prof. dr. H. T. M. Timmers

Specialisme: Medische Genetica
Divisies: Biomedische Genetica

Contact

E-mail: H.T.M.Timmers@umcutrecht.nl
Telefoon: (+31) 88 756 8981

Biografie

Links:

http://ruummc.med.uu.nl/research/txpn.html

Onderzoek

Key Publications:

• Folkert J. van Werven, Harm van Bakel, Hetty van Teeffelen,Maarten Altelaar, Marian Groot Koerkamp, Albert J.R. Heck, Frank C.P. Holstege, H.Th.Marc Timmers (2008) Cooperativeaction of NC2 and Mot1p to regulate TATA-binding protein function across the genome. Genes Dev. 22, 2359-2369.
• Michiel Vermeulen, Klaas W. Mulder, Sergei Denissov,W.W.M.Pim Pijnappel, Frederik M.A. van Schaik, Radhika A.Warrier, Marijke P.A. Baltissen, Henk G. Stunnenberg, Matthias Mann and H.Th.Marc Timmers (2007) Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine four. Cell 131, 58-69.
• G.Sebastiaan Winkler, Klaas W. Mulder, Vivian J. Bardwell, Eric Kalkhoven and H.Th.Marc Timmers (2006) Human Ccr4-Notcomplex is a ligand-dependent repressor of nuclear receptor-mediated transcription. EMBO J. 25, 3089-3099.
• Koen M.A. Dreijerink, Klaas W. Mulder, G. Sebastiaan Winkler,Jo W.M. Hoppener, Cornelis J.M. Lips and H.Th.Marc Timmers(2006) Menin links estrogen receptor activation to histone H3K4 trimethylation. Cancer Research 66, 4929-4935
• Jan A. van der Knaap, J.W. Borst, Peter C. van der Vliet, R.Gentz and H.Th.Marc Timmers (1997) Cloning of the cDNA for the TATA-binding protein-associated factor (II)170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila. Proc. Natl.Acad. Sci. USA 94, 11827-11832.