dr. A.N. (Niels) Bovenschen Associate Professor

Department of Pathology

Contact

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

Niels Bovenschen studied Medical Biology at the Free University in Amsterdam. After obtaining his PhD in 2003 at Sanquin Research at CLB Amsterdam, he worked as a postdoc in Leiden (TNO, Gaubius Laboratory). In 2004, he moved to the department of Pathology at the University Medical Center Utrecht (UMC Utrecht). In 2006, he received a prestigious VENI grant from the Netherlands Organization for Scientific Research (NWO) for his work on serine proteases (i.e. granzymes) in the cytolytic granules of cytotoxic lymphocytes. In 2009 he became group leader (Assistant Professor) at the department of Pathology (UMC Utrecht). In 2012, he was appointed as Associate Professor at the same department. His research group now focuses on the effector immune response in eliminating tumor cells and virus-infected cells. These aims fit within the UMC Utrecht focus areas Immunity & Infection and Cancer. He is in charge of the UMC Utrecht Pathology Research Laboratory and head of the Laboratory of Translational Immunology core facility Proteins. In 2017, Niels Bovenschen was appointed as Senior Fellow of Utrecht University. His mission is to engage undergraduate students in science by creating synergy between education and scientific research already at the early undergraduate level. He is examiner and coordinator of several (bio)medical educational programs at the faculty of Medicine, Utrecht University. In 2019, Niels Bovenschen won the Outstanding Teacher Award of Utrecht University.

Side Activities

Member KNAW Comenius network

Academic Editor: PLoS ONE

Editorial Board Member: Front. Cell. Dev. Biol.

Research Output

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

Bengsch Bertram, Ohtani Takuya, Khan Omar, Setty Manu, Manne Sasikanth, O'Brien Shaun, Gherardini Pier Federico, Herati Ramin Sedaghat, Huang Alexander C., Chang Kyong Mi, Newell Evan W., Bovenschen Niels, Pe'er Dana, Albelda Steven M., Wherry E. John 15 May 2018 In: Immunity. 48, p. 1029-1045.e5

Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis

Engelen-Lee Jooyeon, Blokhuis Anna M., Spliet Wim G.M., Pasterkamp R. Jeroen, Aronica Eleonora, Demmers Jeroen A A, Broekhuizen Roel, Nardo Giovanni, Bovenschen Niels, Van Den Berg Leonard H. 3 Apr 2017 In: Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 18, p. 210-220 11 p.

Rapid hepatic clearance of full length CCN-2/CTGF: a putative role for LRP1-mediated endocytosis

Gerritsen K G F, Bovenschen N, Nguyen T Q, Sprengers D, Koeners M P, van Koppen A N, Joles J A, Goldschmeding R, Kok R J Dec 2016 In: Journal of Cell Communication and Signaling. 10, p. 295-303 9 p.

Biological responses of human solid tumor cells to X-ray irradiation within a 1.5-Tesla magnetic field generated by a magnetic resonance imaging–linear accelerator

Wang Li, Hoogcarspel Stan Jelle, Wen Zhifei, van Vulpen Marco, Molkentine David P., Kok Jan, Lin Steven H., Broekhuizen Roel, Ang Kie Kian, Bovenschen Niels, Raaymakers Bas W., Frank Steven J. 1 Oct 2016 In: Bioelectromagnetics. 37, p. 471-480 10 p.

No evidence for human cytomegalovirus infection in pediatric medulloblastomas

Vermeulen Jeroen F, van Hecke Wim, Jansen Mieke K, Spliet Wim G M, Broekhuizen Roel, Bovenschen Niels 12 Aug 2016 In: Neuro-Oncology. 18, p. 1461-1462

Granzyme M and K release in human experimental endotoxemia

Wensink Annette C., Wiewel Maryse A., Jongeneel Lieneke H., Boes Marianne, van der Poll Tom, Hack C. Erik, Bovenschen Niels Jul 2016 In: Immunobiology. 221, p. 773–777

Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors

van Kempen Pauline M W , Noorlag Rob, Swartz Justin E., Bovenschen Niels, Braunius Weibel W., Vermeulen Jeroen F., van Cann Ellen M. , Grolman Wilko, Willems Stefan M. 1 May 2016 In: Cancer Immunology, Immunotherapy. 65, p. 575-585 11 p.

Reduced serpinB9-mediated caspase-1 inhibition can contribute to autoinflammatory disease

Van Der Burgh Robert, Meeldijk Jan, Jongeneel Lieneke, Frenkel Joost, Bovenschen Niels, Van Gijn Mariëlle, Boes Marianne 12 Apr 2016 In: Oncotarget. 7, p. 19265-19271 7 p.

Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting

Meyer Saskia, Nederend Maaike, Jansen J H Marco, Reiding Karli R, Jacobino Shamir R, Meeldijk Jan, Bovenschen Niels, Wuhrer Manfred, Valerius Thomas, Ubink Ruud, Boross Peter, Rouwendal Gerard, Leusen Jeanette H W 2 Jan 2016 In: mAbs. 8, p. 87-98 12 p.

Pediatric Primitive Neuroectodermal Tumors of the Central Nervous System Differentially Express Granzyme Inhibitors

Vermeulen Jeroen F, van Hecke Wim, Spliet Wim G M, Villacorta Hidalgo José, Fisch Paul, Broekhuizen Roel, Bovenschen Niels 2016 In: PLoS ONE [E]. 11

All Research Output (48)

Fellowship and Awards

2019: Outstanding Teacher Award. Docent van het jaar. Utrecht University

2018: NWO Comenius Teaching Fellow grant

2018: Lecturer of the year. Docent van het jaar. Faculty of Medicine, Utrecht University

2017: Teaching Fellow Utrecht University

2015: Project grant Pediatric Brain Cancer Foundation Koppie-AU.

2013: Project grant Pediatric Brain Cancer Foundation Koppie-AU.

2012: Infection & Immunity Center Utrecht seeding project grant.

2009: Dutch Cancer Society (KWF) project grant.

2008: UMCU/DLA Research project grant.

2006: NWO/ZonMw VENI grant (Netherlands Organization for Scientific Research).