prof. dr. M.L. (Michiel L.) Bots Full Professor

Department of Epidemiology
Julius Center Research Program Cardiovascular Epidemiology

Contact

m.bots@umcutrecht.nl

Research programs

Circulatory Health

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

In 1986, Michiel Bots received his medical degree at the Erasmus University in Rotterdam. After working as a resident in Gynaecology and Obstetrics, at the Hospital Zonnegloren in Soest and as a resident in Surgery at the Juliana Hospital in Apeldoorn, he started in 1988 his training in cardiovascular epidemiology started at the Department of Epidemiology & Biostatistics of the Erasmus University Medical School in Rotterdam.
In 1993, he obtained his PhD degree on the thesis entitled 'Carotid wall thickness as indicator of generalised atherosclerosis'.
In 1996 he moved to the Julius Center for Health Sciences and Primary Care of the University Medical Center Utrecht in Utrecht.
Since 1997 he serves as Managing (up to 2001) and Scientific director of Vascular Imaging Center Utrecht, a vascular core laboratory on quantification of structural, dynamic and functional arterial characteristics.
In 2001 he was appointed associate professor in epidemiology
Since 2009 he is a professor in the Epidemiology of Cardiovascular Disease at the University Medical Center Utrecht, Utrecht, The Netherlands.
Since 2013 he is chariman of the steering committe of the Utrecht Cardiovascular Cohort: a multidisciplinary effort with physicians, patients and researchers of the UMC Utrecht, the UCC sets a benchmark for a learning cardiovascular healthcare system. UCC offers an invaluable resource for future high quality care as well as for first-class research for investigators.

His research activities comprise observational studies and clinical trials

around the development of atherosclerosis, its physiological and environmental risk factors and its consequences. Non-invasive assessment of atherosclerotic abnormalities through imaging in both high risk and low risk populations by measurement of carotid intima-media thickness, carotid plaque, arterial stiffness, coronary calcifications, coronary stenosis and their progression over time are major topics in his studies.
around uncontrolled hypertension elevated blood pressure and treatment thereof
around kidney disease and its determinants and therapies, with a main focus on dialysis patients and treatment modalities
around facts and figure of cardiovascular disease in the Netherlands, with an emphasis on national data obtainable through linkage of registries.
around the creation of an infrastructure for uniform registration of cardiovascular information in routine clinical practice for patients referred for cardiovascular care at the University Medical Center Utrecht, the Netherlands

His scientific output involves over 500 international peer reviewed publications.

His teaching activities involve

Regular curricular lectures on cardiovascular and general clinical epidemiology for biomedical and pharmaceutical bachelor and master students.
Coordinator of the annual MSc course 'Cardiovascular Epidemiology' (www.msc-epidemiology.nl)
Coordinator of the annual Blended MSc course ‘Epidemiology of Cardiovascular Disease’ (https://elearning.elevatehealth.eu/)
Regularly a MSc course 'Clinical Epidemiology' outside the Netherlands (China, Germany, Malaysia)

Side Activities

Member Scientific Committee on Senior POSTDOCs grants of the Netherlands Heart Foundation.

Advisory board for the working party on ‘Cardiovascular disease: figures and facts’ of the Dutch Heart Foundation,

Editor of European Journal of Preventive Cardiology.

Editorial board of Journal of Hypertension.

Member Medical Ethics Committee of the UMC Utrecht.

Incidental member on advisory boards of profit organizations on studies into imaging of atherosclerosis progression

Research Output

Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis: The SMART-MR Study

Zwartbol M. H. T., Geerlings M. I., Ghaznawi R., Hendrikse J., van der Kolk A. G., Asselbergs F. W., Nathoe H. M., de Borst G. J., Bots M. L., Emmelot M. H., de Jong P. A., Leiner T., Lely A. T., van der Kaaij N. P., Kappelle L. J., Ruigrok Y. M., Verhaar M. C., Visseren F. L. J., Westerink J., 5 Dec 2019 In: American Journal of Neuroradiology. 40, p. 2016-2022 7 p.

Cardiovascular disease risk in an urban African population: a cross-sectional analysis on the role of HIV and antiretroviral treatment

Vos Alinda G, Hoeve Klariska, Barth Roos E, Peper Joyce, Moorhouse Michelle, Crowther Nigel J, Venter Willem D F, Grobbee Diederick E, Bots Michiel L, Klipstein-Grobusch Kerstin 3 Dec 2019 In: Retrovirology. 16 10 p.

