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prof. dr. K.P.J. (Kees) Braun

prof. dr. K.P.J. (Kees) Braun

Full Professor
prof. dr. K.P.J. (Kees) Braun
  • Neurologen

Research Programs

Brain

Biography

Biography

Kees Braun obtained his Medical Degree at Utrecht University in January 1992. He specialized in Neurology (registered in 2000) and Paediatric Neurology (registered in 2002) in the UMC Utrecht. In 2000 he obtained his PhD degree on a thesis entitled “Magnetic Resonance Spectroscopy in Hydrocephalus. He was appointed as staff neurologist in 2000 and paediatric neurologist in 2002. Since 2011 he is head of Paediatric Neurology/Neurosurgery.  In May 2012 he was appointed as a full professor of Paediatric Neurology.

His clinical and scientific areas of expertise are: refractory paediatric epilepsy, epilepsy surgery,  imaging in epilepsy, and childhood arteriopathic stroke, in particular moyamoya treatment.

He coordinates epilepsy research in the  UMCU Brain center. The epilepsy research projects he is personally involved in  focus on the effects of focal epilepsy on the brain in animal models and patients (structural and functional integrity and network analysis); seizure- and cognitive outcome after paediatric epilepsy surgery; postoperative antiepileptic drug withdrawal; ESES treatment; stress and epilepsy; and epileptic focus detection in surgical candidates.

Kees Braun currently is president of the Dutch Society of Paediatric Neurology and of the organizing committee of the 2016 world congress of child neurology (ICNC) in Amsterdam. He is member of the European Task Force for Epilepsy Surgery in Children (U-Task), the European Network for Epilepsy Research (ENER), and work-package leader of the EU-funded E-PILEPSY project.

Research line

Refractory epilepsy

Most recent key publications

1: Boshuisen K, Arzimanoglou A, Cross JH, Uiterwaal CS, Polster T, van Nieuwenhuizen O, Braun KP; for the TimeToStop study Group. Timing of antiepileptic drug withdrawal and long-term seizure outcome after paediatric epilepsy surgery (TimeToStop): a retrospective observational study. Lancet Neurol 2012:11:784-791
2: Van Campen JS, Jansen FE, Pet MA, Otte WM, Hillegers MH, Joels M, Braun KP. Relation between stress-precipitated seizures and the stress response in childhood epilepsy. Brain 2015;138:2234-2248
3: Lamberink HJ, Boshuisen K, van Rijen PC, Gosselaar PH, Braun KP. Changing profiles of pediatric epilepsy surgery candidates over time: a nationwide single-center experience from 1990 to 2011. Epilepsia 215;56:717-725
4: Boshuisen K, van Schooneveld MM, Uiterwaal CS, Cross JH, Harrison S, Polster T, Daehn M, Djimjadi S, Yalnizoglu D, Turanli G, Sassen R, Hoppe C, Kuczaty S, Barba C, Kahane P, Schubert-Bast S, Reuner G, Bast T, Strobl K, Mayer H, de Saint-Martin A, Seegmuller C, Laurent A, Arzimanoglou A, Braun KP, for the TimeToStop cognitive outcome study group. Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery. Ann Neurol 2015;78:104-114
5: Braun KPJ, Bulder MMM, Chabrier S, Kirkham FJ, Uiterwaal CSP, Tardieu M, Sebire G. Longitudinal vascular imaging in 79 children with ischemic stroke and unilateral intracranial arteriopathy. Brain 2009;132:544-557

Side Activities

As mentioned in the Biography.

Fellowship and Awards

1: Recipient of the first “Patrick Hanlo Award”, March 17 2009
2: Personal investment grant for epilepsy research by the Dutch National Epilepsy Fund
3: Recipient of the “Gerlach Cerfontaine Fellowship” of the Catharijne Foundation, UMCU, 1998-2000, for the PhD project “Magnetic Resonance Spectroscopy in Hydrocephalus”
4: Recipient of several research grants from e.g. the Dutch Epilepsy Fund, Johanna Children’s Fund, and Wilhelmina Research Fund.

Research Output (237)

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse A, van Huffelen Alexander C, van Klink Nicole E C, Benders Manon J N L, de Vries Linda S, Leijten Frans S S, Jansen Floor E, Braun Kees P J, Zijlmans Maeike 16 apr 2021, In: Clinical Neurophysiology. 132 , p. 1452-1461 10 p.

Alcohol and Brain Development in Adolescents and Young Adults:A Systematic Review of the Literature and Advisory Report of the Health Council of the Netherlands

de Goede Janette, van der Mark-Reeuwijk Kerstin G, Braun Kees P, le Cessie Saskia, Durston Sarah, Engels Rutger C M E, Goudriaan Anna E, Moons Karel G M, Vollebergh Wilma A M, de Vries Taco J, Wiers Reinout W, Oosterlaan Jaap 2 feb 2021, In: Advances in nutrition (Bethesda, Md.). 12 , p. 1379-1410 32 p.

