Gene Tests (by indication)

Below is the complete list of Gene Tests currently performed by our DNA diagnostic laboratory (last update: October 4th, 2011) 

Notes:

1. For DNA-diagnostics of Epilepsy and Primary Immunodeficiencies please see the separate tables (at bottom of page)

2. For Indications not listed here, please consult the LOD-website (www.dnadiagnostiek.nl), which features a complete list of Gene Tests offered by DNA diagnostic laboratories within The Netherlands. 


GENE TESTS (by indication)

INDICATION GENE
22q11 microdeletion syndrome, VCFS [22Q11]
Acromegaly, pituitary adenoma predisposition AIP
Adrenal deficiency, DSD, POF NR5A1
Adrenal hypoplasia, X-linked, AHC NR0B1
Albright hereditary osteodystrophy, AHO GNAS
Amyloidosis I and VII; transthyretin amyloidosis TTR
Amyotrophic lateral sclerosis type 1, ALS1 SOD1
Amyotrophic lateral sclerosis type 4, ALS4 SETX
Amyotrophic lateral sclerosis type 6, ALS6 FUS
Amyotrophic lateral sclerosis type 8, ALS8 VAPB
Amyotrophic lateral sclerosis type 9, ALS9 ANG
Amyotrophic lateral sclerosis type 10, ALS10 TARDBP
Amyotrophic lateral sclerosis type 11, ALS11 FIG4
Angelman syndrome [AS]
Arrhythmogenic right ventricular dysplasia, ARVD/C 1 TGFB3
Arrhythmogenic right ventricular dysplasia, ARVD/C 5 TMEM43
Arrhythmogenic right ventricular dysplasia, ARVD/C 8 DSP
Arrhythmogenic right ventricular dysplasia, ARVD/C 9 PKP2
Arrhythmogenic right ventricular dysplasia, ARVD/C 10 DSG2
Arrhythmogenic right ventricular dysplasia, ARVD/C 11 DSC2
Arrhythmogenic right ventricular dysplasia, ARVD/C 12 JUP
Arrhythmogenic right ventricular dysplasia PLN
Azoospermia; severe oligozoospermia, AZF [AZF]
Biotidinase deficiency BTD
Blau syndrome NOD2
Branchio-oto-renal syndrome type 2 SIX5
Branchio-oto-renal syndrome type 3 SIX1
Breast cancer, hereditary, BRCA1 BRCA1
Breast cancer, hereditary, BRCA2 BRCA2
Cataract and dilating cardiomyopathy, CRYAB CRYAB
Cholestasis, familial intrahepatic 1, PFIC1 ATP8B1
Cholestasis, familial intrahepatic 2, PFIC2 ABCB11
Cholestasis, familial intrahepatic 2, PFIC3 ABCB4
CINCA syndrome NLRP3
Currarino triad, TRIAD HLXB9
DIRA syndrome IL1RN
Fabry disease; alpha-galactosidase A deficiency, FABRY GLA
Fallot, Tetralogy of, TOF NKX2-5
Familial cold auto inflammatory syndrome 1, FCAS1 NLRP3
Familial cold auto inflammatory syndrome 1, FCAS2 NLRP12
Familial mediterranean fever, FMF MEFV
Familial myeloid malignancy CEBPA
Familial platelet disorder, with associated myeloid malignancy RUNX1
Fraser syndrome FRAS1
Fraser syndrome FREM2
Fraser syndrome / MOTA / BNAR FREM1
Fraser syndrome GRIP1
Hyperglycerolemia GK
Hemochromatosis HFE
Hemophilia A, HEMA F8
Hyper-IgD syndrome, HIDS MVK
Hyperparathyreoidism, familial primary, HRPT1 MEN1
Hypodontia, familial, HYD1 MSX1
Hypodontia, familial, HYD3 PAX9
Hypodontia, familial WNT10A
Inflammatory bowel disease, type 28 IL10RA
Inflammatory bowel disease, type 25 IL10RB
Joubert syndrome type 3, JBTS3 AHI1
Joubert syndrome type 4, JBTS4 NPHP1
Kennedy disease; SBMA, X-linked type 1, SBMA, SMAX1 AR
Lesch-Nyhan syndrome, LNS HPRT1
Lynch syndrome, HNPCC2 MLH1
Lynch syndrome, HNPCC1 MSH2
Lynch syndrome, HNPCC5 MSH6
Medium-chain acyl-coA dehydrogenase deficiency, MCAD ACADM
Metachromatic leukodystrophy, MLD ARSA
Mevalonate kinase deficiency, MKD MVK
Microsatellite instability test [MSI]
Microvillus inclusion disease with diarrhea, MVID, DIAR2 MYO5B
Muckle-Wells syndrome NLRP3
Multiple endocrine neoplasia type 1A, MEN1 MEN1
Multiple endocrine neoplasia type 2A, MEN2A RET
Multiple endocrine neoplasia type 4, MEN4 CDKN1A
Multiple endocrine neoplasia type 4, MEN4 CDKN1B
Multiple endocrine neoplasia type 4, MEN4 CDKN2B
Multiple endocrine neoplasia type 4, MEN4 CDKN2C
Myotonic dystrophy type 1, DM1 DMPK
Myotonic dystrophy type 2, DM2 ZNF9
Nephronophthisis type 1 NPHP1
Nephronophthisis type 3 NPHP3
Obesity LEP
Obesity LEPR
Obesity PCSK1
Obesity POMC
Oligodontia/hypodontia AXIN2
Oligodontia/hypodontia IRF6
Oligodontia/hypodontia SUMO1
Oligodontia/hypodontia TBX22
Oligodontia-colorectal cancer syndrome AXIN2
PAPA syndrome PSTPIP1
Papillary renal cell carcinoma, PRC MET
Phenylketonuria type 1. Phenylalanine hydroxylase deficiency, PKU PAH
Phenylketonuria type 3. 6-pyruvoyl tetrahydro pterin synthase deficiency, PTPS PTS
Pheochromocytoma/paraganglioma, hereditary SDHB
Pheochromocytoma/paraganglioma, hereditary SDHC
Pheochromocytoma/paraganglioma, hereditary SDHD
Pheochromocytoma/paraganglioma, hereditary TMEM127
Polyneuropathy, amyloid TTR
Pompe disease, GSD2 GAA
Phosphoglycerate dehydrogenase deficiency PHGDH
Prader-Willi syndrome, PWS [PWS]
Premature ovarian failure, POF FMR1
Pseudohypoparathyroidism type 1a, PHP1a GNAS
Pyruvate kinase deficiency, PK PKLR
Renal coloboma syndrome PAX2
Renal adysplasia UPK3A
Rendu, Osler and Weber syndrome, HHT1 ENG
Rendu, Osler and Weber syndrome, HHT2 ACVRL1
Rendu, Osler and Weber syndrome, JPHT SMAD4
Rett syndrome, RTT MECP2
Rett syndrome, atypical CDKL5
Rett syndrome, atypical MEF2C
Schizencephaly EMX2
Spinocerebellar ataxia, autosomal dominant, SCA1 ATXN1
Spinocerebellar ataxia, autosomal dominant, SCA2 ATXN2
Spinocerebellar ataxia, autosomal dominant, SCA3 ATXN3
Spinocerebellar ataxia, autosomal dominant, SCA6 CACNA1A
Spinocerebellar ataxia, autosomal dominant, SCA7 ATXN7
Spinocerebellar ataxia, autosomal dominant, SCA12 PP2R2B
Spinocerebellar ataxia, autosomal dominant, SCA13 KCNC3
Spinocerebellar ataxia, autosomal dominant, SCA14 PRKCG
Spinocerebellar ataxia, autosomal dominant, SCA17 TBP
Spinocerebellar ataxia, autosomal dominant, SCA23 PDYN
Spinocerebellar ataxia, autosomal dominant, SCA28 AFG3L2
Sporadic medullary thyroid carcinoma, MTC MTC
Tumor necrosis factor receptor-associated periodic fever syndrome, TRAPS TNFRSF1A
Tyrosinemia type 1, HT1 FAH
Uniparental disomy, chromosome... [MARK]
Vesicoureteral reflux1; VUR1 PAX2
Von Hippel-Lindau disease VHL
Van der Woude syndrome, VWS IRF6
Wilson Disease, WD ATP7B
X-chromosome inactivation AR
Zygosity test [X2Y]

