prof. dr. M.L. (Michiel L.) Bots

prof. dr. M.L. (Michiel L.) Bots

Full Professor
prof. dr. M.L. (Michiel L.) Bots
  • Department of Epidemiology
  • Department of Epidemiology
  • Julius Center Research Program Cardiovascular Epidemiology

Research Programs

Circulatory Health




  • In 1986, Michiel Bots received his medical degree at the Erasmus University in Rotterdam. After working as a resident in Gynaecology and Obstetrics, at the Hospital Zonnegloren in Soest and as a resident in Surgery at the Juliana Hospital in Apeldoorn, he started in 1988 his training in cardiovascular epidemiology started at the Department of Epidemiology & Biostatistics of the Erasmus University Medical School in Rotterdam.
  • In 1993, he obtained his PhD degree on the thesis entitled 'Carotid wall thickness as indicator of generalised atherosclerosis'.
  • In 1996 he moved to the Julius Center for Health Sciences and Primary Care of the University Medical Center Utrecht in Utrecht.
  • Since 1997 he serves as Managing (up to 2001) and Scientific director of Vascular Imaging Center Utrecht, a vascular core laboratory on quantification of structural, dynamic and functional arterial characteristics.
  • In 2001 he was appointed associate professor in epidemiology
  • Since 2009 he is a professor in the Epidemiology of Cardiovascular Disease at the University Medical Center Utrecht, Utrecht, The Netherlands.
  • Since 2013 he is chariman of the steering committe of the Utrecht Cardiovascular Cohort: a multidisciplinary effort with physicians, patients and researchers of the UMC Utrecht, the UCC sets a benchmark for a learning cardiovascular healthcare system. UCC offers an invaluable resource for future high quality care as well as for first-class research for investigators.

 His research activities comprise observational studies and clinical trials

  • around the development of atherosclerosis, its physiological and environmental risk factors and its consequences. Non-invasive assessment of atherosclerotic abnormalities through imaging in both high risk and low risk populations by measurement of carotid intima-media thickness, carotid plaque, arterial stiffness, coronary calcifications, coronary stenosis and their progression over time are major topics in his studies.
  • around uncontrolled hypertension elevated blood pressure and treatment thereof
  • around kidney disease and its determinants and therapies, with a main focus on dialysis patients and treatment modalities
  • around facts and figure of cardiovascular disease in the Netherlands, with an emphasis on national data obtainable through linkage of registries.
  • around the creation of an infrastructure for uniform registration of cardiovascular information in routine clinical practice for patients referred for cardiovascular care at the University Medical Center Utrecht, the Netherlands

 His scientific output involves over 750 international peer reviewed publications.

 His teaching activities involve

  • Regular curricular lectures on cardiovascular and general clinical epidemiology for medicine, biomedical and pharmaceutical bachelor and master students.

  • Coordinator of the annual MSc course 'Cardiovascular Epidemiology' (

  • Coordinator of the annual Blended MSc course ‘Epidemiology of Cardiovascular Disease’ (

  • Regularly a MSc course 'Clinical Epidemiology' outside the Netherlands (China, Germany, Malaysia) 


Side Activities

Advisory board for the working party on ‘Cardiovascular disease: figures and facts’ of the Dutch Heart Foundation,


Fellowship and Awards

Over the years Michiel Bots was involved in national and international collaborations that were successful in obtaining grants proposal from profit (pharmaceutical industry) and non profit organisations (ZonMw, Netherlands Heart Foundation, European Union, Dutch Kidney Foundation, CVON-HF).