Can we use intraoperative high-frequency oscillations to guide tumor-related epilepsy surgery?

van Klink Nicole E C, Zweiphenning Willemiek J E M, Ferrier Cyrille H, Gosselaar Peter H, Miller Kai J, Aronica Eleonora, Braun Kees P J, Zijlmans Maeike 2021, In: Epilepsia. 62 , p. 997-1004 8 p.

Corticosteroids versus clobazam in epileptic encephalopathy with ESES:a European multicentre randomised controlled clinical trial (RESCUE ESES*)

van den Munckhof Bart, Arzimanoglou Alexis, Perucca Emilio, van Teeseling Heleen C, Leijten Frans S S, Braun Kees P J, Jansen Floor E, 23 nov 2020, In: Trials. 21 , p. 1-11

A Functional Magnetic Resonance Imaging Approach for Language Laterality Assessment in Young Children

Charbonnier Lisette, Raemaekers Mathijs A H, Cornelisse Philippe A, Verwoert Maxime, Braun Kees P J, Ramsey Nick F, Vansteensel Mariska J 17 nov 2020, In: Frontiers in Pediatrics. 8 , p. 1-14

The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery:from group-level to patient-level analysis

Demuru Matteo, Kalitzin Stiliyan, Zweiphenning Willemiek, van Blooijs Dorien, van’t Klooster Maryse, Van Eijsden Pieter, Leijten Frans, Zijlmans Maeike, Braun Kees, Ferrier Cyrille, Gebbink Tineke, Gosselaar Peter, Huiskamp Geertjan, van Klink Nicole, Ophorst Janine, van Rijen Peter, van der Salm Sandra, Winter Anouk Velders de, 4 sep 2020, In: Scientific Reports. 10

Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis:a retrospective multicentre cohort study

Lamberink Herm J., Otte Willem M., Blümcke Ingmar, Braun Kees PJ, Aichholzer Martin, Amorim Isabel, Aparicio Javier, Aronica Eleonora, Arzimanoglou Alexis, Barba Carmen, Beck Jürgen, Becker Albert, Beckervordersandforth Jan C., Bien Christian G., Bodi Istvan, Braun Kees PJ, Catenoix Helene, Chassoux Francine, Chipaux Mathilde, Cloppenborg Thomas, Coras Roland, Cross J. Helen, De Palma Luca, De Tisi Jane, Deleo Francesco, Devaux Bertrand, Di Gennaro Giancarlo, Dorfmüller Georg, Duncan John S., Elger Christian, Ernst Katharina, Esposito Vincenzo, Feucht Martha, Gadze Zeljka Petelin, Garbelli Rita, Geleijns Karin, Gil-Nagel Antonio, Grote Alexander, Grunwald Thomas, Guerrini Renzo, Hamer Hajo, Honavar Mrinalini, Jacques Thomas S., Jakovcevic Antonia, Kalina Adam, Jansen Floor, Leijten Frans, van Rijen Peter, Spliet Wim GM, Mühlebner Angelika, , , sep 2020, In: The Lancet Neurology. 19 , p. 748-757 10 p.

Sleep slow wave homeostasis and cognitive functioning in children with electrical status epilepticus in sleep

van den Munckhof Bart, Gefferie Silvano R, van Noort Suus A M, van Teeseling Heleen C, Schijvens Mischa P, Smit William, Teunissen Nico W, Plate Joost D J, Huiskamp Geert Jan M, Leijten Frans S S, Braun Kees P J, Jansen Floor E, Bölsterli Bigna K 6 mei 2020, In: Sleep. 43 , p. 1-9

High frequency oscillations relate to cognitive improvement after epilepsy surgery in children

Sun Dongqing, van 't Klooster Maryse A., van Schooneveld Monique M.J., Zweiphenning Willemiek J.E.M., van Klink Nicole E.C., Ferrier Cyrille H., Gosselaar Peter H., Braun Kees P.J., Zijlmans Maeike 1 mei 2020, In: Clinical Neurophysiology. 131 , p. 1134-1141 8 p.

The resolution revolution:Comparing spikes and high frequency oscillations in high-density and standard intra-operative electrocorticography of the same patient

Zweiphenning Willemiek J E M, van Diessen Eric, Aarnoutse Erik J, Leijten Frans S S, van Rijen Peter C, Braun Kees P J, Zijlmans Maeike 2 mrt 2020, In: Clinical Neurophysiology. 131 , p. 1040-1043 4 p.

All research output

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