Type I diabetes (T1D) is a complex disorder in which multiple genes interact with environmental factors leading to severe disease phenotype. T1D damages several organs including kidneys, liver, vessels, nerves and brain, and eyes. Chronic debilitation and blindness are among the most common severe complications caused by T1D.
Our research line is studying the genetic factors of T1D as an immune-system associated disease. We have integrated several disciplines, including clinical, immunological, genetics, biostatistics methods, and advanced laboratory techniques to investigate the complex genetic architecture of T1D. We perform candidate gene association studies, as well as extensive genome sequencing to locate the T1D-associated genetic markers.
Contact:
Dr. Bobby Koeleman