Vesico-Ureteral Reflux (VUR) is a congenital anomaly of the urinary tract that occurs in 1% of newborns. Children with this anomaly have an increased chance of ascending urinary tract infections and kidney damage. 10% to 30% of patients' siblings are also affected. We are therefore preparing both a linkage and an association study of children who have been operated upon in university hospitals. We hope to gain insight into the epidemiology and aetiology of this complex phenotype and to improve diagnostic procedures.
As a spin-off study, we want to use sequencing to investigate the role of a candidate gene for renal a-/dysplasia in a select group of patients from the genetics clinic.
Contact:
Dr. Jacques Giltay, MD
If you would like to know more about this disorder or the research, or if you think your family could participate, or if you are a doctor and would like to register a patient, please contact one of the following:
- Drs. A.M. van Eerde, specialist in training
- Dr. E. van Riel, genetic consultant
- Dr. J.C. Giltay, clinical geneticist
email: vur@umcutrecht.nl
telephone: +31 (0)88 - 7553800
Postal addres:
DBG afdeling Medische Genetica
Refluxonderzoek
huispost KC04.084.2
Antwoordnummer 58755
3508 WH Utrecht