prof. dr. M.L. (Michiel L.) Bots Full Professor

Department of Epidemiology
Julius Center Research Program Cardiovascular Epidemiology

Contact

m.bots@umcutrecht.nl

Research programs

Circulatory Health

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

In 1986, Michiel Bots received his medical degree at the Erasmus University in Rotterdam. After working as a resident in Gynaecology and Obstetrics, at the Hospital Zonnegloren in Soest and as a resident in Surgery at the Juliana Hospital in Apeldoorn, he started in 1988 his training in cardiovascular epidemiology started at the Department of Epidemiology & Biostatistics of the Erasmus University Medical School in Rotterdam.
In 1993, he obtained his PhD degree on the thesis entitled 'Carotid wall thickness as indicator of generalised atherosclerosis'.
In 1996 he moved to the Julius Center for Health Sciences and Primary Care of the University Medical Center Utrecht in Utrecht.
Since 1997 he serves as Managing (up to 2001) and Scientific director of Vascular Imaging Center Utrecht, a vascular core laboratory on quantification of structural, dynamic and functional arterial characteristics.
In 2001 he was appointed associate professor in epidemiology
Since 2009 he is a professor in the Epidemiology of Cardiovascular Disease at the University Medical Center Utrecht, Utrecht, The Netherlands.
Since 2013 he is chariman of the steering committe of the Utrecht Cardiovascular Cohort: a multidisciplinary effort with physicians, patients and researchers of the UMC Utrecht, the UCC sets a benchmark for a learning cardiovascular healthcare system. UCC offers an invaluable resource for future high quality care as well as for first-class research for investigators.

His research activities comprise observational studies and clinical trials

around the development of atherosclerosis, its physiological and environmental risk factors and its consequences. Non-invasive assessment of atherosclerotic abnormalities through imaging in both high risk and low risk populations by measurement of carotid intima-media thickness, carotid plaque, arterial stiffness, coronary calcifications, coronary stenosis and their progression over time are major topics in his studies.
around uncontrolled hypertension elevated blood pressure and treatment thereof
around kidney disease and its determinants and therapies, with a main focus on dialysis patients and treatment modalities
around facts and figure of cardiovascular disease in the Netherlands, with an emphasis on national data obtainable through linkage of registries.
around the creation of an infrastructure for uniform registration of cardiovascular information in routine clinical practice for patients referred for cardiovascular care at the University Medical Center Utrecht, the Netherlands

His scientific output involves over 500 international peer reviewed publications.

His teaching activities involve

Regular curricular lectures on cardiovascular and general clinical epidemiology for biomedical and pharmaceutical bachelor and master students.
Coordinator of the annual MSc course 'Cardiovascular Epidemiology' (www.msc-epidemiology.nl)
Coordinator of the annual Blended MSc course ‘Epidemiology of Cardiovascular Disease’ (https://elearning.elevatehealth.eu/)
Regularly a MSc course 'Clinical Epidemiology' outside the Netherlands (China, Germany, Malaysia)

Side Activities

Member Scientific Committee on Senior POSTDOCs grants of the Netherlands Heart Foundation.

Advisory board for the working party on ‘Cardiovascular disease: figures and facts’ of the Dutch Heart Foundation,

Editor of European Journal of Preventive Cardiology.

Editorial board of Journal of Hypertension.

Member Medical Ethics Committee of the UMC Utrecht.

Incidental member on advisory boards of profit organizations on studies into imaging of atherosclerosis progression

Research Output

Association between bone metabolism regulators and arterial stiffness in type 2 diabetes patients

Sharif S., Bots M. L., Schalkwijk C., Stehouwer C. D.A., Visseren F. L.J., Westerink J., Dec 2018 In: Nutrition, Metabolism and Cardiovascular Diseases. 28, p. 1245-1252

Hart- en vaatziekten in Nederland, 2018: Cijfers over risicofactoren, hartinterventies, ziekte en sterfte

de Boer AR, van Dis Ineke, Visseren FLJ, Vaartjes CH, Bots Michael L Nov 2018 132 p.

Cijfers over risicofactoren, hartinterventies, ziekte en sterfte

de Boer AR, van Dis Ineke, Visseren FLJ, Vaartjes CH, Bots Michael L Nov 2018 p. 7-50 44 p.

Role of albumin assay on calcium levels and prescription of phosphate binders in chronic hemodialysis patients

De Roij Van Zuijdewijn Camiel L.M., De Haseth Dinky E., Van Dam Bastiaan, Bax Willem A., Grooteman Muriel P.C., Bots Michiel L., Blankestijn Peter J., Nubé Menso J., Van Den Dorpel Marinus A., Ter Wee Pieter M., Penne Erik L. 1 Oct 2018 In: Nephron. 140, p. 211-217 7 p.

