Schackmann RCJ, van Amersfoort M, Haarhuis JHI, Vlug EJ , Halim VA , Roodhart JML , Vermaat JS, Voest EE , van der Groep P , van Diest PJ , Jonkers J and Derksen PWB
Cytosolic p120-catenin regulates growth of human and mouse metastatic lobular carcinoma through Rock1-mediated anoikis resistance
J. Clin. Invest. 2011 [in press]
Derksen PW, Braumuller TM, van der Burg E, Hornsveld M, Mesman E, Wesseling J, Krimpenfort P, Jonkers J.
Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice.
Dis Model Mech. 2011 May-Jun;4(3):347-58.
Beerling E, Ritsma L, Vrisekoop N, Derksen PW, van Rheenen J.
Intravital microscopy: new insights into metastasis of tumors.
J Cell Sci. 2011 Feb 1;124(Pt 3):299-310.
Hoogwater FJ, Nijkamp MW, Smakman N, Steller EJ, Emmink BL, Westendorp BF, Raats DA, Sprick MR, Schaefer U, Van Houdt WJ, De Bruijn MT, Schackmann RC, Derksen PW, Medema JP, Walczak H, Borel Rinkes IH, Kranenburg O.
Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.
Gastroenterology. 2010 Jun;138(7):2357-67.
Evers B, Speksnijder EN, Schut E, Ciampricotti M, Smalley MJ, Derksen PW, Jonkers J, de Visser KE.
A tissue reconstitution model to study cancer cell-intrinsic and -extrinsic factors in mammary tumourigenesis.
J Pathol. 2010 Jan;220(1):34-44.
Xian W, Pappas L, Pandya D, Selfors LM, Derksen PW, de Bruin M, Gray NS, Jonkers J, Rosen JM, Brugge JS.
Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival.
Cancer Res. 2009 Mar 15;69(6):2244-51. Epub 2009 Mar 3.
Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AO, Zander SA, Derksen PW, de Bruin M, Zevenhoven J, Lau A, Boulter R, Cranston A, O'Connor MJ, Martin NM, Borst P, Jonkers J
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.
Proc Natl Acad Sci USA. 2008 Nov 4;105(44):17079-84.
Lehembre F, Yilmaz M, Wicki A, Schomber T, Strittmatter K, Ziegler D, Kren A, Went P, Derksen PW, Berns A, Jonkers J, Christofori G.
NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin.
EMBO J. 2008 Oct 8;27(19):2603-15.
Jonkers J, Derksen PW.
Modeling metastatic breast cancer in mice.
J Mammary Gland Biol Neoplasia. 2007;12(2-3):191-203.
Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, Peterse JL, Cardiff RD, Berns A and Jonkers J.
Somatic inactivation of E-cadherin and p53 in mice induces metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.
Cancer Cell. 2006;10(5):437-49.
Tjin EP, Groen RW, Vogelzang I, Derksen PW, Klok MD, Meijer HP, van Eeden S, Pals ST, Spaargaren M.
Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma.
Blood. 2006;107(2):760-8.
Tjin EP, Bende RJ, Derksen PW, van Huijstee AP, Kataoka H, Spaargaren M, Pals ST.
Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator.
J Immunol. 2005;175(5):2807-13.
Tjin EP, Derksen PW, Kataoka H, Spaargaren M, Pals ST.
Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator.
Blood. 2004;104(7):2172-5.
Derksen PW, Tjin E, Meijer HP, Klok MD, Mac Gillavry HD, van Oers MH, Lokhorst HM, Bloem AC, Clevers H, Nusse R, van der Neut R, Spaargaren S, Pals ST.
Illegitimate WNT signaling promotes proliferation of Multiple Myeloma cells.
Proc Natl Acad Sci USA. 2004;101(16):6122-7
Derksen PW, de Gorter DJ, Meijer HP, Bende RJ, van Dijk M, Lokhorst HM, Bloem AC, Spaargaren M, Pals ST.
The hepatocyte growth factor/MET pathway controls proliferation and apoptosis in multiple myeloma.
Leukemia. 2003;17(4):764-74.
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST.
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes MET signaling in multiple myeloma.
Blood. 2002; 15;99(4):1405-10.
van der Voort R, Taher TE, Derksen PW, Spaargaren M, van der Neut R, Pals ST.
The hepatocyte growth factor/MET pathway in development, tumorigenesis and B-cell differentiation.
Adv Cancer Res. 2000;79:39-90.
Derksen PW, Langerak AW, Kerkhof E, Wolvers-Tettero IL, Boor PP, Mulder AH, Vrints LW, Coebergh JW, van Krieken JH, Schuuring E, Kluin PM, van Dongen JJ.
Comparison of different polymerase chain reaction-based approaches for clonality assessment of immunoglobulin heavy-chain gene rearrangements in B-cell neoplasia.
Mod Pathol. 1999;12(8):794-805.
Grant
(2005) NWO-VENI (916.56.135): “Functional characterization of E-cadherin signaling in breast cancer progression and metastasis”.