Publications

2011

Vercoulen Y, Guichelaar T, Meerding J, Emmelot M, Pingen M, Storm G, Coffer P, Sawitzki B, Martens A, Mutis T, Prakken B. Application of cultured human regulatory T cells requires preclinical in vivo evaluation. J Allergy Clin Immunol. 2011 Dec 9. [Epub ahead of print]

van der Vos KE, Gomez-Puerto C, Coffer PJ. Regulation of autophagy by Forkhead box (FOX) O transcription factors. Adv Enzyme Regul. 2011 Nov 10. [Epub ahead of print]

Beekman JM, Vervoort SJ, Dekkers F, van Vessem ME, Vendelbosch S, Brugulat-Panès A, van Loosdregt J, Braat AK, Coffer PJ. Syntenin-mediated regulation of Sox4 proteasomal degradation modulates transcriptional output. Oncogene. 2011 Oct 10. doi: 10.1038/onc.2011.445. [Epub ahead of print]

Visser G, de Jager W, Verhagen LP, Smit GP, Wijburg FA, Prakken BJ, Coffer PJ, Buitenhuis M. Survival, but not maturation, is affected in neutrophil progenitors from GSD-1b patients. J Inherit Metab Dis. 2011 Aug 24. [Epub ahead of print]

Wehrens EJ, Mijnheer G, Duurland CL, Klein M, Meerding J, van Loosdregt J, de  Jager W, Sawitzki B, Coffer PJ, Vastert B, Prakken BJ, van Wijk F. Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells. Blood. 2011 Sep 29;118(13):3538-48.

Cardoso BA, de Almeida SF, Laranjeira AB, Carmo-Fonseca M, Yunes JA, Coffer PJ, Barata JT. TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells. Leukemia. 2011 Oct;25(10):1578-86.

van de Laar L, van den Bosch A, Wierenga AT, Janssen HL, Coffer PJ, Woltman AM. Tight control of STAT5 activity determines human CD34-derived interstitial dendritic cell and langerhans cell development. J Immunol. 2011 Jun
15;186(12):7016-24.

van Loosdregt J, Brunen D, Fleskens V, Pals CE, Lam EW, Coffer PJ. Rapid temporal control of Foxp3 protein degradation by sirtuin-1. PLoS One. 2011 Apr 20;6(4):e19047.

2010

van de Laar, L., van den Bosch, A., van der Kooij, S.W., Janssen, H.L., Coffer, P.J., van Kooten, C. and Woltman, A.M. A non-redundant role of canonical NFkB in human myeloid dendtric cell deveopment and function. J. Immunol, in press

Steevals, T.A.M., Westerlaken, G.H.A., Tijssen, M.R., Coffer, P.J., Lenting, P., Akkerman, J-W.N. and Meyaard, L. Co-expression of receptors Leukocyte-Associated Ig-like Receptor-1 and Glycoprotein VI on a subset of megakaryoblasts. Hematologica, in press

van der Vos, K. and Coffer, P.J. The extending network of FOXO transcriptional target genes.  Antioxidants & Redox Signaling, in press

Buitenhuis, M., van der Linden, E., Ulfman, L., Hofhuis, F., Bierings, M. and Coffer, P.J. (2010) Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties. Blood 116, 2373-2384

Bartels, M., Geest, C.R., Bierings, M., Buitenhuis, M. and Coffer, P.J. (2010) Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation. Hematologica 95, 1052-106

van der Laar, L., Buitenhuis, M., Wensveen, F.M., Janssen, H.L.A., Coffer, P.J. and Woltman, A.M. (2010) Human CD34-derived myeloid dendritic cell development requires intact PI3K-PKB-mTOR signaling. J. Immunol. 184, 6600-6611

Bakema, J.E., Hiemstra, I.H., Bakker, J., de Haij, S., Kok, Y., Adema, G., van Egmond, M., Coffer PJ, van de Winkel and J.G., Leusen, J.H. (2010) JAB1 binds to the IgA receptor and modulates protein levels of FcalphaRI and FcR gamma-chain. Eur J Immunol. 40, 1-6

van Loosdregt, J., Vercoulen, Y, Guichelaar, T, van Gent, Y.J., Beekman, J.M., van Beekum, O., Brenkman, A., Hijnen, D., Mutis, T., Kalkhoven, E., Prakken, B.J. and Coffer, P.J. (2010) Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood 115, 965-974
 
Steevels, T.A., Lebbink, R.J., Westerlaken, G.H., Coffer PJ and Meyaard, L. (2010) Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes. J. Immunol. 184, 4741-4748.

