prof. dr. M.L. (Michiel L.) Bots Full Professor

Department of Epidemiology
Julius Center Research Program Cardiovascular Epidemiology

Contact

m.bots@umcutrecht.nl

Research programs

Circulatory Health

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

In 1986, Michiel Bots received his medical degree at the Erasmus University in Rotterdam. After working as a resident in Gynaecology and Obstetrics, at the Hospital Zonnegloren in Soest and as a resident in Surgery at the Juliana Hospital in Apeldoorn, he started in 1988 his training in cardiovascular epidemiology started at the Department of Epidemiology & Biostatistics of the Erasmus University Medical School in Rotterdam.
In 1993, he obtained his PhD degree on the thesis entitled 'Carotid wall thickness as indicator of generalised atherosclerosis'.
In 1996 he moved to the Julius Center for Health Sciences and Primary Care of the University Medical Center Utrecht in Utrecht.
Since 1997 he serves as Managing (up to 2001) and Scientific director of Vascular Imaging Center Utrecht, a vascular core laboratory on quantification of structural, dynamic and functional arterial characteristics.
In 2001 he was appointed associate professor in epidemiology
Since 2009 he is a professor in the Epidemiology of Cardiovascular Disease at the University Medical Center Utrecht, Utrecht, The Netherlands.
Since 2013 he is chariman of the steering committe of the Utrecht Cardiovascular Cohort: a multidisciplinary effort with physicians, patients and researchers of the UMC Utrecht, the UCC sets a benchmark for a learning cardiovascular healthcare system. UCC offers an invaluable resource for future high quality care as well as for first-class research for investigators.

His research activities comprise observational studies and clinical trials

around the development of atherosclerosis, its physiological and environmental risk factors and its consequences. Non-invasive assessment of atherosclerotic abnormalities through imaging in both high risk and low risk populations by measurement of carotid intima-media thickness, carotid plaque, arterial stiffness, coronary calcifications, coronary stenosis and their progression over time are major topics in his studies.
around uncontrolled hypertension elevated blood pressure and treatment thereof
around kidney disease and its determinants and therapies, with a main focus on dialysis patients and treatment modalities
around facts and figure of cardiovascular disease in the Netherlands, with an emphasis on national data obtainable through linkage of registries.
around the creation of an infrastructure for uniform registration of cardiovascular information in routine clinical practice for patients referred for cardiovascular care at the University Medical Center Utrecht, the Netherlands

His scientific output involves over 500 international peer reviewed publications.

His teaching activities involve

Regular curricular lectures on cardiovascular and general clinical epidemiology for biomedical and pharmaceutical bachelor and master students.
Coordinator of the annual MSc course 'Cardiovascular Epidemiology' (www.msc-epidemiology.nl)
Coordinator of the annual Blended MSc course ‘Epidemiology of Cardiovascular Disease’ (https://elearning.elevatehealth.eu/)
Regularly a MSc course 'Clinical Epidemiology' outside the Netherlands (China, Germany, Malaysia)

Side Activities

Member Scientific Committee on Senior POSTDOCs grants of the Netherlands Heart Foundation.

Advisory board for the working party on ‘Cardiovascular disease: figures and facts’ of the Dutch Heart Foundation,

Editor of European Journal of Preventive Cardiology.

Editorial board of Journal of Hypertension.

Member Medical Ethics Committee of the UMC Utrecht.

Incidental member on advisory boards of profit organizations on studies into imaging of atherosclerosis progression

Research Output

Short versus long duration of dual antiplatelet therapy following drug-eluting stents: a meta-analysis of randomised trials

Rozemeijer R, Voskuil M, Greving JP, Bots ML, Doevendans PAFM, Stella PR May 2018 In: Netherlands Heart Journal. 26, p. 242-251

Catheter-based renal denervation as therapy for chronic severe kidney-related pain

de Jager RL, Casteleijn Niek F., de Beus E, Bots ML, Vonken EPA, Gansevoort Ron T., Blankestijn PJ 1 Apr 2018 In: Nephrology Dialysis Transplantation. 33, p. 614-619 6 p.

