dr. A.N. (Niels) Bovenschen Associate Professor

Department of Pathology

Contact

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

Niels Bovenschen studied Medical Biology at the Free University in Amsterdam. After obtaining his PhD degree in 2003 at Sanquin Research at CLB Amsterdam, he worked as a postdoc in Leiden (TNO, Gaubius Laboratory). In 2004, he moved to the department of Pathology at the University Medical Center Utrecht (UMCU). In 2006, he has received a prestigious personal VENI grant Netherlands from the Netherlands Organization for Scientific Research (NWO) for his work on the serine protease components (i.e. granzymes) in the cytolytic granules of cytotoxic lymphocytes. In 2009 he became an independent group leader (assistant professor) at the department of Pathology (UMCU). In 2012, he was appointed as Associate Professor at the same department. His research group now focuses on the role of granzymes in eliminating tumor cells and virus-infected cells, and the role of extracellular granzymes during inflammation. These aims fit within the UMCU focus area Immunity & Infection. He is in charge of Pathology Research Laboratory and the Laboratory of Translational Immunology core facility Proteins. He coordinates (bio)medical educational programs at the Utrecht University.

Side Activities

Chairman: Scientific board of Pediatric Brain Cancer Foundation Koppie-AU

Academic Editor: PLoS ONE

Editorial Board Member: Front. Cell. Dev. Biol.

Research Output

Increased intra-articular granzyme M may trigger local IFN-λ1/IL-29 response in rheumatoid arthritis

Shan L, van den Hoogen LL, Meeldijk J., Kok HM, Jongeneel Lieneke H., Boes ML, Wenink MH, Hack C.E., Radstake TRDJ, van Roon J., Bovenschen AN 24 May 2019 In: Clinical and Experimental Rheumatology.

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

Bengsch Bertram, Ohtani Takuya, Khan Omar, Setty Manu, Manne Sasikanth, O'Brien Shaun, Gherardini Pier Federico, Herati Ramin Sedaghat, Huang Alexander C., Chang Kyong Mi, Newell Evan W., Bovenschen Niels, Pe'er Dana, Albelda Steven M., Wherry E. John 15 May 2018 In: Immunity. 48, p. 1029-1045.e5

Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns

Bengsch Bertram, Ohtani Takuya, Herati Ramin Sedaghat, Bovenschen Niels, Chang Kyong Mi, Wherry E. John Feb 2018 In: Journal of Immunological Methods. 453, p. 3-10 8 p.

Development and Validation of a Multiplex Non-HLA Antibody Assay for the Screening of Kidney Transplant Recipients

Kamburova Elena G., Kardol-Hoefnagel Tineke, Wisse Bram W., Joosten Irma, Allebes Wil A., van der Meer Arnold, Hilbrands Luuk B., Baas Marije C., Spierings Eric, Hack Cornelis E., van Reekum Franka E., van Zuilen Arjan D., Verhaar Marianne C., Bots Michiel L., Drop Adriaan C.A.D., Plaisier Loes, Meeldijk Jan, Bovenschen Niels, Seelen Marc A.J., Sanders Jan Stephan, Hepkema Bouke G., Lambeck Annechien J.A., Bungener Laura B., Roozendaal Caroline, Tilanus Marcel G.J., Voorter Christina E., Wieten Lotte, van Duijnhoven Elly M., Gelens Mariëlle A.C.J., Christiaans Maarten H.L., van Ittersum Frans J., Nurmohamed Shaikh A., Lardy Neubury M., Swelsen Wendy, van der Pant Karlijn A.M.I., van der Weerd Neelke C., Ten Berge Ineke J.M., Bemelman Frederike J., van der Boog Paul J.M., de Fijter Johan W., Betjes Michiel G.H., Heidt Sebastiaan, Roelen Dave L., Claas Frans H., Otten Henny G. 1 Jan 2018 In: Frontiers in Immunology. 9

Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma

Vermeulen Jeroen F., Van Hecke Wim, Adriaansen Elisabeth J M, Jansen Mieke K., Bouma Rianne G., Villacorta Hidalgo José, Fisch Paul, Broekhuizen Roel, Spliet Wim G.M., Kool Marcel, Bovenschen Niels 2018 In: OncoImmunology. 7, p. e1398877

Oncogenic role of cytomegalovirus in medulloblastoma?

Hortal Alejandro M., Vermeulen Jeroen F., Van Hecke Wim, Bovenschen Niels 1 Nov 2017 In: Cancer Letters. 408, p. 55-59 5 p.

Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus

Kok Helena M., van den Hoogen Lucas L., van Roon Joel A.G., Adriaansen Elisabeth J M, Fritsch-Stork Ruth D.E., Nguyen Tri Q., Goldschmeding Roel, Radstake Timothy R.D.J., Bovenschen Niels 5 Sep 2017 In: Rheumatology (Oxford, England). 56, p. 2129-2134 6 p.

Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis

Engelen-Lee Jooyeon, Blokhuis Anna M., Spliet Wim G.M., Pasterkamp R. Jeroen, Aronica Eleonora, Demmers Jeroen A A, Broekhuizen Roel, Nardo Giovanni, Bovenschen Niels, Van Den Berg Leonard H. 3 Apr 2017 In: Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 18, p. 210-220 11 p.

A novel proinflammatory role for granzyme A

Van Eck Jacqueline A., Shan Liling, Meeldijk Jan, Hack C. Erik, Bovenschen Niels 23 Feb 2017 In: Cell death & disease. 8

Granzymes A and K differentially potentiate LPS-induced cytokine response

Wensink Annette C, Kok Helena M, Meeldijk Jan, Fermie Job, Froelich Christopher J, Hack C Erik, Bovenschen Niels 2 Dec 2016 In: Cell death discovery. 2

All Research Output (75)

Fellowship and Awards

2017: Teaching Fellow Utrecht University

2015: Project grant Pediatric Brain Cancer Foundation Koppie-AU.

2013: Project grant Pediatric Brain Cancer Foundation Koppie-AU.

2012: Infection & Immunity Center Utrecht seeding project grant.

2009: Dutch Cancer Society (KWF) project grant.

2008: UMCU/DLA Research project grant.

2006: NWO/ZonMw VENI grant (Netherlands Organization for Scientific Research).