dr. L.A.A. (Lodewijk) Brosens
Associate Professor
- Department of Pathology
Contact
Biography
2015-present: Associate professor of pathology, gastrointestinal and endocrine pathology, UMC Utrecht.
2014-2015: Post-doctoral research fellow department of pathology Johns Hopkins Hospital, Baltimore
2013: Pathologist, gastrointestinal pathology, Academic Medical Center Amsterdam
2008-2013: Pathology residency
2008: PhD, Gastrointestinal polyposis syndromes, clinical and molecular aspects of Familial Adenomatous Polyposis en Juvenile Polyposis, Utrecht University
2006: M.D. University of Amsterdam
2004: MSc. Biomedical Science, Vrije Universiteit, Amsterdam
2003-2004: Research fellow Departments of Pathology and Gastroenterology, Johns Hopkins Hospital, Baltimore
Side Activities
Member of the scientific committee Dutch Pancreatic Cancer Group (DPCG)
Member of scientific council pancreas parel (nationwide biobank)
Member of scientific committee LWH Foundation
Member of Dutch working group on Barrett's esophagus
WHO Classification of Tumours 5Th Edition - Tumours of the Digestive System, co-author
Associate Editor BMC Cancer
Pathologist RadboudUMC (0,2 fte) gastrointestinal and pancreatic pathology
Visiting professor of pathology, University of Verona, Italy
Fellowship and Awards
2018: University of Verona Internationalization Program Stipend
2014: MLDS Career Development Grant
2013: UICC Yamagiwa-Yoshida Memorial international study grant
2013: Nijbakker-Morra Stichting Stipend
Research Output (108)
Gastric Epithelial Polyps:When to Ponder, When to Panic
Vos Shoko, van der Post Rachel S, Brosens Lodewijk A A sep 2020, In: Surgical Pathology Clinics. 13 , p. 431-452 22 p.
The CARDIA-trial protocol:a multinational, prospective, randomized, clinical trial comparing transthoracic esophagectomy with transhiatal extended gastrectomy in adenocarcinoma of the gastroesophageal junction (GEJ) type II
Leers Jessica M, Knepper Laura, van der Veen Arjen, Schröder Wolfgang, Fuchs Hans, Schiller Petra, Hellmich Martin, Zettelmeyer Ulrike, Brosens Lodewijk A A, Quaas Alexander, Ruurda Jelle P, van Hillegersberg Richard, Bruns Christiane J 20 aug 2020, In: BMC Cancer. 20 , p. 781
Genomic characterization of malignant progression in neoplastic pancreatic cysts
Noë Michaël, Niknafs Noushin, Fischer Catherine G, Hackeng Wenzel M, Beleva Guthrie Violeta, Hosoda Waki, Debeljak Marija, Papp Eniko, Adleff Vilmos, White James R, Luchini Claudio, Pea Antonio, Scarpa Aldo, Butturini Giovanni, Zamboni Giuseppe, Castelli Paola, Hong Seung-Mo, Yachida Shinichi, Hiraoka Nobuyoshi, Gill Anthony J, Samra Jaswinder S, Offerhaus G Johan A, Hoorens Anne, Verheij Joanne, Jansen Casper, Adsay N Volkan, Jiang Wei, Winter Jordan, Albores-Saavedra Jorge, Terris Benoit, Thompson Elizabeth D, Roberts Nicholas J, Hruban Ralph H, Karchin Rachel, Scharpf Robert B, Brosens Lodewijk A A, Velculescu Victor E, Wood Laura D 14 aug 2020, In: Nature Communications. 11 12 p.
Diagnostic accuracy of contrast-enhanced diffusion-weighted MRI for liver metastases of pancreatic cancer:towards adequate staging and follow-up of pancreatic cancer - DIA-PANC study: study protocol for an international, multicenter, diagnostic trial
Litjens G, Rivière D M, van Geenen E J M, Radema S A, Brosens L A A, Prokop M, van Laarhoven C J H M, Hermans J J 10 aug 2020, In: BMC Cancer. 20 8 p.