Long-term clinical parameters after switching to nocturnal haemodialysis: a Dutch propensity-score-matched cohort study comparing patients on nocturnal haemodialysis with patients on three-times-a-week haemodialysis/haemodiafiltration

Jansz TT, Özyilmaz Akin, Grooteman Muriel P C, Hoekstra Tiny, Romijn Marieke, Blankestijn PJ, Bots ML, van Jaarsveld Brigit C 8 Mar 2018 In: BMJ open [E]. 8

Geneugelijk CCA, Niemann Matthias, Drylewicz J, van Zuilen AD, Joosten Irma, Allebes Wil A., van der Meer Arnold, Hilbrands Luuk B., Baas Marije C., Hack CE, van Reekum FE, Verhaar MC, Kamburova EG, Bots ML, Seelen M, Sanders Jan Stephan, Hepkema Bouke G., Lambeck Annechien J., Bungener Laura B., Roozendaal Caroline, Tilanus Marcel G.J., Vanderlocht Joris, Voorter Christien E., Wieten Lotte, van Duijnhoven Elly M., Gelens Mariëlle, Christiaans Maarten H.L., van Ittersum Frans J., Nurmohamed Azam, Lardy Junior N.M., Swelsen Wendy, van der Pant Karlijn A., van der Weerd Neelke C., ten Berge Ineke J.M., Bemelman Fréderike J., Hoitsma Andries, van der Boog Paul J.M., de Fijter Johan W., Betjes Michiel G.H., Heidt Sebastiaan, Roelen Dave L., Claas Frans H., Otten HG, Spierings HT 5 Mar 2018 In: Frontiers in Immunology. 9

Blood pressure response to renal denervation is correlated with baseline blood pressure variability: A patient-level meta-Analysis

Persu Alexandre, Gordin Daniel, Jacobs Lotte, Thijs Lutgarde, Bots ML, Spiering W, Miroslawska Atena, Spaak Jonas, Rosa Ján, De Jong Mark R, Berra Elena, Fadl Elmula Fadl Elmula M, Wuerzner Gregoire, Taylor Alison H M, Olszanecka Agnieszka, Czarnecka Danuta, Mark Patrick B, Burnier Michel, Renkin Jean, Kjeldsen Sverre E., Widimský Jiří, Elvan Arif, Kahan Thomas, Steigen Terje K, Blankestijn PJ, Tikkanen Ilkka, Staessen Jan A. 1 Feb 2018 In: Journal of Hypertension. 36, p. 221-229 9 p.

Sex, body mass index, and blood pressure are related to aortic characteristics in healthy, young adults using magnetic resonance vessel wall imaging: the AMBITYON study

Eikendal ALM, den Ruijter HM, Haaring Cees, Saam Tobias, van der Geest Rob J., Westenberg Jos J.M., Bots ML, Hoefer Imo E., Leiner T 1 Feb 2018 In: Magma - Magnetic Resonance Materials In Physics Biology And Medicine. 31, p. 173-182 10 p.

Apparent resistant hypertension and the risk of vascular events and mortality in patients with manifest vascular disease

van der Sande NGC, de Beus E, Bots ML, Voskuil M, Blankestijn PJ, Visseren FLJ, Spiering W, 1 Jan 2018 In: Journal of Hypertension. 36, p. 143–150

Medication adherence in patients with apparent resistant hypertension: findings from the SYMPATHY trial

de Jager RL, van Maarseveen Erik M., Bots ML, Blankestijn PJ, 1 Jan 2018 In: British Journal of Clinical Pharmacology. 84, p. 18-24 7 p.

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot Valérie et al. Jan 2018 In: Nature Genetics. 50, p. 26-41 16 p.

Efficient selective screening for heart failure in elderly men and women from the community: A diagnostic individual participant data meta-analysis

Kievit RF, Gohar A, Hoes AW, Bots ML, van Riet EES, van Mourik Y, Bertens LCM, Boonman-de Winter Leandra Jm, den Ruijter HM, Rutten FH, 2018 In: European Journal of Preventive Cardiology. 25, p. 437-446 10 p.

All Research Output (723)

Fellowship and Awards

Over the years Michiel Bots was involved in national and international collaborations that were successful in obtaining grants proposal from profit (pharmaceutical industry) and non profit organisations (ZonMw, Netherlands Heart Foundation, European Union, Dutch Kideny Foundation, CVON-HF).