prof. dr. M.L. (Michiel L.) Bots Full Professor

Department of Epidemiology
Julius Center Research Program Cardiovascular Epidemiology

Contact

m.bots@umcutrecht.nl

Research programs

Circulatory Health

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

In 1986, Michiel Bots received his medical degree at the Erasmus University in Rotterdam. After working as a resident in Gynaecology and Obstetrics, at the Hospital Zonnegloren in Soest and as a resident in Surgery at the Juliana Hospital in Apeldoorn, he started in 1988 his training in cardiovascular epidemiology started at the Department of Epidemiology & Biostatistics of the Erasmus University Medical School in Rotterdam.
In 1993, he obtained his PhD degree on the thesis entitled 'Carotid wall thickness as indicator of generalised atherosclerosis'.
In 1996 he moved to the Julius Center for Health Sciences and Primary Care of the University Medical Center Utrecht in Utrecht.
Since 1997 he serves as Managing (up to 2001) and Scientific director of Vascular Imaging Center Utrecht, a vascular core laboratory on quantification of structural, dynamic and functional arterial characteristics.
In 2001 he was appointed associate professor in epidemiology
Since 2009 he is a professor in the Epidemiology of Cardiovascular Disease at the University Medical Center Utrecht, Utrecht, The Netherlands.
Since 2013 he is chariman of the steering committe of the Utrecht Cardiovascular Cohort: a multidisciplinary effort with physicians, patients and researchers of the UMC Utrecht, the UCC sets a benchmark for a learning cardiovascular healthcare system. UCC offers an invaluable resource for future high quality care as well as for first-class research for investigators.

His research activities comprise observational studies and clinical trials

around the development of atherosclerosis, its physiological and environmental risk factors and its consequences. Non-invasive assessment of atherosclerotic abnormalities through imaging in both high risk and low risk populations by measurement of carotid intima-media thickness, carotid plaque, arterial stiffness, coronary calcifications, coronary stenosis and their progression over time are major topics in his studies.
around uncontrolled hypertension elevated blood pressure and treatment thereof
around kidney disease and its determinants and therapies, with a main focus on dialysis patients and treatment modalities
around facts and figure of cardiovascular disease in the Netherlands, with an emphasis on national data obtainable through linkage of registries.
around the creation of an infrastructure for uniform registration of cardiovascular information in routine clinical practice for patients referred for cardiovascular care at the University Medical Center Utrecht, the Netherlands

His scientific output involves over 500 international peer reviewed publications.

His teaching activities involve

Regular curricular lectures on cardiovascular and general clinical epidemiology for biomedical and pharmaceutical bachelor and master students.
Coordinator of the annual MSc course 'Cardiovascular Epidemiology' (www.msc-epidemiology.nl)
Coordinator of the annual Blended MSc course ‘Epidemiology of Cardiovascular Disease’ (https://elearning.elevatehealth.eu/)
Regularly a MSc course 'Clinical Epidemiology' outside the Netherlands (China, Germany, Malaysia)

Side Activities

Member Scientific Committee on Senior POSTDOCs grants of the Netherlands Heart Foundation.

Advisory board for the working party on ‘Cardiovascular disease: figures and facts’ of the Dutch Heart Foundation,

Editor of European Journal of Preventive Cardiology.

Editorial board of Journal of Hypertension.

Member Medical Ethics Committee of the UMC Utrecht.

Incidental member on advisory boards of profit organizations on studies into imaging of atherosclerosis progression

Research Output

Classical Cardiovascular Risk Factors and HIV are Associated With Carotid Intima-Media Thickness in Adults From Sub-Saharan Africa: Findings From H3Africa AWI-Gen Study

Nonterah Engelbert A, Boua Palwende R, Klipstein-Grobusch Kerstin, Asiki Gershim, Micklesfield Lisa K, Agongo Godfred, Ali Stuart A, Mashinya Felistas, Sorgho Herman, Nakanabo-Diallo Seydou, Debpuur Cornelius, Kyobutungi Catherine, Alberts Marianne, Norris Shane, Tollman Stephen, Tinto Halidou, Soo Cassandra C, Mukomana Freedom, Hazelhurst Scott, Wade Alisha N, Kahn Kathleen, Oduro Abraham R, Grobbee Diederick E, Sankoh Osman, Ramsay Michèle, Bots Michiel L, Crowther Nigel J, 16 Jul 2019 In: Journal of the American Heart Association. 8

Association of Initiation of Maintenance Dialysis with Functional Status and Caregiver Burden

Goto Namiko A, van Loon Ismay N, Boereboom Franciscus T J, Emmelot-Vonk Marielle H, Willems Hanna C, Bots Michiel L, Gamadia Laila E, van Bommel Eric F H, Van de Ven Peter J G, Douma Caroline E, Vincent Hieronymus H, Schrama Yvonne C, Lips Joy, Hoogeveen Ellen K, Siezenga Machiel A, Abrahams Alferso C, Verhaar Marianne C, Hamaker Marije E 27 Jun 2019 In: Clinical Journal of the American Society of Nephrology.

