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prof. dr. F.W. (Folkert) Asselbergs

prof. dr. F.W. (Folkert) Asselbergs

Full Professor
prof. dr. F.W. (Folkert) Asselbergs
  • Division of Heart & Lungs

Biography

Biography

Prof Dr. Folkert W. Asselbergs is Professor of Precision medicine at Institute of Health Informatics and the institute of Cardiovasculair Science, University College London, Director of the NIHR BRC UCL/UCLH Clinical and Research Informatics Unit, consultant cardiologist and Professor of Precision Medicine at University Medical Center Utrecht, University of Utrecht, the Netherlands, associate editor European Heart Journal, section digital health and innovation, Chair Center for Circulatory Health, UMC Utrecht, and chair data infrastructure Dutch Cardiovascular Alliance (www.dcvalliance.nl). 

 

Professor Asselbergs published more than 500 scientific papers in the field of cardiovascular disease and his work has been funded by the Netherlands Heart Foundation, Netherlands Heart Institute, British Heart Foundation, leDucq Foundation, EU FP7, European Society of Cardiology, BBMRI, National Institutes of Health, Innovative Medicines Initiative, European Research Area Network on Cardiovascular Diseases and ZonMw.

 

His research program in complex genetics focuses on the discovery of genes influencing susceptibility to cardiovascular disease; the application of these findings for the validation of drug targets; and the use of genetic tests for treatment targeting (stratified medicine). Lately, he widened his research focus to precision medicine using linked data sources such as wearable information and routine care data obtained from electronic health records including free text. His ambition is to build a network for performing clinical trials within routine health care linked to national registries. 

 

Prof Asselbergs is member of a large number of consortia and (co-) founded several consortia of which igenetrain (www.igenetrain.net), and GENIUS-CHD (www.genius-chd.org), and CAPACITY-COVID ( https://capacity-covid.eu)  are the most prominent and recent ones. He is scientific coordinator of European IMI Bigdate@heart consortium (www.bigdata-heart.eu). Bigdata@heart aims to deliver clinically relevant disease cardiovascular phenotypes, scalable insights from real-world evidence including data from registries, wearables and electronic health records, and insight driving drug development and personalized medicine through advanced big-data analytics. 

 

Side Activities

  • Prof of Precision medicine at the Institute of Cardiovascular Science and Institute of Health Informatics, University College London
  • Director NIHR BRC Clinical Research Informatics Unit, University College London Hospital
  • Chair Center for Circulatory Health, UMC Utrecht
  • Chair data infrastructure Dutch Cardiovascular Alliance (www.dcvalliane.nl)
  • Associate editor European Heart Journal, section Digital Health and Innovation

Fellowship and Awards

2003 Dr. E. Dekker Scholarship of the Dutch Heart Foundation (2003T010).
2005 Scholarship Netherlands Heart Institute for postdoc Harvard School of public health
2007 Netherlands Foundation of CardioVascular Excellence grant
2010 Clinical fellowship from the Netherlands Organisation for Health Research (ZonMw grant 90700342),
2012 European Society of Cardiology Training grant (T2012-006).
2013 Fellow European Society of Cardiology
2014 Dr. E. Dekker Scholarship of the Dutch Heart Foundation (2014T001)
2019 Scholarship European Society of Cardiology Executive Master Health Economics at LSE
2021 Pearl award ZonMw, Netherlands: www.zonmw.nl/nl/actueel/parelprojecten/parel-voorbruggenbouwer-in-hartfalen-onderzoek/

Research Output (525)

Author Correction:The power of genetic diversity in genome-wide association studies of lipids (Nature, (2021), 600, 7890, (675-679), 10.1038/s41586-021-04064-3)

Graham Sarah E, Clarke Shoa L, Wu Kuan-Han H, Kanoni Stavroula, Zajac Greg J M, Ramdas Shweta, Surakka Ida, Ntalla Ioanna, Vedantam Sailaja, Winkler Thomas W, Locke Adam E, Marouli Eirini, Hwang Mi Yeong, Han Sohee, Narita Akira, Choudhury Ananyo, Bentley Amy R, Ekoru Kenneth, Verma Anurag, Trivedi Bhavi, Martin Hilary C, Hunt Karen A, Hui Qin, Klarin Derek, Zhu Xiang, Thorleifsson Gudmar, Helgadottir Anna, Gudbjartsson Daniel F, Holm Hilma, Olafsson Isleifur, Akiyama Masato, Sakaue Saori, Terao Chikashi, Kanai Masahiro, Zhou Wei, Brumpton Ben M, Rasheed Humaira, Ruotsalainen Sanni E, Havulinna Aki S, van der Laan Sander W, van Setten Jessica, de Kleijn Dominique, de Borst Gert J, Asselbergs Folkert W, Kraaijeveld Adriaan O, Beulens Joline W J, Pasterkamp Gerard, Hoefer Imo E, van der Harst Pim, Holmes Michael V, 26 May 2023, In: Nature. 618 , p. E19-E20

Druggable proteins influencing cardiac structure and function:Implications for heart failure therapies and cancer cardiotoxicity

Schmidt Amand F, Bourfiss Mimount, Alasiri Abdulrahman, Puyol-Anton Esther, Chopade Sandesh, van Vugt Marion, van der Laan Sander W, Gross Christian, Clarkson Chris, Henry Albert, Lumbers Tom R, van der Harst Pim, Franceschini Nora, Bis Joshua C, Velthuis Birgitta K, Te Riele Anneline S J M, Hingorani Aroon D, Ruijsink Bram, Asselbergs Folkert W, van Setten Jessica, Finan Chris 28 Apr 2023, In: Science advances. 9 17 p.

