Jos (J.) Malda PhD

Deputy head of orthopaedic research

Malda2013new3 Current positions
Associate Professor, Department of Orthopaedics, UMC Utrecht (2013-present)
Associate Professor of Joint Regeneration, Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University (2012-present)
Adjunct Associate Professor, Institute of Health and Biomedical Innovation, Queensland University of Technology. Brisbane, Australia (2010-present)

Summary of interest and current work
My research group focuses on biofabrication and biomaterials design, in particular for the regeneration of (osteo) chondral defects (click here). I am developing novel biofabrication strategies, as well and “bioinks” for 3D printing. These hydrogel-based “inks” are both designed to drive specific differentiation of the embedded and/or endogenous cells, as well as to allow fabrication with high shape fidelity in order to generate constructs that are a blueprint of the real tissue. In addition, I am adopting a tissue-derived matrix strategy to biofunctionalise scaffolds for tissue regeneration. Finally, approaches towards the translation of the constructs in veterinary (equine) and human clinics are pursued, including its use as an in vitro platform for testing.

Areas of interest
- Joint regeneration
- Biofabrication
- Biomaterial development
- Extracellular matrix-derived scaffolds
- Nutrient limitation

Key side activities
Course director Utrecht Summer School courses on Regenerative Medicine and on 3D printing and Biofabrication
Co-chair of the Biofabrication 2015 congress in Utrecht, The Netherlands
Board member of the International Cartilage Repair Society (ICRS)
Member of the editorial board of the journal Biofabrication
Member of the editorial board of the journal 3D Printing and Additive Manufacturing
Director of the Utrecht Biofabrication Facility
Work package leader and member of the Steering Committee of the FP7 research project HydroZONES

Education and career history
Associate Professor (2013 - present) Department of Orthopaedics, UMC Utrecht
Associate Professor (2012 - present) Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University
Assistant Professor (2010 - present) Department of Orthopaedics, UMC Utrecht
Post-doc (2007 - 2010) Veni Laureate, Department of Orthopaedics, University Medical Center Utrecht
Post-doc (2004 - 2007) Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
Post-doc (2004) Department of Polymer Chemistry and Biomaterials, University of Twente
PhD in Cartilage Tissue Engineering (2003) 'Cartilage Tissue Engineering: The Role of Oxygen. University of Twente / IsoTis S.A.
MSc Bioprocess Engineering (1994). Wageningen University

Contact
E:
j.malda@umcutrecht.nl

Selected publications

25th anniversary article: Engineering hydrogels for biofabrication.
Malda J, Visser J, Melchels FP, Jüngst T, Hennink WE, Dhert WJ, Groll J, Hutmacher DW. (2013) Advanced Matererials 25(36):5011-5028

Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass.
Malda J, de Grauw JC, Benders KE, Kik MJ, van de Lest CH, Creemers LB, Dhert WJ, van Weeren PR. (2013) PLoS One 8(2):e57683.

Extracellular matrix scaffolds for cartilage and bone regeneration.
Benders KE, Weeren PR, Badylak SF, Saris DB, Dhert WJ, Malda J. (2013) Trends Biotechnology 31(3):169-176

Cartilage regeneration using zonal chondrocyte subpopulations: a promising approach or an overcomplicated strategy?
Schuurman W., Klein T.J., Dhert W.J.A., van Weeren P.R., Hutmacher D.W. and Malda J. (2012) Journal of Tissue Engineering and Regenerative Medicine, in press

Additive manufacturing of tissues and organs
Melchels F.P.W, Domingos M.N.O., Klein T.J., Malda J., Bartolo P. and Hutmacher D.W. (2012)  Progress in Polymer Science, 37(8):1079-1104

Hybrid bioprinting technique to generate organized constructs with improved mechanical properties
Schuurman W., Khristov V., Pot M.W., van Weeren P.R., Dhert W.J.A., and Malda J. (2011)  Biofabrication 3(2):021001

Mathematical modelling of tissue formation in chondrocyte filter cultures
Catt C., Schuurman W., Sengers B., Please C.P.P. Dhert W.J.A. van Weeren P.R. and Malda J. (2011)  European Cells & Materials 22: 377-392

More publications >>>
Disclaimer© 2006-2014 UMC Utrecht, Alle rechten voorbehouden