| Name: |
W.A. (Wilton) van Klei, MD, PhD |
| Function: |
Associate Professor and staff Anesthesiology |
| Department: |
Anesthesiology |
| Division: |
Division of Perioperative and Emergency Care |
| E-mail address: |
W.A.vanKlei@umcutrecht.nl |
| Phone number: |
+31 (0) 88 75 59677 |
| Fax number: |
+31 (0) 30 254 1828 |
| Visiting address: |
UMC Utrecht
Heidelberglaan 100
3584 CX Utrecht
Q04.2.313 |
| Correspondence: |
UMC Utrecht
P.O. Box 85500
3508 GA Utrecht
The Netherlands |
About
Wilton van Klei is involved in clinical research that aims to improve perioperative care. To this aim, he is investigator in several prospective studies, but he is also involved in many retrospective studies that use data obtained from the electronic pre- and intra-operative databases in use at the UMCU.
Examples of past prospective projects are the OPEN study (Outpatient Preoperative Evaluation by Nurses) and the IMPACT trial. The OPEN study was a prospective diagnostic study (N=4,400) performed at the outpatient preoperative evaluation clinic of the UMCU. It quantified the accuracy of trained nurses to correctly assess the pre-operative health status of surgical patients as compared to anesthesiologists. In the subsequent years, the results of this study were implemented in daily clinical practice. The IMPACT trial was a large sized prospective trial (N=12,000) that evaluated the effects on physician behaviour of implementation of a prediction rule to predict postoperative nausea and vomiting in daily practice (choice of anesthetics, administration of prophylaxis).
Most current and future prospective projects again are focusing on further improvement of preoperative evaluation. Examples are an evaluation of the necessity of performing a preoperative ECG, the development of interventions to reduce cognitive decline in octogenerians after non-cardiac surgery and the effects of preoperative physical preconditioning on complications and speed of recovery after gastro-intestinal surgery.
Retrospective database research includes some projects on the effects of intra-operative hypotension on postoperative outcomes (stroke, death), a study that evaluated the effect of increased body mass index on length of stay in the operating room and a project that used the results of an ECG obtained before surgery to predict the occurrence of a postoperative myocardial infarction.