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prof. dr. F.W. (Folkert) Asselbergs

Full Professor

  • Department of Cardiology

prof. dr. F.W. (Folkert) Asselbergs

Research Programs

Biography

Prof Folkert W. Asselbergs is Prof in cardiovascular genetics and consultant cardiologist at the department of Cardiology, University Medical Center Utrecht, Prof of Precision medicine at the Institute of Cardiovascular Science and Institute of Health Informatics, University College London, Director BRC Clinical Research Informatics Unit, University College London Hospital, Manager Research Center for Circulatory Health, UMC Utrecht, and chair data infrastructure Dutch Cardiovascular Alliance (www.dcvalliane.nl).

 

Professor Asselbergs published more than 300 scientific papers in the field of cardiovascular disease and his work has been funded by the Netherlands Heart Foundation, Netherlands Heart Institute, British Heart Foundation, leDucq Foundation, EU FP7, European Society of Cardiology, BBMRI, National Institutes of Health, Innovative Medicines Initiative, European Research Area Network on Cardiovascular Diseases and ZonMw.

 

His research program in complex genetics focuses on the discovery of genes influencing susceptibility to cardiovascular disease; the application of these findings for the validation of drug targets; and the use of genetic tests for treatment targeting (stratified medicine). Lately, he widened his research focus to precision medicine using linked data sources such as wearable information and routine care data obtained from electronic health records including free text. His ambition is to build a network for performing clinical trials within routine health care linked to national registries. 

 

Prof Asselbergs is member of a large number of consortia and (co-) founded several consortia of which igenetrain (www.igenetrain.net), and GENIUS-CHD (www.genius-chd.org) are the most prominent ones. He is scientific coordinator of European IMI Bigdata@Heart consortium (www.bigdata-heart.eu). BigData@Heart aims to deliver clinically relevant disease cardiovascular phenotypes, scalable insights from real-world evidence including data from registries, wearables and electronic health records, and insights driving drug development and personalized medicine through advanced big-data analytics. 

 

 

 

 

Side Activities

    • Prof of Precision medicine at the Institute of Cardiovascular Science and Institute of Director
    • Director Clinical Research Informatics Unit, University College London HospitalHealth Informatics, University College London
    • Medical Scientific Board Member "Deep".
    • Manager Research Center for Circulatory Health, UMC Utrecht

Fellowship and Awards

  • 2014 - Dr. E. Dekker Scholarship of the Netherlands Heart Foundation (2014T001)

    2012 - Fellow of the European Society of Cardiology

    2010 - Clinical fellowship from the Netherlands Organisation for Health Research and Development(ZonMw grant 90700342)

    2003  - Dr. E. Dekker Scholarship of the Netherlands Heart Foundation(NHS 2003T010)

Research Output (314)

Strength of patient cohorts and biobanks for cardiomyopathy research

de Boer R A, Nijenkamp L L A M, Silljé H H W, Eijgenraam T R, Parbhudayal R, van Driel B, Huurman R, Michels M, Pei J, Harakalova M, van Lint F H M, Jansen M, Baas A F, Asselbergs F W, van Tintelen J P, Brundel B J J M, Dorsch L M, Schuldt M, Kuster D W D, van der Velden J, aug 2020, In: Netherlands Heart Journal. 28 , p. 50-56 7 p.

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Pei Jiayi, Harakalova Magdalena, Treibel Thomas A, Lumbers R Thomas, Boukens Bastiaan J, Efimov Igor R, van Dinter Jip T, González Arantxa, López Begoña, El Azzouzi Hamid, van den Dungen Noortje, van Dijk Christian G M, Krebber Merle M, den Ruijter Hester M, Pasterkamp Gerard, Duncker Dirk J, Nieuwenhuis Edward E S, de Weger Roel, Huibers Manon M, Vink Aryan, Moore Jason H, Moon James C, Verhaar Marianne C, Kararigas Georgios, Mokry Michal, Asselbergs Folkert W, Cheng Caroline 14 jul 2020, In: Clinical Epigenetics. 12 18 p.

A mutation update for the FLNC gene in myopathies and cardiomyopathies

Verdonschot Job A J, Vanhoutte Els K, Claes Godelieve R F, Helderman-van den Enden Apollonia T J M, Hoeijmakers Janneke G J, Hellebrekers Debby M E I, de Haan Amber, Christiaans Imke, Lekanne Deprez Ronald H, Boen Hanne M, van Craenenbroeck Emeline M, Loeys Bart L, Hoedemaekers Yvonne M, Marcelis Carlo, Kempers Marlies, Brusse Esther, van Waning Jaap I, Baas Annette F, Dooijes Dennis, Asselbergs Folkert W, Barge-Schaapveld Daniela Q C M, Koopman Pieter, van den Wijngaard Arthur, Heymans Stephane R B, Krapels Ingrid P C, Brunner Han G jun 2020, In: Human mutation. 41 , p. 1091-1111 21 p.