EPILEPSY

INDICATION GENE
Autosomal dominant lateral temporal lobe epilepsy, ADLTE, LGI1 LGI1
Benign familial neonatal convulsions, BFNC KCNQ2
Benign familial neonatal convulsions, BFNC KCNQ3
Benign familial neonatal-infantile seizures, BFNIS SCN2A
Female ristricted epilepsy with mental retardation, EFMR PCDH19
Generalized epilepsy with febrile seizures plus, GEFS+ SCN1A
Generalized epilepsy with febrile seizures plus, GEFS+ SCN1B
Generalized epilepsy with febrile seizures plus, GEFS+ SCN2A
Generalized epilepsy with febrile seizures plus, GEFS+ GABRG2
Epileptic encephalopathy, early infantile 2 CDKL5
Noctural frontal lobe epilepsy, type 1, ADNFLE1 CHRNA4
Noctural frontal lobe epilepsy, type 3, ADNFLE3 CHRNB2
Progressive myoclonic epilepsy type 1 (EPM1) CSTB
Progressive myoclonic epilepsy type 2A / lafora body disease EPM2A
Progressive myoclonic epilepsy type 2B / lafora body disease NHLRC1
Progressive myoclonic epilepsy type 3, EPM3 KCTD7
Progressive myoclonic epilepsy type 4, EPM4 SCARB2
Pyrodoxin-dependent epilepsy, PDE ALDH7A1
Pyrodoxin-dependent epilepsy, PDE PNPO
Severe myoclonic epilepsy of infancy, SMEI, SCN1A SCN1A
Unverricht-Lundborg disease, EPM1 CSTB

PRIMARY IMMUNODEFICIENCIES (only after consultation)

INDICATION GENE
Agammaglobulinemia, X-linked, XLA BTK
Autoimmune lymphoproliferative syndrome; ALPS, type 1a FAS
Autoimmune lymphoproliferative syndrome; ALPS, type 1b FASL
Autoimmune lymphoproliferative syndrome; ALPS, type 2a CASP10
Hemophagocytic lymphohistiocytosis, familial; HLH type 2 PRF1
Hemophagocytic lymphohistiocytosis, familial; HLH type 3 UNC13D
Hemophagocytic lymphohistiocytosis, familial; HLH type 4 STX11
Hemophagocytic lymphohistiocytosis, familial; HLH type 5 STXBP2
Immunodeficiency with hyper-IgM, CD40 ligand deficiency CD40LG
Immunodeficiency with hyper-IgM, AID deficiency AICDA
ICOS deficiency ICOS
Severe combined immunodeficiency; X-linked SCID IL2RG
Severe combined immunodeficiency; SCID JAK3
Severe combined immunodeficiency; SCID ZAP70
Severe combined immunodeficiency; SCID CD3G
Severe combined immunodeficiency; SCID CD3D
Severe combined immunodeficiency; SCID CD3E
Wiskott-Aldrich syndrome WAS
Lymphoproliferative syndrome, type 1, XLP1 SH2D1A
Lymphoproliferative syndrome, type 2, XLP2 XIAP













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