The role of the IGF system and glucocorticoids in the regulation of growth

Recent publications:

• Koedam, J. A., C. M. Hoogerbrugge, S. C. van Buul-Offers. Insulin-like growth factor-binding protein-3 protease activity in Snell normal and Pit-1 deficient dwarf mice. J. Endocrinol. 157:295-303 (1998).
• Rooman, R., J. G. Koster, R. J. Bloemen, M. G. Gresnigt, S. C. van Buul-Offers. The effect of dexamethasone on body and organ growth of normal and IGF-II transgenic mice. J. Endocrinol. 163:543-552 (1999).
• Smink, J. J., J. G. Koster, B. I. Hendriks-Stegeman, S. C. van Buul-Offers. Insulin-like growth factor II-induced changes in expression of IGF binding proteins in lymphoid tissues of hIGF-II transgenic mice. Endocrinology 140:5876-5882 (1999).
• van Buul-Offers, S. C., M. van Kleffens, J. G. Koster, D. J. Lindenbergh-Kortleve, M. G. Gresnigt, S. L. S. Drop, C. M. Hoogerbrugge, R. J. Bloemen, J. A. Koedam, J. W. van Neck. Human insulin-like growth factor (IGF) binding protein-1 inhibits IGF-I-stimulated body growth but stimulates growth of the kidney in Snell dwarf mice. Endocrinology 141: 1493-1499 (2000).
• Koedam, J. A., C. M. Hoogerbrugge, S. C. van Buul-Offers. Differential regulation of insulin-like growth factor binding proteins in rabbit costal chondrocytes by IGF-I and dexamethasone. J. Endocrinol. 165: 557-567 (2000).
• van Kleffens, M., D.J. Lindenbergh-Kortleve, J.G. Koster, J.W. van Neck, A. Flyvbjerg, R. Rasch, S.L.S. Drop, S.C. van Buul-Offers. The role of the IGF axis in IGFBP-1 and IGF-I induced renal enlargement in Snell dwarf mice. J. Endocrinol. 170: 333-346 (2001).
• Smink, J.J., J.G. Koster, M.G. Gresnigt, R. Rooman, J.A. Koedam, S.C. van Buul-Offers. IGF and IGF-binding protein expression in the growth plate of normal, dexamethasone-treated and human IGF-II transgenic mice. J.Endocrinol. 175:143-153 (2002).
• Smink, J.J., J.A. Koedam, J.G. Koster, S.C. van Buul-Offers. Dexamethasone-induced growth inhibition of porcine growth plate chondrocytes is accompanied by changes in levels of IGF axis components. J. Endocrinol. 174:343-352 (2002).
• Koedam, J.A., J.J. Smink, S.C. van Buul-Offers. Glucocorticoids inhibit vascular endothelial growth factor expression in growth plate chondrocytes. Mol. Cell. Endocrinol. 197:35-44 (2002).
• Smink, J.J., M.G. Gresnigt, N. Hamers, J.A. Koedam, R. Berger, S.C. van Buul-Offers. Short-term glucocorticoid treatment of prepubertal mice decreases growth and IGF-I expression in the growth plate. J. Endocrinol. 177:381-388 (2003).
• Smink, J.J., I.M. Buchholz, N. Hamers,C.M. van Tilburg, C. Christis, R.J. Sakkers, K. de Meer, S.C. van Buul-Offers, J.A. Koedam. Short-term glucocorticoid treatment of piglets causes changes in growth plate morphology and angiogenesis. Osteoarthritis Cartilage 11:864-871 (2003).
• Rooman, R.P., G. Kuijpers, R. Gresnigt, R. Bloemen, J.G. Koster, S.C. van Buul-Offers. Dexamethasone differentially inhibits thyroxine- or growth hormone-induced body and organ growth of Snell dwarf mice. Endocrinology 144:2553-2558 (2003).
• Vermeer, H., B.I. Hendriks-Stegeman, B. van der Burg, S.C. van Buul-Offers, M. Jansen. Glucocorticoid-induced increase in lymphocytic FKBP51 mRNA expression: a potential marker for glucocorticoid sensitivity, potency and bioavalability. J. Clin. Endocrinol. Metab. 88:277-284 (2003).
• Vermeer, H., B.I. Hendriks-Stegeman, C.E. van den Brink, P.T. van der Saag, B. van den Burg, S.C. van Buul-Offers, M. Jansen. A novel specific bioassay for the determination of glucocorticoid bioavailability in human serum. Clin. Endocrinol. 59:49-55 (2003).
• Vermeer, H., B.I. Hendriks-Stegeman, D. van Suylekom, G.T. Rijkers, S.C. van Buul-Offers, M. Jansen. An in vitro bioassay to determine individual sensitivity to glucocorticoids: induction of FKBP51 mRNA in peripheral blood mononuclear cells. Mol. Cell. Endocrinol. 218:49-55 (2004).
• Vermeer, H., B.I. Hendriks-Stegeman, A.A. Verrijn Stuart, S.C. van Buul-Offers, M. Jansen. A comparison of in vitro bioassays to determine cellular glucocorticoid sensitivity. Eur. J. Endocrinol. 150:41-47 (2004).
• van Buul-Offers, S.C., J.J. Smink, R. Gresnigt, N. Hamers, J. Koedam, M. Karperien. Thyroid hormone, but not parathyroid hormone, partially restores glucocorticoid-induced growth retardation. Pediatr. Nephrol. 20:335-341 (2005).