2009

Beekman, J.M., Verhagen, L.P., Geijsen, N. and Coffer, P.J. (2009) Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output. Blood 114, 3917-3927

Geest, C.R., Buitenhuis, M., Groot-Koerkamp, M.J., Holstege, F.C., Vellenga, E., Coffer, P.J..Tight control of MEK-ERK activation is essential in regulating proliferation, survival and cytokine production of CD34 derived neutrophil progenitors. Blood 114, 3402-3412

Geest, C.R., Buitenhuis, M., Laarhove, A.G., Bierings, M.B., Bruin, M.C.A., Vellenga, E. and Coffer, P.J. (2009) p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBP on serine 21. Stem Cells 27, 2271-2282

Geest, C.R., Buitenhuis, M., Vellenga, E. and Coffer, P.J. (2009) Ectopic expression of C/EBPa and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia. Haematologica 94, 1075-1084

Geest, R.C., Zwartkruis, F.J., Vellenga, E., Coffer, P.J. and Buitenhuis, M. (2009) mTOR activity is required for expansion of CD34 hematopoietic progenitor cells. Haematologica 94, 901-1000

Coffer, P.J. (2009) When less is more: the PI3K pathway as a determinant of tumor response to dietary restriction. Cell Res. 19, 797-799

de Jager, W., Vastert, S.B., Beekman, J.M., Wulffraat, N.M., Kuis, W., Coffer, P.J. and Prakken, B.J. (2009) Defective phosphorylation of the IL-18 receptor causes impaired NK cell function in systemic onset juvenile idiopathis arthritis. Arthritis & Rhematism 60, 2782-2793

Essaghir, A, Dif N, Marbehant, CY, Coffer, PJ and Demoulin JB. (2009) The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J. Biol. Chem. 284, 10334-10342

van Gorp, A.G.M., van der Vos, K., Brenkman, A.B., Bremer, A., van den Broek, N., Zwartkruis, F., Hershey, J.W., Burgering, B.M.T., Calkhoven, C.F. and Coffer, P.J. (2009) AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B. Oncogene 28, 95-106

Buitenhuis, M. and Coffer, P.J. (2009) The role of the PI3K-PKB signalling module in the regulation of hematopoieis. Cell Cycle 8, 560-566

2008

Kuijk, L.M., Beekman, J.M., Waterham, H.R., Frenkel, J. and Coffer, P.J. HMG-CoA reductase inhibition induces IL-1b release through Rac1/PI3K/PKB-dependent caspase-1 activation. Blood 112, 3563-3573

Buitenhuis, M., Verhagen, L.P., van Deutekom, H.W., Castor, A., Verploegen, S., Koenderman, L., Jacobsen, S.E. and Coffer, P.J. (2007) Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis. Blood 111, 112-121

The ins-and-outs of syntenin, a multifunctional adapter protein. Beekman, J. and Coffer, P.J. (2008) J. Cell Sci. 121, 1349-1355

FOXO binding partners: it takes two-to tango. van der Vos, K.A. and Coffer, P.J. (2008) Oncogene 27, 2289-2299

2007

Coffer, P.J. and Burgering, B.M.T. (2007) Stressed in the marrow: FoxOs stem tumour growth. Nature Cell Biol. 9, 251-253

Fuhler, G.M., Drayer, A.L., Olthof, S.G., Schuringa, J.J., Coffer, P.J. and Vellenga, E. (2207) Reduced activation of protein kinase B, Rac and F-actin polymerisation contribute to impairment of SDF-1 induced migration of CD34 cells from patients with myelodysplasia. Blood 111, 359-368

Buitenhuis, M., Verhagen, L. P., Cools, J. and Coffer, P.J. (2007) Molecular Mechanisms underying FIP1L1-PDGFRA mediated myeloproliferation. Cancer Res. 67, 3759-3766

Birkenkamp, K.U., Essafi, A., van der Vos, K., da Costa, M., Hui, R. C-Y., Holstege, F., Koenderman, L., Lam, E. W-F. and Coffer, P.J. (2007) FOXO3a induces differentiation of Bcr-Abl transformed cells through transcriptional down-regulation of Id1. J. Biol. Chem. 282, 2211-2220