Medullary Pancreatic Carcinoma Due to Somatic POLE Mutation:A Distinctive Pancreatic Carcinoma With Marked Long-Term Survival
Kryklyva Valentyna, Ter Linden Esther, Kroeze Leonie I, de Voer Richarda M, van der Kolk B Marion, Stommel Martijn W J, Hermans John J, Luchini Claudio, Wood Laura D, Hruban Ralph H, Nagtegaal Iris D, Ligtenberg Marjolijn J L, Brosens Lodewijk A A aug 2020, In: Pancreas. 49 , p. 999-1003 5 p.
The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors:report of 2 cases
Kranendonk Mariëtte E G, Hackeng Wenzel M, Offerhaus G Johan A, Morsink Folkert H M, Jonges Geertruida N, Groenewegen Gerard, Krijtenburg Pieter-Jaap, Klümpen Heinz-Josef, de Leng Wendy W J, Looijenga Leendert H J, Brosens Lodewijk A A 25 jul 2020, In: Diagnostic Pathology. 15 8 p.
Impact of nationwide enhanced implementation of best practices in pancreatic cancer care (PACAP-1):a multicenter stepped-wedge cluster randomized controlled trial
Mackay T M, Smits F J, Latenstein A E J, Bogte A, Bonsing B A, Bos H, Bosscha K, Brosens L A A, Hol L, Busch O R C, Creemers G J, Curvers W L, den Dulk M, van Dieren S, van Driel L M J W, Festen S, van Geenen E J M, van der Geest L G, de Groot D J A, de Groot J W B, Haj Mohammad N, Haberkorn B C M, Haver J T, van der Harst E, Hemmink G J M, de Hingh I H, Hoge C, Homs M Y V, van Huijgevoort N C, Jacobs M A J M, Kerver E D, Liem M S L, Los M, Lubbinge H, Luelmo S A C, de Meijer V E, Mekenkamp L, Molenaar I Q, van Oijen M G H, Patijn G A, Quispel R, van Rijssen L B, Römkens T E H, van Santvoort H C, Schreinemakers J M J, Schut H, Seerden T, Verdonk R C, Wessels F J, van Werkhoven C H, 16 apr 2020, In: Trials. 21 18 p.
Optimal timing for prediction of pathologic complete response to neoadjuvant chemoradiotherapy with diffusion-weighted MRI in patients with esophageal cancer
Borggreve Alicia S, Heethuis Sophie E, Boekhoff Mick R, Goense Lucas, van Rossum Peter S N, Brosens Lodewijk A A, van Lier Astrid L H M W, van Hillegersberg Richard, Lagendijk Jan J W, Mook Stella, Ruurda Jelle P, Meijer Gert J 1 apr 2020, In: European Radiology. 30 , p. 1896-1907 12 p.
Assessment of ARX expression, a novel biomarker for metastatic risk in pancreatic neuroendocrine tumors, in endoscopic ultrasound fine-needle aspiration
Hackeng Wenzel M., Morsink Folkert H.M., Moons Leon M.G., Heaphy Christopher M., Offerhaus G. Johan A., Dreijerink Koen M.A., Brosens Lodewijk A.A. apr 2020, In: Diagnostic cytopathology. 48 , p. 308-315 8 p.
Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups With Differing Risks of Liver Metastases
Pea Antonio, Yu Jun, Marchionni Luigi, Noe Michael, Luchini Claudio, Pulvirenti Alessandra, de Wilde Roeland F, Brosens Lodewijk A, Rezaee Neda, Javed Ammar, Gobbo Stefano, Regi Paolo, Salvia Roberto, Bassi Claudio, He Jin, Weiss Matthew J, Cameron John L, Offerhaus G Johan A, Hruban Ralph H, Lawlor Rita T, Scarpa Aldo, Heaphy Christopher M, Wood Laura D, Wolfgang Christopher L 1 mrt 2020, In: Annals of Surgery. 271 , p. 566-573 8 p.