dr. M.L. (Marianne) Boes

dr. M.L. (Marianne) Boes

Associate Professor
dr. M.L. (Marianne) Boes
  • Medical Management



Marianne Boes heads the pediatric immunology laboratory at the UMC Utrecht, embedded in the Center for Translational Immunology. Her team focuses on approaches for harnessing the strength of the immune response and its promise to redirection using immune response modification, as preventive or therapeutic medicine. Boes trained in the USA in immunology and cell biology research (1996-2008). She performed PhD research at Massachusetts Institute of Technology (MIT), at the Koch Institute for integrative Cancer Research under supervision of prof. Jianzhu Chen. Here she studied immunodeficiency mechanisms using mouse models. Postdoctoral work she performed at Harvard Medical School in the laboratory of prof. Hidde Ploegh.

In 2004, Dr. Boes started her independent research lab at Brigham and Women’s Hospital/Harvard Medical School, financed in part by an NWO-Veni grant in 2004 and a large NIH-RO1 grant that was awarded to her.  She is the founding chair of the Young Academy of the UMC Utrecht (chair Sept 2019-Jan 2022) and board member of the CUCo working group of the Young Academies of the Strategic Alliance between TU-Eindhoven, Wageningen, Utrecht University and UMC-Utrecht, 2019-2022. Boes serves as coordinator of the course 'Advanced Immunology' and van Kinsbergen Advanced+ Immunology for PhD students. She is current member of the I&I graduate school teaching committee and the Board of Examiners, subcommittee Assessment Support Panel (ASP) @ GSLS-life Sciences Academy. She thoroughly enjoys to meet and learn from researchers, patients and societal partners in different fields. 

Side Activities

Scientific Advisory Board Member at Dutch Diabetes Research Foundation (Diabetes Fonds), June 2022-May 2026 (no payment)

Clinical Fellows program at ZonMw, vice-chair, 2019-current (< €1000)

IDSCOVA mRNA vaccination study LUMC (Establishing the tolerability, safety and immunogenicity of intradermal delivery of a mNRA SARS-CoV-2 vaccine in healthy adults), DSMB member, 2020-2021 (no payment)

Immunotherapy Advances (Oxford Academic Press), deputy-editor: 2019-current (< €1000)

Immunology Letters (Elsevier), section editor: 2022-current (< €1000)


Fellowship and Awards


Jan 2024 - Dec 2028: Horizon-HLTH CLARITY: 7 million euro/5 years (coordinator of consortium and PI)

2021-2023: EWUU-Unusual Collaboration grant; ±160K euro/yr (co-PI)

2022: PhD incentive Radboud University / UMC Utrecht, 270 KEuro (PI)

2021: Actuate grant 200K dollar (PI)

2019: Lymph&co 385K (PI)

2018: Nutricia 47.5K (co-PI)

2015: UU Life Sciences Seed grant 100K (co-PI)

2014: NWO-PhD grant 250K (I&I graduate school UU)

2014: Diabetes Fonds Nederland 250K (co-PI)

2010: ERC-Marie Curie 80K (PI)

2007: NIH-RO1 grant 750K (PI)

2004: NWO-Veni 250K (PI)

2001: Cancer Research Institute/ Irvington fellowship 300K (PI)

1997: Boehringer Ingelheim PhD fellowship 250K (PI)












Research Output (174)

Mycoplasma pneumoniae carriage in children with recurrent respiratory tract infections is associated with a less diverse and altered microbiota

Koenen Mischa H, de Groot Ruben C A, de Steenhuijsen Piters Wouter A A, Chu Mei Ling J N, Arp Kayleigh, Hasrat Raïza, de Bruijn Ad C J M, Estevão Silvia C, van der Vries Erhard, Langereis Jeroen D, Boes Marianne, Bogaert Debby, van Rossum Annemarie M C, Unger Wendy W J, Verhagen Lilly M 9 Nov 2023, In: EBioMedicine. 98 14 p.

