Jacqueline (J.) Alblas PhD

senior scientist

Alblas1 Summary of interest and current work
As PI within the research theme Spinal surgery, my research activities are mainly focused on bone tissue engineering. Our aim is to develop hybrid constructs in which scaffold material and cell stimuli are optimally combined with the regenerative potential of adult stem cells. The main focus points are tissue architecture, vascularization, gene delivery and immunological aspects of bone substitutes.
Printing of living cells, which we developed in our lab, has received a lot of attention in the last years, and has expanded considerably. Using this technology, dedicated biomaterials suitable for bioprinting have been developed and optimized and are now ready for further functionalization. They are used to investigate the role of self-organisation of cells and matrix components in tissue repair. This animation shows how bioprinted bone constructs might be applied in the future.

Key side activities

Supervision of PhD students and undergraduate students in bone research
Course director/Teaching Medicine and Biomedical Sciences curriculi (BA/MA), Graduate School of Life Sciences, Regenerative Medicine programme
Board member NBTE (Dutch Society for Biomaterials and Tissue Engineering)
Editorial Board of Bioengineering
Member AO Research Review Commission
WP leader BONE-IP consortium

Education and career history
Assistant professor (2008-present)
Senior post-doc (2005-2008)
Dept. Orthopaedics, Division of Surgical Specialties, UMC Utrecht

Post-doc (1996-2004)
Dept. Molecular Cell Biology an Immunology, VU Medical Center, Amsterdam
Dept. Pulmonology, UMC Utrecht
Dept. Physiological Chemistry, Utrecht University

PhD in Cellular Biochemistry (1996)
'Signal transduction by G protein-coupled receptors’
The Netherlands Cancer Institute, Amsterdam

MSc Biology (1989)
Leiden University

E: j.alblas@umcutrecht.nl
T: +31 88 7550294 (office) or +31 88 7551133 (secr.)

Representative publications
Fedorovich, N. E., Alblas, J., De Wijn, J. R., Hennink, W. E., Verbout, A. B. J., & Dhert, W. J. A. (2007) Hydrogels as extracellular matrices for skeletal tissue engineering: State-of-the-art and novel application in organ printing. Tissue Engineering 13(8), 1905-1925. Cited 99 times

Vermonden, T., Fedorovich, N. E., van Geemen, D., Alblas, J., van Nostrum, C. F., Dhert, W. J. A., & Hennink, W. E. (2008) Photopolymerized thermosensitive hydrogels: Synthesis, degradation, and cytocompatibility. Biomacromolecules, 9(3), 919-926. Cited 47 times

Fedorovich, N. E., De Wijn, J. R., Verbout, A. J., Alblas, J., & Dhert, W. J. A. (2008). Three-dimensional fiber deposition of cell-laden, viable, patterned constructs for bone tissue printing. Tissue Engineering - Part A., 14(1), 127-133. Cited 40 times

Fedorovich, N. E., Oudshoorn, M. H., van Geemen, D., Hennink, W. E., Alblas, J., & Dhert, W. J. A. (2009) The effect of photopolymerization on stem cells embedded in hydrogels. Biomaterials, 30(3), 344-353. Cited 54 times

Gawlitta D, Farrell E, Malda J, Creemers LB, Alblas J, Dhert WJ. Modulating endochondral ossification of multipotent stromal cells for bone regeneration. Tissue Engineering Part B Rev. 2010 Aug;16(4):385-95. Cited 5 times

Fedorovich, N. E., Haverslag, R. T., Dhert, W. J. A., & Alblas, J. (2010) The role of endothelial progenitor cells in prevascularized bone tissue engineering: Development of heterogeneous constructs. Tissue Engineering - Part A 16(7), 2355-2367. Cited 17 times

Geuze RE, Prins HJ, Öner FC, van der Helm YJ, Schuijff LS, Martens AC, Kruyt MC, Alblas J, Dhert WJ. (2010) Luciferase labeling for multipotent stromal cell tracking in spinal fusion versus ectopic bone tissue engineering in mice and rats. Tissue Engineering Part A. 16(11):3343-51. Cited 4 times

Fedorovich, N. E., Alblas, J., Hennink, W. E., Öner, F. C., & Dhert, W. J. A. (2011). Organ printing: The future of bone regeneration? Trends in Biotechnology 29(12), 601-606. Cited 7 times

Wegman, F., Bijenhof, A., Schuijff, L., Oner, F. C., Dhert, W. J., & Alblas, J. (2011). Osteogenic differentiation as a result of BMP-2 plasmid DNA based gene therapy in vitro and in vivo. European Cells & Materials, 21, 230-242; discussion 242. Cited 7 times

Geuze, R. E., Theyse, L. F. H., Kempen, D. H. R., Hazewinkel, H. A. W., Kraak, H. Y. A., Öner, F. C., Dhert, W., Alblas, J. (2012). A differential effect of bone morphogenetic protein-2 and vascular endothelial growth factor release timing on osteogenesis at ectopic and orthotopic sites in a large-animal model. Tissue Engineering - Part A, 18(19-20), 2052-2062. Cited 1 time
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