Incidence and risk factors of late right heart failure in chronic mechanical circulatory support

Felix Susanne E A, Numan Lieke, Oerlemans Marish I F, Aarts E, Ramjankhan Faiz Z, Gianoli Monica, Asselbergs Folkert W, de Jonge Nicolaas, van Laake Linda W 9 Apr 2023, In: Artificial Organs. 47 , p. 1192-1201 10 p.

Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T-cells

Engelen Suzanne E, Ververs Francesca A, Markovska Angela, Lagerholm B Christoffer, Kraaijenhof Jordan M, Yousif Laura Ie, Zurke Yasemin-Xiomara, Gulersonmez Can Mc, Kooijman Sander, Goddard Michael, van Eijkeren Robert J, Jervis Peter J, Besra Gurdyal S, Haitjema Saskia, Asselbergs Folkert W, Kalkhoven Eric, Ploegh Hidde L, Boes Marianne, Cerundolo Vincenzo, Hovingh G Kees, Salio Mariolina, Stigter Edwin Ca, Rensen Patrick Cn, Monaco Claudia, Schipper Henk S 28 Mar 2023, In: JCI Insight. 8

Untargeted Metabolomics Identifies Potential Hypertrophic Cardiomyopathy Biomarkers in Carriers of MYBPC3 Founder Variants

Jansen Mark, Schuldt Maike, van Driel Beau O, Schmidt Amand F, Christiaans Imke, van der Crabben Saskia N, Hoedemaekers Yvonne M, Dooijes Dennis, Jongbloed Jan D H, Boven Ludolf G, Deprez Ronald H Lekanne, Wilde Arthur A M, Jans Judith J M, van der Velden Jolanda, de Boer Rudolf A, van Tintelen J Peter, Asselbergs Folkert W, Baas Annette F 17 Feb 2023, In: International journal of molecular sciences. 24

Optimizing cardiovascular risk assessment and registration in a developing cardiovascular learning health care system:Women benefit most

Groenhof T Katrien J, Haitjema Saskia, Lely A Titia, Grobbee Diederick E, Asselbergs Folkert W, Bots Michiel L, 8 Feb 2023, In: PLOS digital health. 2

Long COVID and the cardiovascular system - elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies:a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases

Gyöngyösi Mariann, Alcaide Pilar, Asselbergs Folkert W., Brundel Bianca J.J.M., Camici Giovanni G., Da Costa Martins Paula, Ferdinandy Péter, Fontana Marianna, Girao Henrique, Gnecchi Massimiliano, Gollmann-Tepeköylü Can, Kleinbongard Petra, Krieg Thomas, Madonna Rosalinda, Paillard Melanie, Pantazis Antonis, Perrino Cinzia, Pesce Maurizio, Schiattarella Gabriele G., Sluijter Joost P.G., Steffens Sabine, Tschöpe Carsten, Van Linthout Sophie, Davidson Sean M. 1 Feb 2023, In: Cardiovascular research. 119 , p. 336-356 21 p.

Patterns in the Use of Heart Failure Telemonitoring:Post Hoc Analysis of the e-Vita Heart Failure Trial

Brons Maaike, Klooster Iris ten, Gemert-Pijnen Lisette van, Jaarsma Tiny, Asselbergs Folkert W., Oerlemans Marish I.F.J., Koudstaal Stefan, Rutten Frans H. 31 Jan 2023, In: JMIR Cardio. 7

Prognostic value of strain by feature-tracking cardiac magnetic resonance in arrhythmogenic right ventricular cardiomyopathy

Bourfiss M., Prakken N. H.J., James C. A., Planken R. N., Boekholdt S. M., Ahmetagic D., van den Berg M. P., Tichnell C., Van der Heijden J. F., Loh P., Murray B., Tandri H., Kamel I., Calkins H., Asselbergs F. W., Zimmerman S. L., Velthuis B. K., Te Riele A. S.J.M. Jan 2023, In: European Heart Journal Cardiovascular Imaging. 24 , p. 98-107 10 p.

Deep neural network-based clustering of deformation curves reveals novel disease features in PLN pathogenic variant carriers

Taha Karim, van de Leur Rutger R., Vessies Melle, Mast Thomas P., Cramer Maarten J., Cauwenberghs Nicholas, Verstraelen Tom E., de Brouwer Remco, Doevendans Pieter A., Wilde Arthur, Asselbergs Folkert W., van den Berg Maarten P., D’hooge Jan, Kuznetsova Tatiana, Teske Arco J., van Es René 2023, In: International Journal of Cardiovascular Imaging. 39 , p. 2149-2161 13 p.

All research output

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