Fuhler, G.M., Blom, N.R., Coffer, P.J., Drayer, A.L. and Vellenga, E. (2007) The reduced GM-CSF priming of ROS production in granulocytes from patients with myelodysplasia is associated with impaired lipid raft formation. J. Leuk. Biol. 81, 449-457

2006

van Gorp, A.G.M., Pomeranz, K.M., Birkenkamp, K.U., Hui, R. C-Y., Lam, E. W-F. and Coffer, P.J. (2006) Chronic protein Kinase B (PKB/c-akt) activation leads to apoptosis induced by ROS-mediated Foxo3a transcriptional upregulation. Cancer Res. 66, 10760-20769

Rosas, M., Dijkers, P.F., Lindemans, C.A., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (2006) IL-5-mediated eosinophil survival requires inhibition of GSK-3 and correlates with beta-catenin relocalization. J. Leuk. Biol. 80, 186-195

Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NFkB-dependent mechanism. Lindemans, C.A., Coffer, P.J., Schellens, I.S., de Graaff, P.M.A., Kimpen, J.L.L. and Koenderman, L. (2006) J. Immunol. 176, 5529-5537

Verbrugge, A, de Ruiter, T., Geest, C., Coffer, P.J. and Meyaard, L. Differential expression of Leukocyte Associated Ig-like Receptor-1 during neutrophil differentiation and activation. (2006) J. Leuk. Biol. 79, 828-836

2005

Verploegen, S., Ulfman, L., van Deutekom, H., van Aalst, C., Honing, H., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (2005). Characterization of the role of CaMKI Like Kinase (CKLiK) in human granulocyte function. Blood 106, 1076-1083

Real, P.J., Benito, A., Cuevas, J., Berciano, M.T., de Juan, A., Coffer, P.J., Gomez-Roman, J.,  Larfaga, M., lopez-Vega, J.M. and Fernandez-Luna, J.L. (2005) Blockade of epidermal growth factor receptors chemosensitizes breast cancer cells through upregulation of Bnip3L. Cancer Res. 65, 8151-8157

Buitenhuis, B., van Deutekom, H.W.M., Verhagen, L.P., Castor, H., jacobsen, S.E., lammers, J-W.J., Koenderman, L. And Coffer, P.J. (2005) Differential regulation of granulopoiesis by the basic Helix Loop Helix transcriptional inhibitors Id1 and Id2. Blood 105, 4272-4281

Oudijk, E-J.D., Nijhuis, E.H.J., Zwank, M.D., van de Graaf, E. A., Mager, H.J., Coffer, P.J., Lammers, J-W.J. and Koenderman, L. (2005) Systemic inflammation in COPD visualized by gene profiling in peripheral blood neutrophils. Thorax 60, 438-544

Liu, J.W., Chandra, D., Rudd, M.D., Butler, A.P., Pallotta, V., Brown, D., Coffer, P.J. and Tang, D.G. (2005) Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS. Oncogene 24, 2020-2031

Rosas, M., Birkenkamp, K.U., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (2005) Cytokine mediated suppression of TF-1 apoptosis requires PI3K activation and Bim expression. FEBS Letts. 579, 191-198

2004

Fernandez ed Mattos, S., Essafi, A., Soeiro, I., Pietersen, A.M., Birkenkamp, K.U., Edwards, C.S., martino, A., Nelson, B.H., Francis, J.M., Brosens, J.J., Coffer, P.J. and Lam, E. W-F. (2004) FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol. Cell. Biol. 24, 10058-10071

Phosphatidylinositol 4-kinase beta is critical for functional association of rab11 with the Golgi complex. De Graaf, P., Zwart, W.T., Van Dijkern, R.A., Deneka, M., Schulz, T.K., Geijsen, N., Coffer, P.J., Gadella, B.M., Verkleij, A.J., Van Den Sluijs, P. And Van Bergen en Henengouwen, P.M. (2004) Mol. Biol. Cell 15, 2038-2047

Rosas, M., Uings, I.J., van Aalst, C., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (2004) Functional analysis of the interleukin-5 receptor antagonist peptide AF18748, Cytokine 26, 247-254

