dr. A.N. (Niels) Bovenschen Associate Professor

Department of Pathology

Contact

nbovensc@umcutrecht.nl

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

Niels Bovenschen studied Medical Biology at the Free University in Amsterdam. After obtaining his PhD degree in 2003 at Sanquin Research at CLB Amsterdam, he worked as a postdoc in Leiden (TNO, Gaubius Laboratory). In 2004, he moved to the department of Pathology at the University Medical Center Utrecht (UMCU). In 2006, he has received a prestigious personal VENI grant Netherlands from the Netherlands Organization for Scientific Research (NWO) for his work on the serine protease components (i.e. granzymes) in the cytolytic granules of cytotoxic lymphocytes. In 2009 he became an independent group leader (assistant professor) at the department of Pathology (UMCU). In 2012, he was appointed as Associate Professor at the same department. His research group now focuses on the role of granzymes in eliminating tumor cells and virus-infected cells, and the role of extracellular granzymes during inflammation. These aims fit within the UMCU focus area Immunity & Infection. He is in charge of Pathology Research Laboratory and the Laboratory of Translational Immunology core facility Proteins. He coordinates (bio)medical educational programs at the Utrecht University.

Side Activities

Chairman: Scientific board of Pediatric Brain Cancer Foundation Koppie-AU

Academic Editor: PLoS ONE

Editorial Board Member: Front. Cell. Dev. Biol.

Research Output

Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma

Vermeulen JF, van Hecke W, Adriaansen Elisabeth J M, Jansen MD, Bouma Rianne G., Villacorta Hidalgo José, Fisch Paul, Broekhuizen R., Spliet WGM, Kool Marcel, Bovenschen AN 2018 In: Oncoimmunology. 7, p. e1398877

Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus

Kok HM, van den Hoogen LL, van Roon JAG, Adriaansen Elisabeth J M, Fritsch RDE, Nguyen TQ, Goldschmeding R, Radstake TRDJ, Bovenschen AN 1 Dec 2017 In: Rheumatology (Oxford, England). 56, p. 2129-2134 6 p.

Oncogenic role of cytomegalovirus in medulloblastoma?

Hortal Alejandro M., Vermeulen JF, van Hecke W, Bovenschen AN 1 Nov 2017 In: Cancer Letters. 408, p. 55-59 5 p.

Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis

Kinashi H, Falke LL, Nguyen TQ, Bovenschen AN, Aten Jan, Leask Andrew, Ito Yasuhiko, Goldschmeding R Oct 2017 In: Kidney international. 92, p. 850-863 14 p.

Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis

Engelen-Lee Jooyeon, Blokhuis AM, Spliet WGM, Pasterkamp RJ, Aronica E, Demmers Jeroen A A, Broekhuizen R., Nardo Giovanni, Bovenschen AN, van den Berg LH 3 Apr 2017 In: Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 18, p. 210-220 11 p.

A novel proinflammatory role for granzyme A

Van Eck Jacqueline A., Shan Liling, Meeldijk Jan, Hack CE, Bovenschen AN 23 Feb 2017 In: Cell death & disease. 8

Granzymes A and K differentially potentiate LPS-induced cytokine response

Wensink Annette C, Kok HM, Meeldijk Jan, Fermie J, Froelich Christopher J, Hack CE, Bovenschen AN 2 Dec 2016 In: Cell death discovery. 2

Rapid hepatic clearance of full length CCN-2/CTGF: a putative role for LRP1-mediated endocytosis

Gerritsen KGF, Bovenschen AN, Nguyen TQ, Sprengers D, Koeners MPM, van Koppen AN, Joles JA, Goldschmeding R, Kok R J Dec 2016 In: Journal of Cell Communication and Signaling. 10, p. 295-303 9 p.

Biological responses of human solid tumor cells to X-ray irradiation within a 1.5-Tesla magnetic field generated by a magnetic resonance imaging–linear accelerator

Wang Li, Hoogcarspel SJ, Wen Zhifei, van Vulpen M, Molkentine David P., Kok Jan, Lin Steven H., Broekhuizen R., Ang Kie Kian, Bovenschen AN, Raaymakers BW, Frank Steven J. 1 Oct 2016 In: Bioelectromagnetics. 37, p. 471-480 10 p.

No evidence for human cytomegalovirus infection in pediatric medulloblastomas

Vermeulen JF, van Hecke W, Jansen Mieke K, Spliet WGM, Broekhuizen R., Bovenschen AN 12 Aug 2016 In: Neuro-Oncology. 18, p. 1461-1462