MHC II-EGFP Knock-in Mouse Model

Pačes Jan, Grobárová Valéria, Zadražil Zdeněk, Knížková Karolina, Malinská Nikola, Tušková Liliana, Boes Marianne, Černý Jan Nov 2023, In: Current Protocols. 3

Antibody deficiencies in children are associated with prematurity and a family history of infections

Koenen Mischa H, van Montfrans Joris M, Prevaes Sabine M P J, van Engelen Martine P, van der Vries Erhard, Boes Marianne, Sanders Elisabeth A M, Bogaert Debby, Verhagen Lilly M 25 Jul 2023, In: Pediatric Research. 94 , p. 2047-2053 7 p.

Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T-cells

Engelen Suzanne E, Ververs Francesca A, Markovska Angela, Lagerholm B Christoffer, Kraaijenhof Jordan M, Yousif Laura Ie, Zurke Yasemin-Xiomara, Gulersonmez Can Mc, Kooijman Sander, Goddard Michael, van Eijkeren Robert J, Jervis Peter J, Besra Gurdyal S, Haitjema Saskia, Asselbergs Folkert W, Kalkhoven Eric, Ploegh Hidde L, Boes Marianne, Cerundolo Vincenzo, Hovingh G Kees, Salio Mariolina, Stigter Edwin Ca, Rensen Patrick Cn, Monaco Claudia, Schipper Henk S 28 Mar 2023, In: JCI Insight. 8

No immunological changes after factor VIII product switch:An in depth analysis in haemophilia A patients

Schep Sarah J, Fischer Kathelijn, Boes Marianne, Schutgens Roger E G 2023, In: Haemophilia. 29 , p. 1039-1048 10 p.

Nivolumab plus Brentuximab vedotin +/- bendamustine combination therapy:a safe and effective treatment in pediatric recurrent and refractory classical Hodgkin lymphoma

Greve Patrick, Beishuizen Auke, Hagleitner Melanie, Loeffen Jan, Veening Margreet, Boes Marianne, Peperzak Victor, Diez Claudius, Meyer-Wentrup Friederike 2023, In: Frontiers in Immunology. 14

Regulatory T cells in psoriatic arthritis:an IL-17A-producing, Foxp3<sup>int</sup>CD161 + RORγt + ICOS + phenotype, that associates with the presence of ADAMTSL5 autoantibodies

Pouw J. N.Juliëtte, Nordkamp M. A.M.Michel Olde, van Kempen T. Tessa, Concepcion A. N.Arno, van Laar J. M.Jacob, van Wijk F. Femke, Spierings J. Julia, Leijten E. F.A.Emmerik, Boes M. Marianne Dec 2022, In: Scientific Reports. 12

MHC II - EGFP knock-in mouse model is a suitable tool for systems and quantitative immunology

Pačes Jan, Knížková Karolina, Tušková Liliana, Grobárová Valéria, Zadražil Zdeněk, Boes Marianne, Černý Jan 2 Nov 2022, In: Immunology Letters. 251-252 , p. 75-85 11 p.

Preclinical Aortic Atherosclerosis in Adolescents With Chronic Disease

Ververs Francesca A, Eikendal Anouk L M, Kofink Daniel, Nuboer Roos, Westenberg Jos J M, Hovenkamp Gijs T, Kemps Jitske J A, Coenen Iris C J, Daems Joëlle J N, Claus Laura R, Ju Yillie, Wulffraat Nico M, van der Ent Cornelis K, Monaco Claudia, Boes Marianne, Leiner Tim, Grotenhuis Heynric B, Schipper Henk S 19 Jul 2022, In: Journal of the American Heart Association. 11 , p. 1-18

Activation-induced colocalisation of SCAMP5 with IFNα in human plasmacytoid dendritic cells

Pouw Juliëtte N, Olde Nordkamp Michel A M, O'Toole Tom G, Radstake Timothy R D J, Leijten Emmerik F A, Boes Marianne 16 Mar 2022, In: Lupus science & medicine. 9 , p. 1-3

All research output

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