Antibodies against ARHGDIB are associated with long-term kidney graft loss

Kamburova Elena G, Gruijters Maartje L, Kardol-Hoefnagel Tineke, Wisse Bram W, Joosten Irma, Allebes Wil A, van der Meer Arnold, Hilbrands Luuk B, Baas Marije C, Spierings Eric, Hack Cornelis E, van Reekum Franka E, van Zuilen Arjan D, Verhaar Marianne C, Bots Michiel L, Drop Adriaan C A D, Plaisier Loes, Melchers Rowena C A, Seelen Marc A J, Sanders Jan Stephan, Hepkema Bouke G, Lambeck Annechien J A, Bungener Laura B, Roozendaal Caroline, Tilanus Marcel G J, Voorter Christina E, Wieten Lotte, van Duijnhoven Elly M, Gelens Mariëlle A C J, Christiaans Maarten H L, van Ittersum Frans J, Nurmohamed Shaikh A, Lardy Neubury M, Swelsen Wendy, van der Pant Karlijn A M I, van der Weerd Neelke C, Ten Berge Ineke J M, Hoitsma Andries, van der Boog Paul J M, de Fijter Johan W, Betjes Michiel G H, Heidt Sebastiaan, Roelen Dave L, Claas Frans H, Bemelman Frederike J, Otten Henny G 13 Jun 2019 In: American Journal of Transplantation.

The effect of computerized decision support systems on cardiovascular risk factors: a systematic review and meta-analysis

Groenhof T. Katrien J., Asselbergs Folkert W., Groenwold Rolf H. H., Grobbee Diederick E., Visseren Frank L. J., Bots Michiel L., Asselbergs Folkert W., Nathoe H. M., de Borst G. J., Bots Michiel L., Geerlings M. I., Emmelot M. H., de Jong P. A., Leiner T., Lely A. T., van der Kaaij N. P., Kappelle L. J., Ruigrok Y. M., Verhaar M. C., Visseren Frank L. J., Westerink J. 10 Jun 2019 In: BMC Medical Informatics and Decision Making. 19

Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic

Valstar Gideon B, Bots Sophie H, Groepenhoff Floor, Gohar Aisha, Rutten Frans H, Leiner Tim, Cramer Maarten Jan Maria, Teske Arco J, Suciadi Leonardo P, Menken Roxana, Pasterkamp Gerard, Asselbergs Folkert W, Hofstra Leonard, Bots Michael L, den Ruijter Hester M 5 Jun 2019 In: BMJ Open. 9

Connective Tissue Growth Factor Is Related to All-cause Mortality in Hemodialysis Patients and Is Lowered by On-line Hemodiafiltration: Results from the Convective Transport Study

den Hoedt Claire H, van Gelder Maaike K, Grooteman Muriel P, Nubé Menso J, Blankestijn Peter J, Goldschmeding Roel, Kok Robbert Jan, Bots Michiel L, van den Dorpel Marinus A, Gerritsen Karin G F 13 May 2019 In: Toxins. 11

Trends in the risk of cardiovascular disease in women with breast cancer in a Dutch nationwide cohort study

Buddeke Josefien, Gernaat Sofie A. M., Bots Michiel L., van den Bongard Desiree H. J. G., Grobbee Diederick E., Vaartjes Ilonca, Verkooijen Helena M. May 2019 In: BMJ Open. 9, p. e022664

Quality of life after the initiation of dialysis or maximal conservative management in elderly patients: a longitudinal analysis of the Geriatric assessment in OLder patients starting Dialysis (GOLD) study

van Loon I N, Goto N A, Boereboom F T J, Verhaar M C, Bots M L, Hamaker M E 29 Mar 2019 In: BMC Nephrology. 20

Arterial stiffness as a risk factor for cardiovascular events and all-cause mortality in people with Type 2 diabetes

Sharif S, Visseren F L J, Spiering W, de Jong P A, Bots M L, Westerink J, 28 Mar 2019 In: Diabetic Medicine.

Mortality After First Hospital Admission for Inflammatory Bowel Disease: A Nationwide Registry Linkage Study

Opstelten Jorrit L, Vaartjes Ilonca, Bots Michiel L, Oldenburg Bas 27 Mar 2019 In: Inflammatory bowel diseases.

All Research Output (797)

Fellowship and Awards

Over the years Michiel Bots was involved in national and international collaborations that were successful in obtaining grants proposal from profit (pharmaceutical industry) and non profit organisations (ZonMw, Netherlands Heart Foundation, European Union, Dutch Kideny Foundation, CVON-HF).