dr. L.A.A. (Lodewijk) Brosens
Associate Professor
- Department of Pathology
Contact
Biography
2015-present: Associate professor of pathology, gastrointestinal and endocrine pathology, UMC Utrecht.
2014-2015: Post-doctoral research fellow department of pathology Johns Hopkins Hospital, Baltimore
2013: Pathologist, gastrointestinal pathology, Academic Medical Center Amsterdam
2008-2013: Pathology residency
2008: PhD, Gastrointestinal polyposis syndromes, clinical and molecular aspects of Familial Adenomatous Polyposis en Juvenile Polyposis, Utrecht University
2006: M.D. University of Amsterdam
2004: MSc. Biomedical Science, Vrije Universiteit, Amsterdam
2003-2004: Research fellow Departments of Pathology and Gastroenterology, Johns Hopkins Hospital, Baltimore
Side Activities
Member of the scientific committee Dutch Pancreatic Cancer Group (DPCG)
Member of scientific council pancreas parel (nationwide biobank)
Member of scientific committee LWH Foundation
Member of Dutch working group on Barrett's esophagus
WHO Classification of Tumours 5Th Edition - Tumours of the Digestive System, co-author
Associate Editor BMC Cancer
Pathologist RadboudUMC (0,2 fte) gastrointestinal and pancreatic pathology
Visiting professor of pathology, University of Verona, Italy
Fellowship and Awards
2018: University of Verona Internationalization Program Stipend
2014: MLDS Career Development Grant
2013: UICC Yamagiwa-Yoshida Memorial international study grant
2013: Nijbakker-Morra Stichting Stipend
Research Output (102)
Impact of nationwide enhanced implementation of best practices in pancreatic cancer care (PACAP-1):a multicenter stepped-wedge cluster randomized controlled trial
Mackay T M, Smits F J, Latenstein A E J, Bogte A, Bonsing B A, Bos H, Bosscha K, Brosens L A A, Hol L, Busch O R C, Creemers G J, Curvers W L, den Dulk M, van Dieren S, van Driel L M J W, Festen S, van Geenen E J M, van der Geest L G, de Groot D J A, de Groot J W B, Haj Mohammad N, Haberkorn B C M, Haver J T, van der Harst E, Hemmink G J M, de Hingh I H, Hoge C, Homs M Y V, van Huijgevoort N C, Jacobs M A J M, Kerver E D, Liem M S L, Los M, Lubbinge H, Luelmo S A C, de Meijer V E, Mekenkamp L, Molenaar I Q, van Oijen M G H, Patijn G A, Quispel R, van Rijssen L B, Römkens T E H, van Santvoort H C, Schreinemakers J M J, Schut H, Seerden T, Verdonk R C, Wessels F J, van Werkhoven C H, 16 apr 2020, In: Trials. 21 18 p.
Optimal timing for prediction of pathologic complete response to neoadjuvant chemoradiotherapy with diffusion-weighted MRI in patients with esophageal cancer
Borggreve Alicia S, Heethuis Sophie E, Boekhoff Mick R, Goense Lucas, van Rossum Peter S N, Brosens Lodewijk A A, van Lier Astrid L H M W, van Hillegersberg Richard, Lagendijk Jan J W, Mook Stella, Ruurda Jelle P, Meijer Gert J 1 apr 2020, In: European Radiology. 30 , p. 1896-1907 12 p.
Assessment of ARX expression, a novel biomarker for metastatic risk in pancreatic neuroendocrine tumors, in endoscopic ultrasound fine-needle aspiration
Hackeng Wenzel M., Morsink Folkert H.M., Moons Leon M.G., Heaphy Christopher M., Offerhaus G. Johan A., Dreijerink Koen M.A., Brosens Lodewijk A.A. apr 2020, In: Diagnostic cytopathology. 48 , p. 308-315 8 p.
Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups With Differing Risks of Liver Metastases
Pea Antonio, Yu Jun, Marchionni Luigi, Noe Michael, Luchini Claudio, Pulvirenti Alessandra, de Wilde Roeland F, Brosens Lodewijk A, Rezaee Neda, Javed Ammar, Gobbo Stefano, Regi Paolo, Salvia Roberto, Bassi Claudio, He Jin, Weiss Matthew J, Cameron John L, Offerhaus G Johan A, Hruban Ralph H, Lawlor Rita T, Scarpa Aldo, Heaphy Christopher M, Wood Laura D, Wolfgang Christopher L 1 mrt 2020, In: Annals of Surgery. 271 , p. 566-573 8 p.