Remans, P.H., Gringhuis, S.I., van Laar, J.M., Sanders, M.E., Papendrecht-van der Voort, E.A.M, Zwartkruis, F.J.T., Levarht, E.W., Rosas, M., Coffer, P.J., Breedverld, F.C., Bos, J.L., Tak, P.P. and Reedquist, K.A. (2004) Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes. J. Immunol. 173, 920-931

FOXO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase. Bakker, W.J., Blazquez-Domingo, M., Kolbus, A., Besooyen, J., Steinlein, P., Beug, H., Coffer, P.J., Lowenberg, B., von Lindern, M. And van Dijk, T.B. (2004) J. Cell Biol. 164, 175-184

Regulation of granulocyte apoptosis by phosphatidylinositol 3-kinase. Lindemans, C.A. and Coffer, P.J. (2004) Biochem. Soc. Trans. 32, 480-484

Buitenhuis, M., Coffer, P.J. and Koenderman, L. Signal Transducer and Activator of Transcription 5. (2004) Int. J. Biochem. 36, 2120-2124

2003

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. Sunters, A., Fernandez de Mattos, S., Stahl, M., Brosens, J.J., Zoumpoulidou, G., Saunders, C,A,, Coffer, P.J., Medema, R.H., Coombes, R.C. and Lam, E.W. (2003) J. Biol. Chem. 278, 49795-49805

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. Gilley, J., Coffer, P.J. and Ham, J. (2003) J. Cell. Biol. 162, 613-22

Signal Transducer and Activator of Transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood derived CD34 cells. Buitenhuis, M., Baltus, B., Lammers, J-W.J., Coffer, P.J. and Koenderman, L. (2003) Blood 101, 134-142

Rapamycin specifically intereferes with GM-CSF signaling in human dendritic cells leading to apoptosis via increased p27KIP1 expression. Woltman, A.M., van der Kooij, S.W., Coffer, P.J., Offringa, R., Daha, M.R. and van Kooten, C. (2003) Blood 101, 1439-1445

OutFOXing the grim reaper: novel mechanisms regulating longevity by Forkhead transcription factors. Coffer, P.J. (2003) Science (STKE) 2003, pe39

Transcriptional regulation of lymphocyte quiescence: as cunning as a FOX. Coffer, P.J. (2003) Trends Immunol. 24, 470-471

FOXO transcription factors as regulators of immune homeostasis: molecules to die for? Birkenkamp, K.U. and Coffer, P.J. (2003) J. Immunol. 171, 1623-1629

Regulation of cell survival and proliferation by the FOXO family of transcription factors. Bikenkamp, K.U. and Coffer, P.J. (2003) Biochem Soc. Trans. 31, 292-297

2002

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Kops, J.L., Dansen, T.B., Polderman, P.E., Saarloos, I., Wirtz, K.W.A., Coffer, P.J., Huang, T-T., Bos, J.L., Medema, R.H. and Burgering, B.M.T. (2002) Nature 419, 316-320

Role of Ca2 /calmodulin regulated signalling pathways in chemoattractant induced neutrophil effector functions. Verploegen, S., van Leeuwen, C.M., van Deutekom, H.W.M., lammers, J-W.J., Koenderman, L. and Coffer, P.J.  (2002) Eur. J. Biochem. 269, 4625-4634

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: PKB enhanced cell survival through maintenance of mitochondrial integrity. Dijkers, P.F., Birkenkamp, K.U., Lam, E. W-F., Thomas, S.B., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (2002) J. Cell. Biol. 156, 531-542

Control of cell cycle exit and entry by Protein Kinase B-regulated Forkhead transcription factors.  Kops, G.J., Medema, R.H., Glassford, J., Essers, M.A., Dijkers, P.F., Coffer, P.J., Lam, E.W. and Burgering, B.M. (2002) Mol. Cell. Biol. 22, 2025-2036

The Forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. Stahl, M., Dijkers, P.F., Kops, G.J., Lens, S.M., Coffer, P.J., Burgering, B.M. and Medema, R.H. (2002) J. Immunol. 168, 5024-5031

Src-kinases regulate PKB activation and modulate cytokine and chemoattractant controlled neutrophil functioning. Nijhuis, E., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (2002) J. Leuk. Biol. 71, 115-124

2001

Cytokine-specific transcriptional regulation through an IL-5Ra-interacting protein. Geijsen, N., Uings, I., Pals, C., Armstrong, J., Raaijmakers, J.A.M., McKinnon, M., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (2001) Science 293, 1136-1138