Research Output (981)

Stepwise implementation of a cardiovascular risk management care program in primary care

Smits Geert, Romeijnders A., Rozema H., Wijnands C., Hollander Monika, van Doorn Sander, Bots Michiel, Dec 2022, In: BMC Primary Care. 23

Evidence for pharmacological interventions to reduce cardiovascular risk for patients with chronic kidney disease:a study protocol of an evidence map

Colombijn Julia M.T., Idema Demy L., van der Braak Kim, Spijker Rene, Meijvis Sabine C.A., Bots Michiel L., Hooft Lotty, Verhaar Marianne C., Vernooij Robin W.M. 12 Nov 2022, In: Systematic Reviews. 11

Carotid tortuosity is associated with extracranial carotid artery aneurysms

van Laarhoven Constance J.H.C.M., Willemsen Saskia I., Klaassen Jurre, de Vries Evelien E., van der Vliet Quirine M.J., Hazenberg Constantijn E.V.B., Bots Michiel L., de Borst Gert J. Nov 2022, In: Quantitative Imaging in Medicine and Surgery. 12 , p. 5018-5029 12 p.

Data mining to retrieve smoking status from electronic health records in general practice

de Boer Annemarijn, de Groot Mark, Groenhof Katrien, van Doorn Sander, Vaartjes Ilonca, Bots Michael L, Haitjema Saskia 3 Oct 2022, In: European Heart Journal Digital Health. 3 , p. 437-444

Smartphone Application-Assisted Home Blood Pressure Monitoring Compared With Office and Ambulatory Blood Pressure Monitoring in Patients With Hypertension:the AMUSE-BP Study

Groenland Eline H., Vendeville Jean Paul A.C., Bemelmans Remy H.H., Monajemi Houshang, Bots Michiel L., Visseren Frank L.J., Spiering Wilko 1 Oct 2022, In: Hypertension. 79 , p. 2373-2382 10 p.

Rosuvastatin Slows Progression of Carotid Intima-Media Thickness:The METEOR-China Randomized Controlled Study

Zheng Huaguang, Li Hongwei, Wang Yilong, Li Zhanquan, Hu Bo, Li Xiaogang, Fu Lu, Hu Hongtao, Nie Zhiyu, Zhao Bilian, Wei Di, Karlson Björn W., Bots Michiel L., Meng Xiang Wen, Chen Yundai, Wang Yongjun Oct 2022, In: Stroke. 53 , p. 3004-3013 10 p.

Clinical characteristics do not reliably identify non-adherence in patients with uncontrolled hypertension

Groenland Eline H., Dasgupta Indranil, Visseren Frank L.J., van der Elst Kim C.M., Lorde Nathan, Lawson Alexander J., Bots Michiel L., Spiering Wilko 27 Jul 2022, In: Blood pressure. 31 , p. 178-186 9 p.

Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima-Media Thickness:An Individual Participant Data Meta-Analysis

Nonterah Engelbert A, Crowther Nigel J, Klipstein-Grobusch Kerstin, Oduro Abraham R, Kavousi Maryam, Agongo Godfred, Anderson Todd J, Asiki Gershim, Boua Palwendé R, Choma Solomon S R, Couper David J, Engström Gunnar, de Graaf Jacqueline, Kauhanen Jussi, Lonn Eva M, Mathiesen Ellisiv B, Micklesfield Lisa K, Okazaki Shuhei, Polak Joseph F, Rundek Tatjana, Salonen Jukka T, Tollman Stephen M, Tuomainen Tomi-Pekka, Grobbee Diederick E, Ramsay Michéle, Bots Michiel L, 25 Jul 2022, In: Journal of the American Heart Association. 11

Pre-screening to guide coronary artery calcium scoring for early identification of high-risk individuals in the general population

Ties Daan, van der Ende Yldau M, Pundziute Gabija, van der Schouw Yvonne T, Bots Michiel L, Xia Congying, van Ooijen Peter M A, Pelgrim Gert Jan, Vliegenthart Rozemarijn, van der Harst Pim 19 Jul 2022, In: European Heart Journal Cardiovascular Imaging. 24 , p. 27-35 9 p.

Opinions on hypertension care and therapy adherence at the healthcare provider and healthcare system level:a qualitative study in the Hague, Netherlands

Van Grondelle Saskia E., Van Bruggen Sytske, Meijer Judith, Van Duin Erik, Bots Michiel L., Rutten Guy, Vos Hedwig M.M., Numans Mattijs E., Vos Rimke C. 8 Jul 2022, In: BMJ Open. 12

All research output

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