Pancreatic cancer organoids recapitulate disease and allow personalized drug screening
Driehuis Else, Van Hoeck Arne, Moore Kat, Kolders Sigrid, Francies Hayley E., Gulersonmez M. Can, Stigter Edwin C.A., Burgering Boudewijn, Geurts Veerle, Gracanin Ana, Bounova Gergana, Morsink Folkert H., Vries Robert, Boj Sylvia, Van Es Johan, Offerhaus G. Johan A., Kranenburg Onno, Garnett Mathew J., Wessels Lodewyk, Cuppen Edwin, Brosens Lodewijk A.A., Clevers Hans 9 dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116 , p. 26580-26590 11 p.
Publisher Correction:Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors (Nature Medicine, (2019), 25, 8, (1260-1265), 10.1038/s41591-019-0493-4)
Cejas Paloma, Drier Yotam, Dreijerink Koen M A, Brosens Lodewijk A A, Deshpande Vikram, Epstein Charles B, Conemans Elfi B, Morsink Folkert H M, Graham Mindy K, Valk Gerlof D, Vriens Menno R, Castillo Carlos Fernandez-Del, Ferrone Cristina R, Adar Tomer, Bowden Michaela, Whitton Holly J, Da Silva Annacarolina, Font-Tello Alba, Long Henry W, Gaskell Elizabeth, Shoresh Noam, Heaphy Christopher M, Sicinska Ewa, Kulke Matthew H, Chung Daniel C, Bernstein Bradley E, Shivdasani Ramesh A 9 sep 2019, In: Nature Medicine. 25 , p. 1627 1 p.
Liquid Biopsy as Surrogate for Tissue for Molecular Profiling in Pancreatic Cancer:A Meta-Analysis Towards Precision Medicine
Luchini Claudio, Veronese Nicola, Nottegar Alessia, Cappelletti Vera, Daidone Maria G, Smith Lee, Parris Christopher, Brosens Lodewijk A A, Caruso Maria G, Cheng Liang, Wolfgang Christopher L, Wood Laura D, Milella Michele, Salvia Roberto, Scarpa Aldo 10 aug 2019, In: Cancers. 11
Adherence to pre-set benchmark quality criteria to qualify as expert assessor of dysplasia in Barrett's esophagus biopsies - towards digital review of Barrett's esophagus
van der Wel M J, Klaver E, Duits L C, Pouw R E, Seldenrijk C A, Offerhaus Gja, Visser M, Ten Kate Fjw, Biermann K, Brosens Laa, Doukas M, Huysentruyt C, Karrenbeld A, Kats-Ugurlu G, van der Laan J S, van Lijnschoten G, Moll Fcp, Ooms Ahag, Tijssen J G, Bergman Jjghm, Meijer S L aug 2019, In: United European Gastroenterology Journal. 7 , p. 889-896 8 p.
Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors
Cejas Paloma, Drier Yotam, Dreijerink Koen M.A., Brosens Lodewijk A.A., Deshpande Vikram, Epstein Charles B., Conemans Elfi B., Morsink Folkert H.M., Graham Mindy K., Valk Gerlof D., Vriens Menno R., Castillo Carlos Fernandez del, Ferrone Cristina R., Adar Tomer, Bowden Michaela, Whitton Holly J., Da Silva Annacarolina, Font-Tello Alba, Long Henry W., Gaskell Elizabeth, Shoresh Noam, Heaphy Christopher M., Sicinska Ewa, Kulke Matthew H., Chung Daniel C., Bernstein Bradley E., Shivdasani Ramesh A. aug 2019, In: Nature Medicine. 25 , p. 1260-1265 6 p.
Well-differentiated Pancreatic Neuroendocrine Tumor in a Patient With Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM)
Noë Michaël, Hackeng Wenzel M, de Leng Wendy W J, Vergeer Menno, Vleggaar Frank P, Morsink Folkert H M, Wood Laura D, Hruban Ralph H, Offerhaus G Johan A, Brosens Lodewijk A A 28 jun 2019, In: American Journal of Surgical Pathology. 43 , p. 1297-1302 6 p.