Research groups

Publications

Selected publications on current research interest

Lens, S.M., Voest, E.E. and Medema, R.H. (2010) Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer 10: 825-841.

Tanenbaum, M.E. and Medema, R.H. (2010) Mechanisms of centrosome separation and bipolar spindle assembly. Dev Cell 19: 797-806.

Splinter, D., Tanenbaum, M.E., Lindqvis,t A., Jaarsma, D., Flotho, A., Yu, K.L., Grigoriev, I., Engelsma, D., Haasdijk, E.D., Keijzer, N., Demmers, J., Fornerod, M., Melchior, F., Hoogenraad, C.C., Medema, R.H., Akhmanova, A. (2010) Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol. 8:e1000350.

Alvarez-Fernández M, Halim VA, Krenning L, Aprelia M, Mohammed S, Heck AJ, Medema RH. (2010) Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1. EMBO Rep. 11:452-458.

Macůrek, L., Lindqvist, A., Voets, O., Kool, J., Vos, H.R., Medema, R.H. (2010) Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition. Oncogene 29:2281-2291.Janssen A, Kops GJ, Medema RH. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19108-13. Epub, Oct 23 (2009) (in process).

Tanenbaum ME, Macůrek L, Janssen A, Geers EF, Alvarez-Fernández M, Medema RH.Kif15 cooperates with eg5 to promote bipolar spindle assembly. Curr Biol. 2009 Nov 3;19(20):1703-11. Epub, Oct 8 (2009) (in process).

Lindqvist A, de Bruijn M, Macurek L, Brás A, Mensinga A, Bruinsma W, Voets O, Kranenburg O, Medema RH. Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. EMBO J. 2009 Oct 21;28(20):3196-206. Epub Aug 27 (2009).

Raaijmakers JA, Tanenbaum ME, Maia AF, Medema RH. RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment.
J Cell Sci. 2009 Jul 15;122(Pt 14):2436-45. Epub Jun 23 (2009).

Tanenbaum ME, Macůrek L, Galjart N, Medema RH. Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly. EMBO J. 2008 Dec 17;27(24):3235-45. Epub Nov 20, (2008).

Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature, 455:119 (2008) .

J. Laoukili J, Álvarez M, Meijer LAT, Stahl M, Mohammed S, Kleij L, Heck AJR, Medema RH. Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain. Mol Cell Biol 28: 3076 (2008).

Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.
Cell 132: 233 (2008).

Mamely I, van Vugt MA, Smits VA, Semple JI, Lemmens B, Perrakis A, Medema RH, Freire R. Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Curr Biol.16: 1950 (2006).

Tanenbaum ME, Galjart N, van Vugt MA, Medema RH. CLIP-170 facilitates the formation of kinetochore-microtubule attachments. EMBO J. 25: 45 (2006).

Schmidt M, Budirahardja Y, Klompmaker R, Medema RH. Ablation of the spindle assembly checkpoint by a compound targeting Mps1. EMBO Rep. 6: 866 (2005).

van de Weerdt BC, van Vugt MA, Lindon C, Kauw JJ, Rozendaal MJ, Klompmaker R, Wolthuis RM, Medema RH. Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1. Mol Cell Biol. 25: 2031 (2005).

Laoukili J, Kooistra MR, Bras A, Kauw J, Kerkhoven RM, Morrison A, Clevers H, Medema RH. FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol. 7: 126 (2005).

van Vugt MA, Bras A, Medema RH. Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol Cell. 15: 799 (2004).

van Vugt MA, van de Weerdt BC, Vader G, Janssen H, Calafat J, Klompmaker R, Wolthuis RM, Medema RH. Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis. J Biol Chem. 279: 36841 (2004).

Schmidt M, Fernandez de Mattos S, van der Horst A, Klompmaker R, Kops GJ, Lam EW, Burgering BM, Medema RH. Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol. 22: 7842 (2002).

van Vugt MA, Smits VA, Klompmaker R, Medema RH. Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion. J Biol Chem. 276: 41656 (2001).

Smits VA, Klompmaker R, Arnaud L, Rijksen G, Nigg EA, Medema RH. Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat Cell Biol. 2: 672 (2000).

> For more publications please check pubmed (Medema R)

Current grants

(2004) NKB-grant: Structure/function analysis of the role of Polo-like kinase-1 in cellular transformation (NKI 2004-3063)
(2004) Vernieuwingsimpuls VICI (ZonMW 918.46.616): Mitotic checkpoints and chromosomal instability in cancer.
(2005) NKB-grant: Structure/function analysis of the role of Polo-like kinase-1 in cellular transformation (UU2004-3063)
(2006) Checkpoint recovery and adaptation following genotoxic therapies (UU2006-3579)
(2007) TI/Pharma kinases in cancer (T3/105)
(2007) CGC member
(2007) NKB-grant: Contribution of FoxM1 to tumorigenesis (UU2007-3826)