Transduction of a dominant-negative H-Ras into human eosinophils attenuates ERK activation and IL-5-mediated cell viability. Hall, D.J., Cui, J., Bates, M.E., Stout, B.A., Koenderman, L., Coffer, P.J. and Bertics, P.J. (2001) Blood 98, 2014-2021

Cytokine-induced inside-out activation of the FcaR (CD89) is mediated by a single serine residue (S263) in the intracellular domain of the receptor. Bracke, M., Lammers, J-W.J., Coffer, P.J. and Koenderman, L. (2001) Blood 97, 3478-3483

Eosinophils: collection, separation and activation. Koenderman, L., van der Linden, J., Ulfman, L. and Coffer, P.J. (2001) Meth. Mol. Med. (ed: Rogers and Donnelly) Vol 56, 217-226

Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family. Geijsen, N., Koenderman, L. and Coffer, P.J. (2001) Cytokine & Growth Factor Reviews 12, 19-25

Molecular regulation of eosinophil activation. Koenderman, L. and Coffer, P.J. (2001) Recent Res. Dev. Allergy & Clin. Immunol. 1, 107-120

Controlling allergic inflammation by signalling regulation of eosinophils. Koenderman, L. and Coffer, P.J. (2001) Allergy  56, 204-214

2000

The forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27KIP1. Dijkers, P.F., Medema, R.H., Pals, C., Banerji, L., Thomas, N.S.B., Lam, E.W., Burgering, B.M.T., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (2000) Mol. Cell. Biol. 20, 9138-9148

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the Forkhead transcription factor FKHR-L1. Dijkers, P.F., Medema, R.H., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (2000) Curr. Biol. 10, 1201-1204

Identification and characterisation of CKLiK: a novel granulocyte Ca2 /calmodulin-dependent kinase. Verploegen, S., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (2000) Blood 96, 3215-3223

In vivo priming of FcaR functioning on eosinophils of allergic asthmatics. Bracke, M., van de Graaf, E., Lammers, J-W.J., Coffer, P.J. and Koenderman, L. (2000) J. Leuk. Biol. 68,655-661

Measurement of signal transduction pathways by phosphospecific antibody cell-based ELISA. Versteeg, H.H., Nijhuis, E., van den Brink, G.R., Evertzen, M., Pynaert, G.N., Deventer, S.J.H., Coffer, P.J. and Peppelenbosch, M.P. (2000) Biochem. J. 350, 717-722

Identification of cytokine-regulated genes in human leukocytes in vivo. Pals, C.E.G.M., Verploegen, S.A.B.W., Raaijmakers, J.A.M., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (2000) J. Allergy Clin. Immunol. 105, 760-8

Cytokine-mediated cPLA2 phosphorylation is regulated by multiple MAPK family members. Geijsen, N., Dijkers, P.F., Lammers, J-W.J., Koenderman,L. and Coffer, P.J. (2000) FEBS Letts. 471, 83-8

A critical role for PI 3-kinase in cytokine-induced Fca-receptor activation. Bracke, M., Nijhuis, E., Lammers, J-W.J., Coffer, P.J. and Koenderman, L. (2000) Blood 95, 2037-2043

Phosphatidylinositol 3-kinase: a tale of two kinase activities. Coffer, P.J. (2000) Protein kinase functions (Ed: J. Woodgett) Oxford University Press, pp 1-40

The role of STATs in myeloid differentiation and leukemia. Coffer, P.J., Koenderman, L. and de Groot, R.P.  (2000) Oncogene 19, 2511-22

Signalling pathways regulating neutrophil effector functions. Verploegen, S., Nijhuis, E., Koenderman, L. and Coffer, P.J. (2000) Molecular mechanisms of signal transduction (Ed: J.H. Bos) IOS Press, pp 261-270

1999

Association of RACK1 and PKCb with the common b-chain of the IL-5/IL-3/GM-CSF receptor. Geijsen, N., Spaargaren M., Raaijmakers, J.A.M., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (1999) Oncogene 18, 5126-5130

Cytokine signal transduction in P19 embryonal carcinoma cells: regulation of Stat3-mediated transactivation occurs independently of p21ras-ERK signalling. van Puijenbroek, A.F.L., vad der Saag, P.T. and Coffer, P.J. (1999) Exp. Cell Res. 251, 465-476

