dr. M.G. (Matthijs) Bossong

dr. M.G. (Matthijs) Bossong

Assistant Professor
  • Psychiatry

Research Programs




Curriculum Vitae


Matthijs Bossong studied Biomedical Sciences at Utrecht University. After completing his PhD in Utrecht on the role of the endocannabinoid system in human brain functions relevant for psychiatric disorders, he started his first postdoc position in September 2011 at the Institute of Psychiatry of King’s College London. Here, supported by an NWO Rubicon fellowship, Matthijs worked on two multimodal neuroimaging studies with people at an ultra-high risk for developing psychosis. One of these projects involved a treatment with the cannabinoid compound cannabidiol. In September 2014, he started his second postdoc at the Department of Psychiatry of the UMC Utrecht, where he coordinated a large-scale international multicenter study in which the potential of omega-3 fatty acids in the prevention of psychosis was examined in adolescent at-risk individuals. Supported by both an NWO Veni fellowship and a Rudolf Magnus Young Talent Fellowship, Matthijs is currently working as Assistant Professor on a pharmacological neuroimaging study investigating the impact of cannabidiol treatment on brain function of patients with a psychotic disorder. 



Key Publications


Bossong M.G., Antoniades M., Azis M., Samson C., Quinn B., Bonoldi I., Modinos G., Pérez J., Howes O.D., Stone J., Allen P., McGuire P. (2019) Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis. JAMA Psychiatry 76, 199-207.


Bhattacharyya S., Wilson R., Appiah-Kusi E., O'Neill A., Brammer M., Perez J., Murray R., Allen P., Bossong M.G., McGuire P. (2018) Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis: A Randomized Clinical Trial. JAMA Psychiatry 75, 1107-17.


Iseger T.A., Bossong M.G. (2015) A systematic review of the antipsychotic properties of cannabidiol in humans. Schizophrenia Research 162 (1-3), 153 - 161.


Bossong M.G., Jansma J.M., Van Hell H.H., Jager G., Oudman E., Saliasi E., Kahn R.S., Ramsey N.F. (2012) Effects of Δ9-tetrahydrocannabinol on human working memory function. Biological Psychiatry 71 (8), 693 - 699.


Bossong M.G., Niesink R.J. (2010) Adolescent brain maturation, the endogenous cannabinoid system and cannabis-induced schizophrenia. Progress in Neurobiology 92 (3), 370 - 385.


Bossong M.G., Van Berckel B.N.M., Boellaard R., Zuurman L., Schuit R.C., Windhorst A.D., Van Gerven J.M.A., Ramsey N.F., Lammertsma A.A., Kahn R.S. (2009) ∆9-Tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology 34 (3), 759 - 766.


Van Berckel B.N.M., Bossong M.G., Van Haaren N., Boellaard R., Comans E.F.I., Kloet R., Schuitemaker A., Caspers E., Luurtsema G., Windhorst A.D., Cahn W., Lammertsma A.A., Kahn R.S. (2008) Microglia activation in recent onset schizophrenia: a quantitative (R)-[11C]PK11195 PET study. Biological Psychiatry 64 (9), 820 - 822

Fellowship and Awards

Bossong M.G. Examining synaptic density in the living brain of schizophrenia patients. Rudolf Magnus Young Talent Fellowship, 01/10/2017 - 01/01/2020, €200,000 


Bossong M.G. Endocannabinoid control of microglia activation as a new therapeutic target in the treatment of schizophrenia. Netherlands Organisation for Scientific Research, Fellowship (VENI grant), 01/01/2016 - 01/01/2019, €250,000 


Bossong M.G. Towards prevention of schizophrenia: the potential of a cannabidiol as a novel antipsychotic agent. Netherlands Organisation for Scientific Research, Fellowship (Rubicon grant), 01/05/2012 - 01/05/2014, €144,937 

Research Output (53)

The impact of cannabidiol treatment on resting state functional connectivity, prefrontal metabolite levels and reward processing in recent-onset patients with a psychotic disorder

van Boxel Ruben, Gangadin Shiral S, Janssen Hella, van der Steur Sanne, van der Vinne Lucia J C, Dortants Lon, Pelgrim Teuntje A D, Draisma Luc W R, Tuura Ruth, van der Meer Pim, Batalla Albert, Bossong Matthijs G 13 May 2023, In: Journal of Psychiatric Research. 163 , p. 93-101 9 p.

