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prof. dr. F.W. (Folkert) Asselbergs

Full Professor
prof. dr. F.W. (Folkert) Asselbergs
  • Division of Heart & Lungs

Research Programs

Circulatory Health

Biography

Biography

Prof Dr. Folkert W. Asselbergs is Professor of Precision medicine at Institute of Health Informatics and the institute of Cardiovasculair Science, University College London, Director of the NIHR BRC UCL/UCLH Clinical and Research Informatics Unit, consultant cardiologist and Professor of Precision Medicine at University Medical Center Utrecht, University of Utrecht, the Netherlands, associate editor European Heart Journal, section digital health and innovation, Chair Center for Circulatory Health, UMC Utrecht, and chair data infrastructure Dutch Cardiovascular Alliance (www.dcvalliance.nl). 

 

Professor Asselbergs published more than 400 scientific papers in the field of cardiovascular disease and his work has been funded by the Netherlands Heart Foundation, Netherlands Heart Institute, British Heart Foundation, leDucq Foundation, EU FP7, European Society of Cardiology, BBMRI, National Institutes of Health, Innovative Medicines Initiative, European Research Area Network on Cardiovascular Diseases and ZonMw.

 

His research program in complex genetics focuses on the discovery of genes influencing susceptibility to cardiovascular disease; the application of these findings for the validation of drug targets; and the use of genetic tests for treatment targeting (stratified medicine). Lately, he widened his research focus to precision medicine using linked data sources such as wearable information and routine care data obtained from electronic health records including free text. His ambition is to build a network for performing clinical trials within routine health care linked to national registries. 

 

Prof Asselbergs is member of a large number of consortia and (co-) founded several consortia of which igenetrain (www.igenetrain.net), and GENIUS-CHD (www.genius-chd.org), and CAPACITY-COVID ( https://capacity-covid.eu)  are the most prominent and recent ones. He is scientific coordinator of European IMI Bigdate@heart consortium (www.bigdata-heart.eu). Bigdata@heart aims to deliver clinically relevant disease cardiovascular phenotypes, scalable insights from real-world evidence including data from registries, wearables and electronic health records, and insight driving drug development and personalized medicine through advanced big-data analytics. 

 

Side Activities

  • Prof of Precision medicine at the Institute of Cardiovascular Science and Institute of Director
  • Director Clinical Research Informatics Unit, University College London HospitalHealth Informatics, University College London
  • Medical Scientific Board Member "Deep".
  • Manager Research Center for Circulatory Health, UMC Utrecht

Fellowship and Awards

2014 - Dr. E. Dekker Scholarship of the Netherlands Heart Foundation (2014T001)

2012 - Fellow of the European Society of Cardiology

2010 - Clinical fellowship from the Netherlands Organisation for Health Research and Development(ZonMw grant 90700342)

2003  - Dr. E. Dekker Scholarship of the Netherlands Heart Foundation(NHS 2003T010)

Research Output (375)

Genome-wide analysis identifies novel susceptibility loci for myocardial infarction

Hartiala Jaana A, Han Yi, Jia Qiong, Hilser James R, Huang Pin, Gukasyan Janet, Schwartzman William S, Cai Zhiheng, Biswas Subarna, Trégouët David-Alexandre, Smith Nicholas L, Seldin Marcus, Pan Calvin, Mehrabian Margarete, Lusis Aldons J, Bazeley Peter, Sun Yan V, Liu Chang, Quyyumi Arshed A, Scholz Markus, Thiery Joachim, Delgado Graciela E, Kleber Marcus E, März Winfried, Howe Laurence J, Asselbergs Folkert W, van Vugt Marion, Vlachojannis Georgios J, Patel Riyaz S, Lyytikäinen Leo-Pekka, Kähönen Mika, Lehtimäki Terho, Nieminen Tuomo V M, Kuukasjärvi Pekka, Laurikka Jari O, Chang Xuling, Heng Chew-Kiat, Jiang Rong, Kraus William E, Hauser Elizabeth R, Ferguson Jane F, Reilly Muredach P, Ito Kaoru, Koyama Satoshi, Kamatani Yoichiro, Komuro Issei, Stolze Lindsey K, Romanoski Casey E, Khan Mohammad Daud, Turner Adam W, 1 mrt 2021, In: European heart journal. 42 , p. 919-933 15 p.