Regulation of p21rac activation in human neutrophils. Geijsen, N., van Delft, S., Raaijmakers, J.A.M., Lammers, J-W.J., Collard, J.G., Koendeman, L. and Coffer, P.J. (1999) Blood 94, 1121-1130

Activation of the small GTPase Ral in neutrophils: Ras- and Rap1-activation fails to activate Ral. M'rabet, L., Coffer, P.J., Zwartkruis, F., Wolthuis, R.M.F., Koenderman, L. and Bos, J.L. (1999) J. Biol. Chem. 274, 21847-21852

Regulation and function of protein kinase B and MAP kinase activation by the IL-5/IL-3/GM-CSF receptor. Dijkers, P.F., van Dijk, T.B., de Groot, R.P., Raaijmakers, J.A.M., Lammers, J-W.J., Koenderman, L. and Coffer, P.J. (1999) Oncogene 18, 3334-3342

1998

Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils. Bracke, M., Coffer, P.J., Lammers, J-W.J. and Koenderman, L. (1998) J. Immunol. 161, 6768-6774

Activation of the small GTPase Rap1 in human neutrophils. M’Rabet, L., Coffer, P.J., Zwartkruis, F., Franke, B., Segal, A.W., Koenderman, L. and Bos, J.L. (1998) Blood 92, 2133-2140

Signal transduction pathways in human eosinophils activated by chemoattractants and the T-helper 2 derived cytokines IL-4 and IL-5. Coffer, P.J., Schweizer, R.C., Dubois, G.R., Maikoe, T., Lammers, J-W. and Koenderman, L. (1998) Blood 91, 2547-2557

Signaling through CD5 activates a pathway involving PI 3-kinase, Vav and Rac1 in human mature T lymphocytes. Gringhuis, S.I., de Leif, L.F.M.H., Coffer, P.J. and Vellenga, E. (1998) Mol. Cell. Biol. 18, 1725-1735

Protein kinase B (c-Akt) regulates glucose transport, glycogen synthesis and protein synthesis by insulin. Ueki K., Yamamoto-Honda, R., Kaburagi, Y., Yamauchi, T., Tobe, K., Burgering, M. Th., Coffer, P.J., Akanuma, Y., Yazaki, Y. and Kadowaki, T. (1998) J. Biol. Chem. 273, 5315-5322

Comparison of the roles of mitogen activated protein kinase kinase and phosphatidylinositol 3-OH kinase signal transduction in neutrophil effector function. Coffer, P.J., Geijsen, N., M’Rabet, L., Schweizer, R.C., Maikoe, T., Bos, J.L., Raaijmakers, J.A.M., Lammers, J-W. and Koenderman, L. (1998) Biochem. J. 329, 121-130

Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family. (1998) de Groot, R.P., Coffer, P.J. and Koenderman, L. Cellular Signalling 10, 619-628

Protein Kinase B (c-akt): a multifunctional mediator of PI-3K activation. Coffer, P.J., Jin, J. and Woodgett, J.R. (1998) Biochem. J. 335, 1-35

1997

Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction. Coffer, P.J., van Puijenbroek, A., Burgering, B.M.Th., Klop-de-Jonge, M., Koenderman, L., Bos, J.L. and Kruijer, W. (1997) Oncogene 15, 2529-2539

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J. and  Evan, G. (1997) Nature 385, 544-8

Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes. Tanti, J.F., Grillo, S., Gremeaux, T., Coffer P.J., Van-Obberghen, E. and Le-Marchand-Brustel, Y, (1997) Endocrinology 138, 2005-10

Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases. de-Groot, R.P., van-Dijk, T.B., Caldenhoven, E., Coffer, P.J., Raaijmakers, J.A., Lammers, J-W. and  Koenderman, L. (1997) J. Biol. Chem. 272, 2319-25

Expression of a constitutively aactivated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Magun, R., Burgering, B.M.Th., Coffer, P.J., Pardasani, D., Lin, Y., Chabot, J. and Sorisky, A. (1997) Endocrinology 137, 3590-3593

Granulocyte signal transduction and priming: cause without effect? Coffer, P.J. and Koenderman, L. (1997) Immunol. Letts. 57, 27-31

1996

Eosinophil priming by cytokines: from cellular signal to in vivo modulation. Koenderman, L., van-der-Bruggen, T., Schweizer, R.C., Warringa, R.A., Coffer P., Caldenhoven, E., Lammers, J-W and  Raaijmakers, J.A. (1996) Eur. Respir. J. 22, 119-125

