dr. M.L. (Marianne) BoesAssociate Professor
- Laboratory for Translational Immunology (LTI)
- Immunology research 1
Marianne Boes trained in the USA in immunology and cell biology research (1996-2008). She performed PhD research at Massachusetts Institute of Technology (MIT), at the Koch Institute for integrative Cancer Research under supervision of prof. Jianzhu Chen. Here she studied immunodeficiency mechanisms using mouse models. Postdoctoral work she performed at Harvard Medical School in the laboratory of prof. Hidde Ploegh, where she discovered the rapid and dynamic endosomal remodeling process in dendritic cells that occurs immediately upon antigen-specific T-cell contact (Boes et al, Nature 2002). In 2004, Dr. Boes started her independent research lab at Brigham and Women’s Hospital/Harvard Medical School, financed in part by an NWO-Veni grant in 2004 and a large NIH-RO1 grant that was awarded to her. In 2008, she moved her lab to the UMC-Utrecht.
Boes heads the pediatric immunology laboratory at the Center for Translational Immunology. She published more than 120 articles (H-index approaching 40) in international journals, including Nature, Science, Immunity, J. Exp. Med., Nature Immunology and J. Clin. Invest. She and her group received numerous prestigious national and international grants and awards. Boes serves as associate editor for several journals and is a regular reviewer for most major journals in her field. She is Chair of the Young Academy of the UMC Utrecht and board member of the Center for Unusual Collaborations (as part of the strategic alliance between TU-Eindhoven, Wageningen, Utrecht University and UMC-Utrecht). Boes is Faculty of Medicine-biomedical sciences member of the Education Committee of the Graduate School of Life Sciences (EC-LS), and serves as coordinator of the course 'Advanced Immunology' for PhD students. She is also current member of the I&I graduate school teaching committee, where she chairs the I&I Eijkman seminar committee. She thoroughly enjoys to meet and learn from researchers and societal partners in different fields.
The inadequate use of immune pathways can result in disease, such as exemplified in immunodeficiency patients. Boes focuses research on immune pathways that control leukocyte function. Approaches include the genetic screening of primary immunodeficiency patients and study of hemophilia patients receiving live-long supplementation therapy. The goal is to develop new immune tolerance induction protocols, and to apply new immunotherapies for auto inflammatory and autoimmune disorders such as Juvenile idiopathic arthritis (JIA), and pediatric cancers.
Research in Boes lab is supported financially by grants from NWO, the European Research Council (ERC), the Lymph&co foundation and various industry partners. Boes collaborates with both basic and clinically oriented investigators at the UMC-Utrecht. Several collaborative projects exist with labs elsewhere in Europe and in the USA.
ZonMw member of programma evaluation committee, 2019- current
ZonMw member of scientific evaluation committee, 2020 - current
GSLS staf member educational committee (Faculty of Medicine - Biomedical Sciences), 2017- current
ZonMw member scientific evaluation committee Horizon 2020 grants ERA-NET 2015 and 2016
NVVI member financial committee 'kascommissie' (Dutch Society for Immunology)
AAI member (American Association of Immunologists)
associate editor and frequent reviewer of various immunology and cancer-related journals
2018/2019: member of various PhD thesis defense committees Radboud University, VUMC, AMC and UU
2016-2019: invited speaker: Boston Children's Hospital; FASEB conference (SRC Immunoreceptors, Colorado); Instituto Gulbenkian de Ciência, Portugal; Charles University Prague PhD conference; European Conference of Immunology; European B cell forum 2018 Landshut Germany, IUIS Beijing (also chair).
2020: invited speaker: Vienna Medical University, colloquium in pathophysiology, infectiology and immunology; 14th EFIS-EJI Tatra Immunology Conference, September 19-23, 2020; summer school Bonn University Cluster of Excellence; 50th anniversary meeting of the Scandinavian Society for Immunology
Fellowship and Awards
Boehringer Ingelheim PhD fellowship 1997
Cancer Research Institute Postdoc fellowship 2001
NWO-Veni senior-postdoc fellowship 2004
Harvard Skin Disease Research Center grant 2006
NIH-RO1 grant AR052810 2007
ERC-Marie Curie 2010
MedImmune grant 2011
Fonds NutsOhra 2012
NWO investment subsidy medium 2012
Diabetes Fonds Nederland 2014
NWO-PhD grant (I&I graduate school UU) 2014
Fonds NutsOhra 2015
UU Life Sciences Seed grant 2015
Child Health focus grant 2018
travel awared Beijing IUIS conference 2020
Research Output (155)
Silva-Cardoso Sandra C., Tao Weiyang, Angiolilli Chiara, Lopes Ana P., Bekker Cornelis P. J., Devaprasad Abhinandan, Giovannone Barbara, van Laar Jaap, Cossu Marta, Marut Wioleta, Hack Erik, de Boer Rob J., Boes Marianne, Radstake Timothy R. D. J., Pandit Aridaman 17 sep 2020, In: Frontiers in Immunology. 11
Jansen AJ Gerard, Spaan Thom, Low Hui Zhi, Di lorio Daniele , van den Brand Judith M A, Tieke Malte, Barendrecht Arjan , Rohn Kerstin, van Amerongen Geert, Stittelaar Koert, Baumgartner Wolfgang , Osterhaus Albert D M E, Kuiken Thijs, Boons Geert-Jan, Huskens Jurriaan , Boes Marianne, Maas Coen, van der Vries Erhard 14 jul 2020, In: Blood Advances. 4 , p. 2967-2978 12 p.
Silva-Cardoso Sandra C, Tao Weiyang, Fernández Beatriz Malvar, Boes Marianne, Radstake Timothy R D J, Pandit Aridaman 5 jun 2020, In: European Journal of Immunology. 50 , p. 1598-1601 4 p.
Ohradanova-Repic Anna, Boes Marianne, Stockinger Hannes 24 mrt 2020, In: Frontiers in Immunology. 11
van Kempen Tessa S, Leijten Emmerik F A, Lindenbergh Marthe F S, Nordkamp Michel Olde, Driessen Christoph, Lebbink Robert-Jan, Baerlecken Niklas, Witte Torsten, Radstake Timothy R D J, Boes Marianne 21 mrt 2020, In: European Journal of Immunology. 50 , p. 1209-1219 11 p.
Lindenbergh Marthe F S, Wubbolts Richard, Borg Ellen G F, van 't Veld Esther M, Boes Marianne, Stoorvogel W 1 jan 2020, In: Journal of Extracellular Vesicles. 9
Pouw Juliëtte, Leijten Emmerik, Radstake Timothy, Boes Marianne 26 nov 2019, In: Clinical Immunology. 211 8 p.
Silva-Cardoso Sandra C., Bekker Cornelis P.J., Boes Marianne, Radstake Timothy R.D.J., Angiolilli Chiara 10 sep 2019, In: Molecular Immunology. 114 , p. 524-534 11 p.
Smits B M, Lelieveld P H C, Ververs F A, Turkenburg M, de Koning C, van Dijk M, Leavis H L, Boelens J J, Lindemans C A, Bloem A C, van de Corput L, van Montfrans J, Nierkens Stefan, van Gijn M E, Geerke D P, Waterham H R, Koenderman L, Boes M 2 aug 2019, In: Clinical Immunology. 212
Shan L, van den Hoogen LL, Meeldijk J., Kok HM, Jongeneel Lieneke H., Boes ML, Wenink MH, Hack C.E., Radstake TRDJ, van Roon Joel A.G., Bovenschen AN 24 mei 2019, In: Clinical and Experimental Rheumatology. 38 , p. 220-226 7 p.