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prof. dr. J.M. Beekman

prof. dr. J.M. Beekman

Full Professor
prof. dr. J.M. Beekman
  • Pulmonology Research 2
  • Onderzoek

Biography

Biography

Dr. J.M. Beekman obtained a PhD in molecular immunology in 2004, and performed multiple post docs in molecular and cell biology within various immunological settings. In October 2010, he became principle investigator at the UMC Utrecht, and started a novel translational research line focusing on developing novel therapeutic strategies for cystic fibrosis, a genetic disease characterized by aberrant ion and fluid homeostasis at mucosal surfaces leading to chronic infection and inflammation and early death around the 3rd to 4th decade of life.

 

‘People with chronic diseases living healthy lives: I strive to create breakthrough solutions for clinical needs of people with chronic diseases by scientific research that focuses on the development of novel diagnostic or therapeutic approaches. This requires a multidisciplinary approach in which basic and clinical research is aligned, and integrated with needs of patients, the private sector and regulatory authorities. Currently, I am particularly proud of leading a team that developed a highly innovative diagnostic assay that enables individualized therapy for people with cystic fibrosis that lead to direct clinical impact for people within 4 years after the initial discovery.’

Side Activities

Professional activities

2021    Co-founder Fair Therapeutics 

2020    Member selection committee for “3V-stimuleringsfonds” UU and UMCU     

2019    Vice-president organizing committee European CF society conference 2022  

2018    PhD Committee and opponent of Franz Shan Brunel, University of Aberdeen, UK 

2017    PhD Committee and opponent of Karen Schelde, University of Aarhus, Denmark 

2017    Consultant at CFF Theratyping workshop  

2016    European CF society basic science working group – vice coordinator 

2016    Grant reviewer Canadian Foundation for Innovation 

2016    Grant reviewer Cystic Fibrosis Research, Inc. (CFRI) 

2016    Grant reviewer German CF society 

2016    Advisor for future funding of UK Cystic Fibrosis Trust (Research Sandpit Workshop, 8-9 Feb) 

2015     Grant reviewer SRC grant application Cystic Fibrosis Trust (UK) 

2015     Avicenna Roadmap Authoring Team – A strategy for in silico clinical trials 

2013 –  Editorial board member of Rare Diseases

2013 –  Editorial board member of PlosOne

2013 –  Annual candidate selection committee for Eureka Institute of Translational Medicine

2010 –   Reviewer for various journals including Cell, Nature Medicine, Nature Communications, PlosOne, Journal of Immunological Methods, Journal of Leukocyte Biology, Molecular Immunology, Journal of Medical Genetics, Journal of Cystic Fibrosis

Memberships

2019-     UWE, collaboration Utrecht-Wageningen-Eindhoven

2019-     Membership transition-team for animal-free innovation Utrecht

2014 –    European Respiratory Society

2010 –    European Cystic Fibrosis Society

2011 –    Eureka Institute for Translational Medicine

2000 –    Dutch Society of Immunology (NVVI

 

Potential Conflicts of Interest

Dr Beekman has regular interactions with commercial parties including pharmaceutical companies, and performs academic associated research mostly in public-private partnerships or fee-for-service activities with such companies. Beekman was PI on grants with Galapagos, Proteostasis, and Eloxx Pharmaceuticals that led to major funding contributions from these companies to UMCU (>100K). Other companies provided in kind contributions. He is inventor of a patent (20210333266) that was licensed to Hubrecht Organoid Technology and he received personal royalties from 2017 onward (max annual income <3000 euros up to 2021) from the Royal Dutch Academy of Sciences and Arts. Dr Beekman has received personal support for preparation of meetings or consultancy (all below 2200 euro per event), or reimbursement of traveling and lodging costs for participating in industry-sponsored educational meeting (all below €2200 per event). He co-founded FAIR therapeutics BV in 2021 and has a minority shareholders position.

Research Output (108)

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

Amatngalim Gimano D, Rodenburg Lisa W, Aalbers Bente L, Raeven Henriette Hm, Aarts Ellen M, Sarhane Dounia, Spelier Sacha, Lefferts Juliet W, Silva Iris Al, Nijenhuis Wilco, Vrendenbarg Sacha, Kruisselbrink Evelien, Brunsveld Jesse E, van Drunen Cornelis M, Michel Sabine, de Winter-de Groot Karin M, Heijerman Harry G, Kapitein Lukas C, Amaral Magarida D, van der Ent Cornelis K, Beekman Jeffrey M Dec 2022, In: Life Science Alliance. 5 , p. 1-14

Drug Repurposing for Cystic Fibrosis:Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids

Rodenburg Lisa W., Delpiano Livia, Railean Violeta, Centeio Raquel, Pinto Madalena C., Smits Shannon M.A., van der Windt Isabelle S., van Hugten Casper F.J., van Beuningen Sam F.B., Rodenburg Remco N.P., van der Ent Cornelis K., Amaral Margarida D., Kunzelmann Karl, Gray Michael A., Beekman Jeffrey M., Amatngalim Gimano D. 21 Oct 2022, In: International Journal of Molecular Sciences. 23

Recurrent respiratory syncytial virus infection in a CD14 deficient patient

Besteman Sjanna B, Phung Emily, Raeven Henriette H M, Amatngalim Gimano D, Rumpret Matevž, Crabtree Juliet, Schepp Rutger M, Rodenburg Lisa W, Siemonsma Susanna G, Verleur Nile, van Slooten Rianne, Duran Karen, van Haaften Gijs, Beekman Jeffrey M, Chang Lauren A, Meyaard Linde, van der Bruggen Tjomme, Berbers Guy A M, Derksen Nicole, Nierkens Stefan, Morabito Kaitlyn M, Ruckwardt Tracy J, Kurt-Jones Evelyn A, Golenbock Douglas, Graham Barney S, Bont Louis J 16 Apr 2022, In: The Journal of infectious diseases. 226 , p. 258-269 12 p.

Mutation-specific reporter for optimization and enrichment of prime editing

Schene I F, Joore I P, Baijens J H L, Stevelink R, Kok G, Shehata S, Ilcken E F, Nieuwenhuis E E S, Bolhuis D P, van Rees R C M, Spelier S A, van der Doef H P J, Beekman J M, Houwen R H J, Nieuwenhuis E E S, Fuchs S A 1 Mar 2022, In: Nature Communications. 13

Forskolin induced swelling (FIS) assay in intestinal organoids to guide eligibility for compassionate use treatment in a CF patient with a rare genotype

Aalbers B L, Brunsveld J E, van der Ent C K, van den Eijnden J C, Beekman J M, Heijerman H G M 30 Jan 2022, In: Journal of Cystic Fibrosis. 21 , p. 254-257 4 p.

Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression

Muilwijk Danya, de Poel Eyleen, van Mourik Peter, Suen Sylvia W F, Vonk Annelotte M, Brunsveld Jesse E, Kruisselbrink Evelien, Oppelaar Hugo, Hagemeijer Marne C, Berkers Gitte, de Winter-de Groot Karin M, Heida-Michel Sabine, Jans Stephan R, van Panhuis Hannah, van der Eerden Menno M, van der Meer Renske, Roukema Jolt, Dompeling Edward, Weersink Els J M, Koppelman Gerard H, Vries Robert, Zomer-van Ommen Domenique D, Eijkemans Marinus J C, van der Ent Cornelis K, Beekman Jeffrey M 27 Jan 2022, In: The European respiratory journal. 60 , p. 1-11

In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center

Rümke Lidewij W, Groenveld Femke C, van Os Yvonne M G, Praest Patrique, Tanja Anniek A N, de Jong Dorien T C M, Symons Jori, Schuurman Rob, Reinders Tessa, Hofstra L Marije, Nierkens Stefan, Thijsen Steven F T, Heron Michiel, Lebbink Robert-Jan, Beekman Jeffrey M, Nijhuis Monique, Wensing Annemarie M J Jan 2022, In: Open forum infectious diseases. 9 , p. 1-6

Prediction of Real-World Long-Term Outcomes of People with CF Homozygous for the F508del Mutation Treated with CFTR Modulators

Muilwijk Danya, Bierlaagh Marlou, van Mourik Peter, Kraaijkamp Jasmijn, van der Meer Renske, van den Bor Rutger, Heijerman Harry, Eijkemans René, Beekman Jeffrey, van der Ent Kors 16 Dec 2021, In: Journal of Personalized Medicine. 11 , p. 1-12

Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

Geurts Maarten H., de Poel Eyleen, Pleguezuelos-Manzano Cayetano, Oka Rurika, Carrillo Léo, Andersson-Rolf Amanda, Boretto Matteo, Brunsveld Jesse E., van Boxtel Ruben, Beekman Jeffrey M., Clevers Hans Oct 2021, In: Life Science Alliance. 4

Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids

de Poel E., Spelier S., Suen S. W.F., Kruisselbrink E., Graeber S. Y., Mall M. A., Weersink E. J.M., van der Eerden M. M., Koppelman G. H., van der Ent C. K., Beekman J. M. Oct 2021, In: Journal of Cystic Fibrosis. 21 , p. 246-253 8 p.

All research output

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