The relation between healthy lifestyle changes and decrease in systemic inflammation in patients with stable cardiovascular disease

van ’t Klooster C. C., van der Graaf Y., Ridker P. M., Westerink J., Hjortnaes J., Sluijs I., Asselbergs F. W., Bots M. L., Kappelle L. J., Visseren F. L.J., mei 2020, In: Atherosclerosis. 301 , p. 37-43 7 p.

High-frequency metabolite profiling and the incidence of recurrent cardiac events in patients with post-acute coronary syndrome

Vroegindewey Maxime M., van den Berg Victor J., Oemrawsingh Rohit M., Kardys Isabella, Asselbergs Folkert W., van der Harst Pim, Kietselaer Bas, Lenderink Timo, Akkerhuis K. Martijn, Boersma Eric 2 apr 2020, In: Biomarkers. 25 , p. 235-240

Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients

Crnko Sandra, Printezi Markella I, Jansen Tijn P J, Leiteris Laurynas, van der Meer Manon G, Schutte Hilde, van Faassen Martijn, du Pré Bastiaan C, de Jonge Nicolaas, Asselbergs Folkert W, Gaillard Carlo A J M, Kemperman Hans, Doevendans Pieter A, Sluijter Joost P G, van Laake Linda W 31 mrt 2020, In: ESC heart failure. 7 , p. 1224-1233 10 p.

Cardiovascular adverse events in patients with non-Hodgkin lymphoma treated with first-line cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP with rituximab (R-CHOP):a systematic review and meta-analysis

Linschoten Marijke, Kamphuis Janine A M, van Rhenen Anna, Bosman Laurens P, Cramer Maarten J, Doevendans Pieter A, Teske Arco J, Asselbergs Folkert W 2 mrt 2020, In: Lancet haematology. 7 , p. e295-e308 14 p.

Outcome of mechanical circulatory support at the University Medical Centre Utrecht

Felix S E A, Ramjankhan F Z, Buijsrogge M P, Jacob K A, Asselbergs F W, Oerlemans M I F, Kirkels J H, van Laake L W, Oppelaar A M C, Suyker W J L, de Jonge N 24 feb 2020, In: Netherlands Heart Journal. 28 , p. 210-218 9 p.

Quantitative Approach to Fragmented QRS in Arrhythmogenic Cardiomyopathy:From Disease towards Asymptomatic Carriers of Pathogenic Variants

Roudijk Rob W, Bosman Laurens P, van der Heijden Jeroen F, de Bakker Jacques M T, Hauer Richard N W, van Tintelen J Peter, Asselbergs Folkert W, Te Riele Anneline S J M, Loh KP 17 feb 2020, In: Journal of Clinical medicine. 9 12 p.

Progression of conventional cardiovascular risk factors and vascular disease risk in individuals:insights from the PROG-IMT consortium

Bahls Martin, Lorenz Matthias W., Dörr Marcus, Gao Lu, Kitagawa Kazuo, Tuomainen Tomi Pekka, Agewall Stefan, Berenson Gerald, Catapano Alberico L., Norata Giuseppe D., Bots Michiel L., van Gilst Wiek, Asselbergs Folkert W., Brouwers Frank P., Uthoff Heiko, Sander Dirk, Poppert Holger, Hecht Olsen Michael, Empana Jean Philippe, Schminke Ulf, Baldassarre Damiano, Veglia Fabrizio, Franco Oscar H., Kavousi Maryam, de Groot Eric, Mathiesen Ellisiv B., Grigore Liliana, Polak Joseph F., Rundek Tatjana, Stehouwer Coen D.A., Skilton Michael R., Hatzitolios Apostolos I., Savopoulos Christos, Ntaios George, Plichart Matthieu, McLachlan Stela, Lind Lars, Willeit Peter, Steinmetz Helmuth, Desvarieux Moise, Ikram M. Arfan, Johnsen Stein Harald, Schmidt Caroline, Willeit Johann, Ducimetiere Pierre, Price Jackie F., Bergström Göran, Kauhanen Jussi, Kiechl Stefan, Sitzer Matthias, 1 feb 2020, In: European Journal of Preventive Cardiology. 27 , p. 234-243 10 p.

All Research Output (314)