Therapeutic effect of psilocybin in addiction:A systematic review

van der Meer Pim B., Fuentes Juan J., Kaptein Ad A., Schoones Jan W., de Waal Marleen M., Goudriaan Anneke E., Kramers Kees, Schellekens Arnt, Somers Metten, Bossong Matthijs G., Batalla Albert 9 Feb 2023, In: Frontiers in Psychiatry. 14

The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis

Tognin Stefania, Richter Anja, Kempton Matthew J., Modinos Gemma, Antoniades Mathilde, Azis Matilda, Allen Paul, Bossong Matthijs G., Perez Jesus, Pantelis Christos, Nelson Barnaby, Amminger G. Paul, Riecher-Rössler Anita, Barrantes-Vidal Neus, Krebs Marie Odile, Glenthøj Birte, Ruhrmann Stephan, Sachs Gabriele, Rutten Bart P., De Haan Lieuwe, Van Der Gaag Mark, Mcguire Philip, Valmaggia Lucia R., Calem Maria, Antoniades Mathilde, Pisani Sara, Modinos Gemma, De Haan Lieuwe, Van Der Gaag Mark, Velthorst Eva, Kraan Tamar C., Van Dam Daniella S., Burger Nadine, Nelson Barnaby, Mcgorry Patrick, Amminger G. Paul, Pantelis Christos, Politis Athena, Goodall Joanne, Riecher-Rössler Anita, Borgwardt Stefan, Studerus Erich, Bressan Rodrigo, Gadelha Ary, Brietzke Elisa, Asevedo Graccielle, Asevedo Elson, Zugman Andre, Van Os Jim, 1 Jan 2022, In: Schizophrenia Bulletin Open. 3

Reduced resting state functional connectivity in the hippocampus-midbrain-striatum network of schizophrenia patients

Gangadin Shiral S, Cahn Wiepke, Scheewe Thomas W, Hulshoff Pol Hilleke E, Bossong Matthijs G 26 Mar 2021, In: Journal of Psychiatric Research. 138 , p. 83-88 6 p.

The Impact of Cannabidiol on Human Brain Function:A Systematic Review

Batalla Albert, Bos Julian, Postma Amber, Bossong Matthijs G. 21 Jan 2021, In: Frontiers in Pharmacology. 11 15 p.

Integrated metastate functional connectivity networks predict change in symptom severity in clinical high risk for psychosis

Gifford George, Crossley Nicolas, Morgan Sarah, Kempton Matthew J, Dazzan Paola, Modinos Gemma, Azis Matilda, Samson Carly, Bonoldi Ilaria, Quinn Beverly, Smart Sophie E, Antoniades Mathilde, Bossong Matthijs G, Broome Matthew R, Perez Jesus, Howes Oliver D, Stone James M, Allen Paul, Grace Anthony A, McGuire Philip 13 Oct 2020, In: Human Brain Mapping. 42 , p. 439-451 13 p.

A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis

Davies Cathy, Wilson Robin, Appiah-Kusi Elizabeth, Blest-Hopley Grace, Brammer Michael, Perez Jesus, Murray Robin M, Allen Paul, Bossong Matthijs G, McGuire Philip, Bhattacharyya Sagnik 13 Sep 2020, In: Translational Psychiatry. 10 , p. 1-12

Glutamate in schizophrenia:Neurodevelopmental perspectives and drug development

Egerton Alice, Grace Anthony A, Stone James, Bossong Matthijs G, Sand Michael, McGuire Philip Sep 2020, In: Schizophrenia Research. 223 , p. 59-70 12 p.

Do the effects of cannabis on the hippocampus and striatum increase risk for psychosis?

Daniju Y, Bossong M G, Brandt K, Allen P May 2020, In: Neuroscience and Biobehavioral Reviews. 112 , p. 324-335 12 p.

Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association With Clinical Outcome

Modinos Gemma, Allen Paul, Zugman Andre, Dima Danai, Azis Matilda, Samson Carly, Bonoldi Ilaria, Quinn Beverly, Gifford George W. G., Smart Sophie E., Antoniades Mathilde, Bossong Matthijs G., Broome Matthew R., Perez Jesus, Howes Oliver D., Stone James M., Grace Anthony A., McGuire Philip 10 Apr 2020, In: Schizophrenia bulletin. 46 , p. 670-679 10 p.

All research output

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