P62-positive aggregates are homogenously distributed in the myocardium and associated with the type of mutation in genetic cardiomyopathy

van der Klooster Zoë Joy, Sepehrkhouy Shahrzad, Dooijes Dennis, Te Rijdt Wouter P, Schuiringa Frederique S A M, Lingeman Jolanthe, van Tintelen Johannes Peter, Harakalova Magdalena, Goldschmeding Roel, Suurmeijer Albert J H, Asselbergs Folkert W, Vink Aryan 18 feb 2021, In: Journal of Cellular and Molecular Medicine. 25 , p. 3160-3166 7 p.

Sex Differences in the Risk of Coronary Heart Disease Associated With Type 2 Diabetes:A Mendelian Randomization Analysis

Peters Tricia M, Holmes Michael V, Richards J Brent, Palmer Tom, Forgetta Vincenzo, Lindgren Cecilia M, Asselbergs Folkert W, Nelson Christopher P, Samani Nilesh J, McCarthy Mark I, Mahajan Anubha, Davey Smith George, Woodward Mark, O'Keeffe Linda M, Peters Sanne A E feb 2021, In: Diabetes Care. 44 , p. 556-562 7 p.

Risk Factors and Prevalence of Dilated Cardiomyopathy in Sub-Saharan Africa:Protocol for a Systematic Review

Fundikira Lulu Said, Chillo Pilly, van Laake Linda W, Mutagaywa Reuben Kato, Schmidt Amand Floriaan, Kamuhabwa Appolinary, Kwesigabo Gideon, Asselbergs Folkert W 21 jan 2021, In: JMIR Research Protocols. 10

The new European Heart Journal Digital Health and Innovations Team

Vardas Panos, Asselbergs Folkert, van Smeden Marteen 7 jan 2021, In: European heart journal. 42 , p. 1823-1824 2 p.

Temporal Evolution of Serum Concentrations of High-Sensitivity Cardiac Troponin During 1 Year After Acute Coronary Syndrome Admission

van den Berg Victor J, Oemrawsingh Rohit M, Umans Victor A W M, Kardys Isabella, Asselbergs Folkert W, van der Harst Pim, Hoefer Imo E, Kietselaer Bas, Lenderink Timo, Oude Ophuis Anton J, van Schaik Ron H, de Winter Robbert J, Akkerhuis K Martijn, Boersma Eric, 5 jan 2021, In: Journal of the American Heart Association. 10 , p. 1-13 13 p.

The year in cardiovascular medicine 2020:digital health and innovation

Antoniades Charalambos, Asselbergs Folkert W, Vardas Panos 3 jan 2021, In: European heart journal. 42 , p. 732-739 8 p.

Discovering and Visualizing Disease-specific Electrocardiogram Features Using Deep Learning:Proof-of-concept in Phospholamban Gene Mutation Carriers

van de Leur Rutger, Taha Karim, Bos Max N, van der Heijden Jeroen F, Gupta Deepak, Cramer Maarten J, Hassink Rutger J, van der Harst Pim, Doevendans Pieter A, Asselbergs Folkert W, van Es René 2021, In: Circulation. Arrhythmia and electrophysiology. 14 , p. 138-147

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy

Schuldt Maike, Pei Jiayi, Harakalova Magdalena, Dorsch Larissa M, Schlossarek Saskia, Mokry Michal, Knol Jaco C, Pham Thang V, Schelfhorst Tim, Piersma Sander R, Dos Remedios Cris, Dalinghaus Michiel, Michels Michelle, Asselbergs Folkert W, Moutin Marie-Jo, Carrier Lucie, Jimenez Connie R, van der Velden Jolanda, Kuster Diederik W D 2021, In: Circulation. Heart Failure. 14 , p. 39-55

All research output

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