Protein kinase C-z reverts v-raf transformation of NIH-3T3 cells. Kieser, A., Seitz, T., Adler, H.S., Coffer, P. Kremmer, E., Crespo, P., Gutkind, J.S., Henderson, D.W., Mushinski, J.F., Kolch, W. and Mischak, H. (1996) Genes Dev. 10, 1455-1466

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Burgering, B.M.Th. and Coffer, P.J. (1995) Nature 376, 599-602

UV activation of receptor tyrosine kinase activity. Coffer, P.J., Burgering, B.M.Th.,  Peppelenbosch, M.P., Bos, J.L. and  Kruijer, W. (1995) Oncogene 11, 561-569

EGF receptor deletions define a region specifically mediating STAT transcription factor activation. Coffer, P.J. and  Kruijer, W. (1995) Biochem. Biophys. Res. Commun. 210, 74-81

Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha. van-der-Bruggen, T., Caldenhoven, E., Kanters, D., Coffer, P.J., Raaijmakers, J.A., Lammers, J-W. and  Koenderman, L. (1995) Blood. 85, 1442-8

Transcriptional regulation of the junB promoter: analysis of STAT-mediated signal transduction. Coffer, P., Lutticken, C., van-Puijenbroek, A., Klop-de-Jonge, M., Horn F. and  Kruijer, W. (1995) Oncogene 10, 985-94

Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. Lutticken, C., Coffer, P., Yuan, J., Schwartz, C., Caldenhoven, E., Schindler, C., Kruijer, W., Heinrich, P.C. and Horn, F. (1995) FEBS Letts. 360, 137-143

1995

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Burgering, B.M.Th. and Coffer, P.J. (1995) Nature 376, 599-602

UV activation of receptor tyrosine kinase activity. Coffer, P.J., Burgering, B.M.Th.,  Peppelenbosch, M.P., Bos, J.L. and  Kruijer, W. (1995) Oncogene 11, 561-569

EGF receptor deletions define a region specifically mediating STAT transcription factor activation. Coffer, P.J. and  Kruijer, W. (1995) Biochem. Biophys. Res. Commun. 210, 74-81

Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha. van-der-Bruggen, T., Caldenhoven, E., Kanters, D., Coffer, P.J., Raaijmakers, J.A., Lammers, J-W. and  Koenderman, L. (1995) Blood. 85, 1442-8

Transcriptional regulation of the junB promoter: analysis of STAT-mediated signal transduction. Coffer, P., Lutticken, C., van-Puijenbroek, A., Klop-de-Jonge, M., Horn F. and  Kruijer, W. (1995) Oncogene 10, 985-94

Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. Lutticken, C., Coffer, P., Yuan, J., Schwartz, C., Caldenhoven, E., Schindler, C., Kruijer, W., Heinrich, P.C. and Horn, F. (1995) FEBS Letts. 360, 137-143

1994

Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element. Caldenhoven, E., Coffer, P., Yuan, J., Van-de-Stolpe, A., Horn, F., Kruijer, W. and  Van-der-Saag, P.T. (1994) J. Biol. Chem. 269,  21146-21154

JunB promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2. Coffer, P., de-Jonge, M., Mettouchi, A., Binetruy, B., Ghysdael, J. and Kruijer, W. (1994) Oncogene 9, 911-921

Differential subcellular localisation of two isoforms of p70 S6 protein kinase. Coffer, P.J. and Woodgett, J.R.(1994) Biochem. Biophys. Res. Commun. 198, 780-786

1993

Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells. Nikolakaki, E., Coffer, P.J., Hemelsoet, R., Woodgett, J.R. and  Defize, L.H. (1993) Oncogene 8, 833-840

c-fos induction by stress can be mediated by the SRE. van-Delft, S., Coffer, P., Kruijer, W. and van-Wijk, R. (1993) Biochem. Biophys. Res. Commun. 197, 542-548

1992

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Grove, J.R., Banerjee, P., Balsasubramanyam, A., Coffer, P.J., Price, D.J., Avruch, J. and Woodgett, J.R. (1991) Mol. Cell. Biol. 11, 5541-5550

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Coffer, P.J. and Woodgett, J.R. (1991) Eur. J. Biochem. 205, 475-481