Adverse differences in cardiometabolic risk factor levels between individuals with pre-diabetes and normal glucose metabolism are more pronounced in women than in men: The Maastricht Study

De Ritter Rianneke, Sep Simone J.S., Van Der Kallen Carla J.H., Schram Miranda T., Koster Annemarie, Kroon Abraham A., Van Greevenbroek Marleen M.J., Eussen Simone J.P.M., Dagnelie Pieter C., De Jong Marit, Vos Rimke C., Woodward Mark, Bots Michiel L., Peters Sanne A.E., Stehouwer Coen D.A. 15 Nov 2019 In: BMJ Open Diabetes Research and Care. 7

Frequent Cognitive Impairment in Patients With Disorders Along the Heart-Brain Axis

Hooghiemstra Astrid M, Leeuwis Anna E, Bertens Anne Suzannne, Biessels Geert Jan, Bots Michiel L, Brunner-La Rocca Hans-Peter, Greving Jacoba P, Kappelle L Jaap, van Oostenbrugge Robert J, van Rossum Albert C, van der Flier Wiesje M, 5 Nov 2019 In: Stroke. 50, p. 3369-3375 7 p.

Corrigendum: Normal Values of Corrected Heart-Rate Variability in 10-Second Electrocardiograms for All Ages

van den Berg Marten E., Rijnbeek Peter R., Niemeijer Maartje N., Hofman Albert, van Herpen Gerard, Bots Michiel L., Hillege Hans, Swenne Cees A., Eijgelsheim Mark, Stricker Bruno H., Kors Jan A. 1 Nov 2019 In: Frontiers in Physiology. 10

Risk factors for in-hospital mortality in patients with dementia

Golüke Nienke M S, van de Vorst Irene E, Vaartjes Ilonca H, Geerlings Mirjam I, de Jonghe Annemarieke, Bots Michiel L, Koek Huiberdina L Nov 2019 In: Maturitas. 129, p. 57-61 5 p.

Hart- en vaatziekten in Nederland 2019: 25 jaar cijfers over incidentie, prevalentie, ziekte en sterfte.

Bots Michael L, de Boer Annemarijn, Vaartjes Ilonca Nov 2019 25 148 p.

Normal Values of QT Variability in 10-s Electrocardiograms for all Ages

van den Berg Marten E., Kors Jan A., van Herpen Gerard, Bots Michiel L., Hillege Hans, Swenne Cees A., Stricker Bruno H., Rijnbeek Peter R. 4 Oct 2019 In: Frontiers in Physiology. 10 7 p.

Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients

Heidt Sebastiaan, Haasnoot Geert W., Witvliet Marian D., van der Linden-van Oevelen Marissa J.H., Kamburova Elena G., Wisse Bram W., Joosten Irma, Allebes Wil A., van der Meer Arnold, Hilbrands Luuk B., Baas Marije C., Spierings Eric, Hack Cornelis E., van Reekum Franka E., van Zuilen Arjan D., Verhaar Marianne C., Bots Michiel L., Drop Adriaan C.A.D., Plaisier Loes, Seelen Marc A.J., Sanders Jan Stephan, Hepkema Bouke G., Lambeck Annechien J.A., Bungener Laura B., Roozendaal Caroline, Tilanus Marcel G.J., Voorter Christina E., Wieten Lotte, van Duijnhoven Elly M., Gelens Marielle A.C.J., Christiaans Maarten H.L., van Ittersum Frans J., Nurmohamed Shaikh A., Lardy Neubury M., Swelsen Wendy, van der Pant Karlijn A.M.I., van der Weerd Neelke C., ten Berge Ineke J.M., Bemelman Frederike J., Hoitsma Andries, van der Boog Paul J.M., de Fijter Johan W., Betjes Michiel G.H., Otten Henny G., Roelen Dave L., Claas Frans H.J. Oct 2019 In: American Journal of Transplantation. 19, p. 2926-2933 8 p.

Geriatric Assessment and the Relation with Mortality and Hospitalizations in Older Patients Starting Dialysis

van Loon Ismay N, Goto Namiko A, Boereboom Franciscus T J, Bots Michiel L, Hoogeveen Ellen K, Gamadia Laila, van Bommel E F H, van de Ven P J G, Douma Caroline E, Vincent H H, Schrama Yvonne C, Lips Joy, Siezenga Machiel A, Abrahams Alferso C, Verhaar Marianne C, Hamaker Marije E 13 Aug 2019 In: Nephron. 143, p. 108-119 12 p.

All Research Output (823)

Fellowship and Awards

Over the years Michiel Bots was involved in national and international collaborations that were successful in obtaining grants proposal from profit (pharmaceutical industry) and non profit organisations (ZonMw, Netherlands Heart Foundation, European Union, Dutch Kidney Foundation, CVON-HF).