011;31:34-42.
5. Hoekstra M, Korporaal SJA, Li Z, Zhao Y, Van Eck M, Van Berkel TJ. Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice. Am J Physiol Endocrinol Metab. 2010;299:E1038-1043.
6. Hildebrand RB, Lammers B, Meurs I, Korporaal SJA, De Haan W, Zhao Y, Kruijt JK, Praticò D, Schimmel AW, Holleboom AG, Hoekstra M, Kuivenhoven JA, Van Berkel TJ, Rensen PC, Van Eck M. Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency. Arterioscler Thromb Vasc Biol. 2010;30:1439-1445.
7. Korporaal SJA, Koekman CA, Verhoef S, van der Wal DE, Bezemer M, Van Eck M, Akkerman JWN. Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2. Arterioscl Thromb Vasc Biol. 2009;29:372-379.
8. Korporaal SJA, van Eck M, Adelmeijer J, Out R, Lisman JA, Lenting PJ, van Berkel ThJC, Akkerman JWN. Platelet activation by oxidized low-density lipoprotein is mediated by CD36 and scavenger receptor-A. Arterioscl Thromb Vasc Biol. 2007;27:2476-83.
9. E Herczenik, B Bouma, SJA Korporaal, R Strangi, Q Zeng, P Gros, M Van Eck, ThJC Van Berkel, M Gebbink, JWN Akkerman. Activation of human platelets by misfolded proteins. Arterioscl Thromb Vasc Biol. 2007;27:1657-65.
10. Korporaal SJA, Akkerman JWN. Lipoprotein-associated proteins involved in platelet signaling. Pathophysiol Haemost Thromb. 2006;35:305-13.
11. Korporaal SJA, Akkerman JWN. Platelet activation by low density lipoprotein and high density lipoprotein. Pathophysiol Haemost Thromb. 2006;35:270-80.
12. Korporaal SJA, Akkerman JWN. Platelet signaling induced by lipoproteins and the development of thrombosis and atherosclerosis. Cardiovasc Hematol Agents Med Chem. 2006;4:93-109.
13. Korporaal SJA, Gorter G, van Rijn HJM, Akkerman JWN. The effect of oxidation on the platelet-activating properties of low-density lipoprotein. Arterioscl Thromb Vasc Biol. 2005;25:867-872.
14. Korporaal SJA, Relou IAM, van Eck M, Strasser V, Bezemer M, Gorter G, van Berkel ThJC, Nimpf J, Akkerman JWN, Lenting P. Binding of low-density lipoprotein to platelet apolipoprotein E receptor 2’ results in phosphorylation of p38MAPK. J Biol Chem. 2004;279:52526-52534.
15. Korporaal SJA, Relou IAM, van Rijn HJM, Akkerman JWN. Lysophosphatidic acid-independent platelet activation by low-density lipoprotein. FEBS Lett. 2001;494:121-124.