Anita Govers (1983) studied Medicine at the Utrecht University. She started training in pediatrics at the Wilhelmina Children’s Hospital Utrecht in 2008, which she will continue after her PhD. In 2011 she started her PhD in the Cell Growth and Differentiation Lab with Professor P.J. Coffer. Here she studies the biology of pediatric myelodysplastic syndromes (MDS) , as well as the molecular and cellular effects of HDAC inhibitors (HDACi) on human MDS development.
There is increasing evidence of involvement of the microenvironment, the hematopoietic niche, for myeloid leukemias and other bone marrow diseases such as multiple myeloma. However, little is known about the pathophysiology of de novo pediatric MDS. The contribution of the niche in this condition is also unclear. With the use of an in vivo human scaffold model, this project aims to provide more insight in the biology of hematopoietic and mesenchymal stem cells in the development of MDS. Furthermore, with the use of HDACi, it aims to define the role of histone and non-histone acetylation of in hematopoietic and mesenchymal cells in the development of childhood MDS.