dr. L.A.A. (Lodewijk) Brosens Associate Professor

Department of Pathology

Contact

lbrosens@umcutrecht.nl

Research programs

Cancer

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

2015-present: Associate professor of pathology, gastrointestinal and endocrine pathology, UMC Utrecht.

2014-2015: Post-doctoral research fellow department of pathology Johns Hopkins Hospital, Baltimore

2013: Pathologist, gastrointestinal pathology, Academic Medical Center Amsterdam

2008-2013: Pathology residency

2008: PhD, Gastrointestinal polyposis syndromes, clinical and molecular aspects of Familial Adenomatous Polyposis en Juvenile Polyposis, Utrecht University

2006: M.D. University of Amsterdam

2004: MSc. Biomedical Science, Vrije Universiteit, Amsterdam

2003-2004: Research fellow Departments of Pathology and Gastroenterology, Johns Hopkins Hospital, Baltimore

Side Activities

Member of the scientific committee Dutch Pancreatic Cancer Group (DPCG)

Member of scientific council pancreas parel (nationwide biobank)

Member of scientific committee LWH Foundation

Member of Dutch working group on Barrett's esophagus

WHO Classification of Tumours 5Th Edition - Tumours of the Digestive System, co-author

Associate Editor BMC Cancer

Pathologist RadboudUMC (0,2 fte) gastrointestinal and pancreatic pathology

Visiting professor of pathology, University of Verona, Italy

Research Output

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial

van Hilst Jony, de Rooij Thijs, Bosscha Koop, Brinkman David J., van Dieren Susan, Dijkgraaf Marcel G., Gerhards Michael F., de Hingh Ignace H., Karsten Tom M., Lips Daniel J., Luyer Misha D., Busch Olivier R., Festen Sebastiaan, Besselink Marc G., Marsman Hendrik A., Van Gulik Thomas M., Wicherts Dennis A., Eshuis Wietse J., Stibbe Luna A., Nieveen van Dijkum Els JM, Van Hooft Janine E., Fockens Paul, Van Laarhoven Hanneke W., Wilmink Johanna W., Van de Vijver Marcel J., Bijlsma Maarten F., Verheij Joanne, Nio C. Yung, Van Lienden Krijn P., Van Tienhoven Geertjan, Schoorlemmer Annuska, Creemers Geert Jan, Van Eijck Casper HJ, Groot Koerkamp Bas, Bruno Marco J., Eskens Ferry, Nuyttens Joost J., Pek Chulja, Van der Schelling George P., Seerden Tom C., De Groot Jan W., Brosens Lodewijk A., Te Riele Wouter, Van Santvoort Hjalmar C., Molenaar I. Quintus, Haj Mohammad Nadia, Van Leeuwen Maarten S., Daamen Lois, Walma Marieke, Rombouts Steffi, 23 Jan 2019 In: The Lancet Gastroenterology and Hepatology. 4, p. 199-207 9 p.

DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment

Conemans Elfi B, Lodewijk Lutske, Moelans Cathy M, Offerhaus G Johan A, Pieterman Carolina R C, Morsink Folkert H, Dekkers Olaf M, de Herder Wouter W, Hermus Ad R, van der Horst-Schrivers Anouk N A, Drent Madeleine L, Bisschop Peter H, Havekes Bas, Brosens Lodewijk A A, Dreijerink Koen M A, Borel Rinkes Inne H M, Timmers H Th Marc, Valk Gerlof D, Vriens Menno R 14 Jun 2018 In: European Journal of Endocrinology. 179, p. 153-160 8 p.

Whole-exome sequencing of duodenal neuroendocrine tumors in patients with neurofibromatosis type 1

Noë Michaël, Pea Antonio, Luchini Claudio, Felsenstein Matthäus, Barbi Stefano, Bhaijee Feriyl, Yonescu Raluca, Ning Yi, Adsay N. Volkan, Zamboni Giuseppe, Lawlor Rita T., Scarpa Aldo, Offerhaus G. Johan A., Brosens Lodewijk A.A., Hruban Ralph H., Roberts Nicholas J., Wood Laura D. 30 May 2018 In: Modern Pathology. p. 1-7 7 p.

Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology

Noë Michaël, Rezaee Neda, Asrani Kaushal, Skaro Michael, Groot Vincent P., Wu Pei Hsun, Olson Matthew T., Hong Seung Mo, Kim Sung Joo, Weiss Matthew J., Wolfgang Christopher L., Makary Martin A., He Jin, Cameron John L., Wirtz Denis, Roberts Nicholas J., Offerhaus G. Johan A., Brosens Lodewijk A.A., Wood Laura D., Hruban Ralph H. 20 Apr 2018 In: American Journal of Pathology. 188, p. 1530-1535 6 p.

The Dutch Pancreas Biobank within the Parelsnoer Institute: A nationwide Biobank of pancreatic and periampullary diseases

Strijker Marin, Gerritsen Arja, Van Hilst Jony, Bijlsma Maarten F., Bonsing Bert A., Brosens Lodewijk A., Bruno Marco J., Van Dam Ronald M., Dijk Frederike, Van Eijck Casper H., Farina Sarasqueta Arantza, Fockens Paul, Gerhards Michael F., Groot Koerkamp Bas, Van Der Harst Erwin, De Hingh Ignace H., Van Hooft Jeanin E., Huysentruyt Clément J., Kazemier Geert, Klaase Joost M., Van Laarhoven Cornelis J., Van Laarhoven Hanneke W., Liem Mike S., De Meijer Vincent E., Van Rijssen L. Bengt, Van Santvoort Hjalmar C., Suker Mustafa, Verhagen Judith H., Verheij Joanne, Verspaget Hein W., Wennink Roos A., Wilmink Johanna W., Molenaar I. Quintus, Boermeester Marja A., Busch Olivier R., Besselink Marc G. 1 Apr 2018 In: Pancreas. 47, p. 495-501 7 p.

IPMNs with co-occurring invasive cancers: Neighbours but not always relatives

Felsenstein Matthäus, Noë Michaël, Masica David L., Hosoda Waki, Chianchiano Peter, Fischer Catherine G., Lionheart Gemma, Brosens Lodewijk A.A., Pea Antonio, Yu Jun, Gemenetzis Georgios, Groot Vincent P., Makary Martin A., He Jin, Weiss Matthew J., Cameron John L., Wolfgang Christopher L., Hruban Ralph H., Roberts Nicholas J., Karchin Rachel, Goggins Michael G., Wood Laura D. Apr 2018 In: Gut. 67, p. 1561-1563

Pathology and genetics of hereditary colorectal cancer

Ma Huiying, Brosens Lodewijk A.A., Offerhaus G. Johan A., Giardiello Francis M., de Leng Wendy W.J., Montgomery Elizabeth A. 1 Jan 2018 In: Pathology. 50, p. 49-59 11 p.

Dilemmas for the pathologist in the oncologic assessment of pancreatoduodenectomy specimens: An overview of different grossing approaches and the relevance of the histopathological characteristics in the oncologic assessment of pancreatoduodenectomy specimens

Soer Eline, Brosens Lodewijk, van de Vijver Marc, Dijk Frederike, van Velthuysen Marie Louise, Farina-Sarasqueta Arantza, Morreau Hans, Offerhaus Johan, Koens Lianne, Verheij Joanne 2018 In: Virchows Archives. 472, p. 533-543 11 p.

Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis

Cruz-Correa Marcia, Hylind Linda M., Marrero Jessica Hernandez, Zahurak Marianna L., Murray-Stewart Tracy, Casero Robert A., Montgomery Elizabeth A., Iacobuzio-Donahue Christine, Brosens Lodewijk A., Offerhaus G. Johan, Umar Asad, Rodriguez Luz M., Giardiello Francis M. 2018 In: Gastroenterology. 155, p. 668-673 6 p.

Targeted next-generation sequencing of commonly mutated genes in esophageal adenocarcinoma patients with long-term survival

Visser E, Franken Ingrid A, Brosens L A A, de Leng W W J, Strengman E, Offerhaus J A, Ruurda J P, van Hillegersberg R 1 Sep 2017 In: Diseases of the Esophagus. 30, p. 1-8 8 p.

All Research Output (49)

Fellowship and Awards

2018: University of Verona Internationalization Program Stipend

2014: MLDS Career Development Grant

2013: UICC Yamagiwa-Yoshida Memorial international study grant

2013: Nijbakker-Morra Stichting Stipend