Clinical evidence on haemodiafiltration

Blankestijn Peter J., Grooteman Muriel P., Nube Menso J., Bots Michiel L. 1 Oct 2018 In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 33, p. iii53-iii58

Rationale and design of the extracranial carotid artery aneurysm registry

Welleweerd J C, Bots M L, Kappelle L J, Rinkel G J, Ruigrok Y M, Baas A F, van der Worp H B, Vergouwen M D, Bleys R L, Hendrikse J, Lo T H, Moll F L, de Borst G J Oct 2018 In: Journal of Cardiovascular Surgery. 59, p. 692-698

Routine primary care data for scientific research, quality of care programs and educational purposes: The Julius General Practitioners' Network (JGPN)

Smeets Hugo M, Kortekaas Marlous F, Rutten Frans H, Bots Michiel L, van der Kraan Willem, Daggelders Gerard, Smits-Pelser Hanneke, Helsper Charles W, Hoes Arno W, de Wit Niek J 25 Sep 2018 In: BMC Health Services Research. 18

Pretransplant C3D-fixing donor-specific anti-HLA antibodies are not associated with increased risk for kidney graft failure

Kamburova Elena G., Wisse Bram W., Joosten Irma, Allebes Wil A., Van Der Meer Arnold, Hilbrands Luuk B., Baas Marije C., Spierings Eric, Hack Cornelis E., Van Reekum Franka E., Van Zuilen Arjan D., Verhaar Marianne C., Bots Michiel L., Drop Adriaan C.A.D., Plaisier Loes, Seelen Marc A.J., Sanders Jan Stephan, Hepkema Bouke G., Lambeck Annechien J.A., Bungener Laura B., Roozendaal Caroline, Tilanus Marcel G.J., Voorter Christina E., Wieten Lotte, Van Duijnhoven Elly M., Gelens Mariëlle A.C.J., Christiaans Maarten H.L., Van Ittersum Frans J., Nurmohamed Shaikh A., Lardy Neubury M., Swelsen Wendy, Van Der Pant Karlijn A.M.I., Van Der Weerd Neelke C., Ten Berge Ineke J.M., Bemelman Frederike J., Hoitsma Andries J., Van Der Boog Paul J.M., De Fijter Johan W., Betjes Michiel G.H., Heidt Sebastiaan, Roelen Dave L., Claas Frans H., Otten Henny G. 1 Sep 2018 In: Journal of the American Society of Nephrology. 29, p. 2279-2285 7 p.

Relations between the residential fast-food environment and the individual risk of cardiovascular diseases in The Netherlands: A nationwide follow-up study

Poelman Maartje, Strak Maciej, Schmitz Oliver, Hoek Gerard, Karssenberg Derek, Helbich Marco, Ntarladima Anna Maria, Bots Michiel, Brunekreef Bert, Grobbee Rick, Dijst Martin, Vaartjes Ilonca 1 Sep 2018 In: European Journal of Preventive Cardiology. 25, p. 1397-1405 9 p.

Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant

Kamburova E. G., Wisse B. W., Joosten I., Allebes W. A., van der Meer A., Hilbrands L. B., Baas M. C., Spierings E., Hack C. E., van Reekum F. E., van Zuilen A. D., Verhaar M. C., Bots M. L., Drop A. C.A.D., Plaisier L., Seelen M. A.J., Sanders J. S.F., Hepkema B. G., Lambeck A. J.A., Bungener L. B., Roozendaal C., Tilanus M. G.J., Voorter C. E., Wieten L., van Duijnhoven E. M., Gelens M., Christiaans M. H.L., van Ittersum F. J., Nurmohamed S. A., Lardy N. M., Swelsen W., van der Pant K. A., van der Weerd N. C., ten Berge I. J.M., Bemelman F. J., Hoitsma A., van der Boog P. J.M., de Fijter J. W., Betjes M. G.H., Heidt S., Roelen D. L., Claas F. H., Otten H. G. Sep 2018 In: American Journal of Transplantation. 18, p. 2274-2284

All Research Output (742)

Fellowship and Awards

Over the years Michiel Bots was involved in national and international collaborations that were successful in obtaining grants proposal from profit (pharmaceutical industry) and non profit organisations (ZonMw, Netherlands Heart Foundation, European Union, Dutch Kideny Foundation, CVON-HF).