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dr. J. (Jaap-Jan) Boelens

Associate Professor - medical

  • SCT patient care

dr. J. (Jaap-Jan) Boelens

Biography

Jaap-Jan Boelens is a pediatrician – oncologist/Immunologist. He received his PhD at the University of Amsterdam/Academic Medical Center in 1999. He was trained as a paediatrician in the Leiden UMC and the Juliana Children’s Hospital in Den Haag followed by completion of clinical fellowship in immunology (2006, UMC Utrecht) and oncology (2011, ErasmusMC, Rotterdam). His clinical sub-specialization is Hemapoietic Cell Transplantation (HCT) and he is working as a consultant in HCT at the UMC Utrecht since 2006.

He has a special interest in rare-diseases (as indication for HCT) in particular “lysosomal storage diseases” and finding strategies to get better disease control (in malignant diseases). His research group (Group Boelens / Nierkens: U-DANCE) focuses on the development of cord blood derived dendritic cell vaccines (anti-AML, anti-Neuroblastoma). In addition there is a special interest designing a predictable low toxic conditioning regimen using PK/PD-models for e.g. ATG (anti-thymocyte globuline) to better predict the immune-reconstitution (nessasary for optimal effect vaccines). In his group are 4 PostDocs, 5 PhD students and 3 technicians working. He is a frequently invited speaker on international conferences and has over 130 peer-reviewed publications. He is (co-)PI on various phase I/II trials with ATMPs. He is VP elect of the ISCT EU (2016-2018) and will the VP of ISCT EU from 2018-2020 and is also director of the CBA (Cord Blood Association) board (till 2020).

Side Activities

  • Co-Chair Working Committee Benign Disorders (PID, bone marrow failure syndromes, hemoglobinopathies and metabolic diseases) CIBMTR.

    Pediatric Organizing Committee (2013-2016): BMT Tandem Meetings (ASBMT/CIBMTR)

    Board of a recently formed “Westhafen Intercontinental group” aiming to integrate/homogenize the EU and USA transplant and cell therapy practices and trying to come beyond phase I/II studies involving ATMPs (advanced therapy medicinal products).

    Advisory Board / Consultancy GSK: Genetherapy in Metabolic diseases

    Advisory Board Genetherapy Trial (Telethon): X-CGD (X-Linked Chronic Granulomatous Disease)

    Associate Editor Cytotherapy (Journal of ISCT: International Society of Cell Therapy)

    Advisory Board / Consultancy Novartis: Cell- and Genetherapy

    PSIG Organizing Committee (Tandem meetings) 2014 - 2016

Fellowship and Awards

  • ZonMW TAS (as PI): Development of a cord blood stem cell-derived anti-AML dendritic cell vaccine: Towards powerful "anti-AML immunity" after cord blood transplantation (2014 -2018): 1.7M Euro

    ZonMW Priority Medicine Children: Towards Individualized ATG dosing (2012-2016): 0.5M Euro

    Various KIKA grants: Cumm. 2M, Villa Joep/Stichting AMMODO: 0.5M, various smaller grants (including Harmanus Ehrhart)

    Current active funding: 4.5M

    2015: Swammerdam Prijs (van Ned.Vereniging voor Hematologie)

    " Elisabeth von Freyburg prijs 2013" voor baanbrekend onderzoek binnen Kinderoncologie

     

Research Output (254)

Hurdles in treating Hurler disease:potential routes to achieve a "real" cure

van den Broek Brigitte T A, van Doorn Jaap, Hegeman Charlotte V, Nierkens Stefan, Lindemans Caroline A, Verhoeven-Duif Nanda, Boelens Jaap Jan, van Hasselt Peter M 23 jun 2020, In: Blood Advances. 4 , p. 2837-2849 13 p.

A semi-mechanistic model based on glutathione depletion to describe intra-individual reduction in busulfan clearance

Langenhorst J B, Boss J, van Kesteren C, Lalmohamed A, Kuball J, Egberts A C G, Boelens J J, Huitema A D R, van Maarseveen E M 18 feb 2020, In: British Journal of Clinical Pharmacology. 86 , p. 1499-1509 11 p.

Metachromatic leukodystrophy and transplantation:remyelination, no cross-correction

Wolf Nicole I., Breur Marjolein, Plug Bonnie, Beerepoot Shanice, Westerveld Aimee S.R., van Rappard Diane F., de Vries Sharon I., Kole Maarten H.P., Vanderver Adeline, van der Knaap Marjo S., Lindemans Caroline A., van Hasselt Peter M., Boelens Jaap J., Matzner Ulrich, Gieselmann Volkmar, Bugiani Marianna 22 jan 2020, In: Annals of Clinical and Translational Neurology. 7 , p. 169-180 12 p.

Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile

van der Wagen Lotte E, Miranda-Bedate Alberto, Janssen Anke, Fernando Febilla, Appukudige Nagesha, van Dooremalen Sanne F.J., Westinga Kasper, Admiraal Rick, Lorenowicz Magdalena J, Huls Gerwin, Janssen Jeroen J W M, Broers Annoek E C, van der Velden Walter J F M, van Marwijk Kooy Rien, Hazenberg Mette D, de Haar Colin, Lindemans Caroline, Jan Boelens Jaap, Kuball Jürgen 1 jan 2020, In: Bone Marrow Transplantation. 55 , p. 2188-2192 5 p.

A "No-Touch" Antibody-Staining Method of Adherent Cells for High-Throughput Flow Cytometry in 384-Well Microplate Format for Cell-Based Drug Library Screening

Cornel Annelisa, Szanto Celina, van Velzen Jeroen, Boelens Jaap-Jan, Nierkens Stefan 26 dec 2019, In: Cytometry Part A. 97 , p. 845-851 7 p.

Peripheral neuropathy in metachromatic leukodystrophy: current status and future perspective

Beerepoot Shanice, Nierkens Stefan, Boelens Jaap-Jan, Lindemans Caroline, Bugiani Marianna, Wolf Nicole I. 4 nov 2019, In: Orphanet Journal of Rare Diseases. 14

Harmonization of Busulfan Plasma Exposure Unit (BPEU):A Community-Initiated Consensus Statement

McCune Jeannine S, Quinones Christine M, Ritchie James, Carpenter Paul A, van Maarseveen Erik, Yeh Rosa F, Anasetti Claudio, Boelens Jaap J, Hamerschlak Nelson, Hassan Moustapha, Kang Hyoung Jin, Kanda Yoshinobu, Paci Angelo, Perales Miguel-Angel, Shaw Peter J, Seewaldt Victoria L, Savani Bipin N, Hsieh Angela, Poon Betsy, Mohty Mohamad, Pulsipher Michael A, Pasquini Marcelo, Dupuis L Lee sep 2019, In: Biology of Blood and Marrow Transplantation. 25 , p. 1890-1897 8 p.

Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes

Langenhorst J. B., van Kesteren C., van Maarseveen E. M., Dorlo T. P. C., Nierkens Stefan, Lindemans C. A., de Witte M. A., van Rhenen A., Raijmakers R., Bierings M., Kuball J., Huitema A. D. R., Boelens J. J. 23 jul 2019, In: Blood Advances. 3 , p. 2179-2187 9 p.

Predictors for Autoimmune Cytopenias after Allogeneic Hematopoietic Cell Transplantation in Children

Szanto Celina L, Langenhorst Jurgen, de Koning Coco, Nierkens Stefan, Bierings Marc, Huitema Alwin D R, Lindemans Caroline A, Boelens Jaap J 22 jul 2019, In: Biology of Blood and Marrow Transplantation. 26 , p. 114-122 9 p.

Hematopoietic stem cell transplantation for CD40 ligand deficiency:Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study

Ferrua Francesca, Galimberti Stefania, Courteille Virginie, Slatter Mary Anne, Booth Claire, Moshous Despina, Neven Benedicte, Blanche Stephane, Cavazzana Marina, Laberko Alexandra, Shcherbina Anna, Balashov Dmitry, Soncini Elena, Porta Fulvio, Al-Mousa Hamoud, Al-Saud Bandar, Al-Dhekri Hasan, Arnaout Rand, Formankova Renata, Bertrand Yves, Lange Andrzej, Smart Joanne, Wolska-Kusnierz Beata, Aquino Victor M., Dvorak Christopher C., Fasth Anders, Fouyssac Fanny, Heilmann Carsten, Hoenig Manfred, Schuetz Catharina, Kelečić Jadranka, Bredius Robbert G.M., Lankester Arjan C., Lindemans Caroline A., Suarez Felipe, Sullivan Kathleen E., Albert Michael H., Kałwak Krzysztof, Barlogis Vincent, Bhatia Monica, Bordon Victoria, Czogala Wojciech, Alonso Laura, Dogu Figen, Gozdzik Jolanta, Ikinciogullari Aydan, Kriván Gergely, Ljungman Per, Meyts Isabelle, Boelens Jaap Jan, 1 jun 2019, In: Journal of Allergy and Clinical Immunology. 143 , p. 2238-2253 16 p.

All Research Output (254)