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Paul J van Diest - Hypoxia
Johan Offerhaus - Gastro intestinal pathology
Peter Nikkels Paediatric Pathology
Niels Bovenschen - Granzyme Biology
Marc Vooijs HIF-Notch Signaling
Roel A de Weger - Heart transplantation
Patrick-Derksen- Breast-Cancer
Roel Goldschmeding - Nephropathology
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Paul J van Diest - Hypoxia
Johan Offerhaus - Gastro intestinal pathology
Peter Nikkels Paediatric Pathology
Niels Bovenschen - Granzyme Biology
Marc Vooijs HIF-Notch Signaling
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Roel A de Weger - Heart transplantation
Patrick-Derksen- Breast-Cancer
Roel Goldschmeding - Nephropathology
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Lees voor
Notch
Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE . Development. 2007 Feb;134(3):535-44.
Pubmed 1
van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature. 2005 Jun 16;435(7044):959-63.
Pubmed 2
Vooijs M, Schroeter EH, Pan Y, Blandford M, Kopan R. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol Chem. 2004 Dec 3;279(49):50864-73. Epub 2004 Sep 23
Pubmed 3
van Tetering G, van Diest P, Verlaan I, van der Wall E, Kopan R, Vooijs M.Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. J Biol Chem. 2009 Nov 6;284(45):31018-27
Pubmed 7
HIF
Gort EH, Groot AJ, van der Wall E, van Diest PJ, Vooijs MA. Hypoxic Regulation of Metastasis via Hypoxia-Inducible Factors. Curr Mol Med. 2008 Feb;8(1):60-7
Pubmed 4
Suijkerbuijk KP, van der Wall E, Vooijs M, van Diest PJ. Molecular analysis of nipple fluid for breast cancer screening. Pathobiology. 2008;75:149-52
Pubmed 5
Gort EH, van Haaften G, Verlaan I, Groot AJ, Plasterk RH, Shvarts A, Suijkerbuijk KP, van Laar T, van der Wall E, Raman V, van Diest PJ, Tijsterman M, Vooijs M The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2alpha. Oncogene. 2008 Mar 6;27(11):1501-10. Epub 2007 Sep 17.
Groot AJ, Mengesha A, van der Wall E, van Diest PJ, Theys J, Vooijs M. Functional antibodies produced by oncolytic clostridia. Biochem Biophys Res Commun. 2007 Dec 28;364(4):985-9. Epub 2007 Oct 29.
Pubmed 6
van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E. COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J Clin Invest. 2010 May 10. pii: 40583. doi: 10.1172/JCI40583. [Epub ahead of print]
Pubmed 8