dr. A.N. (Niels) Bovenschen

Associate Professor

  • Department of Pathology

dr. A.N. (Niels) Bovenschen


Niels Bovenschen studied Medical Biology at the Free University in Amsterdam. After obtaining his PhD in 2003 at Sanquin Research at CLB Amsterdam, he worked as a postdoc in Leiden (TNO, Gaubius Laboratory). In 2004, he moved to the department of Pathology at the University Medical Center Utrecht (UMC Utrecht). In 2006, he received a prestigious VENI grant from the Netherlands Organization for Scientific Research (NWO) for his work on serine proteases (i.e. granzymes) in the cytolytic granules of cytotoxic lymphocytes. In 2009 he became group leader (Assistant Professor) at the department of Pathology (UMC Utrecht). In 2012, he was appointed as Associate Professor at the same department. His research group now focuses on the effector immune response in eliminating tumor cells and virus-infected cells. These aims fit within the UMC Utrecht focus areas Immunity & Infection and Cancer. He is in charge of the UMC Utrecht Pathology Research Laboratory and head of the Laboratory of Translational Immunology core facility Proteins. In 2017, Niels Bovenschen was appointed as Senior Fellow of Utrecht University. His mission is to engage undergraduate students in science by creating synergy between education and scientific research already at the early undergraduate level. He is examiner and coordinator of several (bio)medical educational programs at the faculty of Medicine, Utrecht University. In 2019, Niels Bovenschen won the Outstanding Teacher Award of Utrecht University.

Side Activities

  • Member KNAW Comenius network

    Academic Editor: PLoS ONE

    Editorial Board Member: Front. Cell. Dev. Biol.

Fellowship and Awards

  • 2019: Outstanding Teacher Award. Docent van het jaar. Utrecht University

    2018: NWO Comenius Teaching Fellow grant

    2018: Lecturer of the year. Docent van het jaar. Faculty of Medicine, Utrecht University

    2017: Teaching Fellow Utrecht University

    2015: Project grant Pediatric Brain Cancer Foundation Koppie-AU.

    2013: Project grant Pediatric Brain Cancer Foundation Koppie-AU.

    2012: Infection & Immunity Center Utrecht seeding project grant.

    2009: Dutch Cancer Society (KWF) project grant.

    2008: UMCU/DLA Research project grant.

    2006: NWO/ZonMw VENI grant (Netherlands Organization for Scientific Research).

Research Output (78)

Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes

Janiszewski Tomasz, Kołt Sonia, Kaiserman Dion, Snipas Scott J., Li Shuang, Kulbacka Julita, Saczko Jolanta, Bovenschen Niels, Salvesen Guy, Drąg Marcin, Bird Phillip I., Kasperkiewicz Paulina 10 jul 2020, In: The Journal of biological chemistry. 295 , p. 9567-9582 16 p.

Modulation of Inflammation by Extracellular Granzyme A

van Daalen Kim R., Reijneveld Josephine F., Bovenschen Niels 19 mei 2020, In: Frontiers in Immunology. 11

Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner

Shan Liling, Li Shuang, Meeldijk Jan, Blijenberg Bernadet, Hendriks Astrid, van Boxtel Karlijn J.W.M., van den Berg Sara P.H., Groves Ian J., Potts Martin, Svrlanska Adriana, Stamminger Thomas, Wills Mark R., Bovenschen Niels 1 apr 2020, In: PLoS Pathogens. 16

How a four-year-old boy connects healthcare, biomedical research and undergraduate education

Drost Rijkent H., Dictus Wim J.A.G., Prakken Berent J., Bovenschen Niels 1 sep 2019, In: Nature Biotechnology. 37 , p. 1092-1095 4 p.

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

Bengsch Bertram, Ohtani Takuya, Khan Omar, Setty Manu, Manne Sasikanth, O'Brien Shaun, Gherardini Pier Federico, Herati Ramin Sedaghat, Huang Alexander C., Chang Kyong Mi, Newell Evan W., Bovenschen Niels, Pe'er Dana, Albelda Steven M., Wherry E. John 15 mei 2018, In: Immunity. 48 , p. 1029-1045.e5

Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns

Bengsch Bertram, Ohtani Takuya, Herati Ramin Sedaghat, Bovenschen Niels, Chang Kyong Mi, Wherry E. John feb 2018, In: Journal of Immunological Methods. 453 , p. 3-10 8 p.

Development and Validation of a Multiplex Non-HLA Antibody Assay for the Screening of Kidney Transplant Recipients

Kamburova Elena G., Kardol-Hoefnagel Tineke, Wisse Bram W., Joosten Irma, Allebes Wil A., van der Meer Arnold, Hilbrands Luuk B., Baas Marije C., Spierings Eric, Hack Cornelis E., van Reekum Franka E., van Zuilen Arjan D., Verhaar Marianne C., Bots Michiel L., Drop Adriaan C.A.D., Plaisier Loes, Meeldijk Jan, Bovenschen Niels, Seelen Marc A.J., Sanders Jan Stephan, Hepkema Bouke G., Lambeck Annechien J.A., Bungener Laura B., Roozendaal Caroline, Tilanus Marcel G.J., Voorter Christina E., Wieten Lotte, van Duijnhoven Elly M., Gelens Mariëlle A.C.J., Christiaans Maarten H.L., van Ittersum Frans J., Nurmohamed Shaikh A., Lardy Neubury M., Swelsen Wendy, van der Pant Karlijn A.M.I., van der Weerd Neelke C., Ten Berge Ineke J.M., Bemelman Frederike J., van der Boog Paul J.M., de Fijter Johan W., Betjes Michiel G.H., Heidt Sebastiaan, Roelen Dave L., Claas Frans H., Otten Henny G. 1 jan 2018, In: Frontiers in Immunology. 9

Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma

Vermeulen Jeroen F., Van Hecke Wim, Adriaansen Elisabeth J M, Jansen Mieke K., Bouma Rianne G., Villacorta Hidalgo José, Fisch Paul, Broekhuizen Roel, Spliet Wim G.M., Kool Marcel, Bovenschen Niels 2018, In: OncoImmunology. 7 , p. e1398877

Oncogenic role of cytomegalovirus in medulloblastoma?

Hortal Alejandro M., Vermeulen Jeroen F., Van Hecke Wim, Bovenschen Niels 1 nov 2017, In: Cancer Letters. 408 , p. 55-59 5 p.

Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus

Kok Helena M., van den Hoogen Lucas L., van Roon Joel A.G., Adriaansen Elisabeth J M, Fritsch-Stork Ruth D.E., Nguyen Tri Q., Goldschmeding Roel, Radstake Timothy R.D.J., Bovenschen Niels 5 sep 2017, In: Rheumatology (Oxford, England). 56 , p. 2129-2134 6 p.

All Research Output (78)