dr. L.A.A. (Lodewijk) Brosens Associate Professor

Department of Pathology

Contact

lbrosens@umcutrecht.nl

Research programs

Cancer

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

2015-present: Associate professor of pathology, gastrointestinal and endocrine pathology, UMC Utrecht.

2014-2015: Post-doctoral research fellow department of pathology Johns Hopkins Hospital, Baltimore

2013: Pathologist, gastrointestinal pathology, Academic Medical Center Amsterdam

2008-2013: Pathology residency

2008: PhD, Gastrointestinal polyposis syndromes, clinical and molecular aspects of Familial Adenomatous Polyposis en Juvenile Polyposis, Utrecht University

2006: M.D. University of Amsterdam

2004: MSc. Biomedical Science, Vrije Universiteit, Amsterdam

2003-2004: Research fellow Departments of Pathology and Gastroenterology, Johns Hopkins Hospital, Baltimore

Side Activities

Member of the scientific committee Dutch Pancreatic Cancer Group (DPCG)

Member of scientific council pancreas parel (nationwide biobank)

Member of scientific committee LWH Foundation

Member of Dutch working group on Barrett's esophagus

WHO Classification of Tumours 5Th Edition - Tumours of the Digestive System, co-author

Associate Editor BMC Cancer

Pathologist RadboudUMC (0,2 fte) gastrointestinal and pancreatic pathology

Visiting professor of pathology, University of Verona, Italy

Research Output

Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review

Kryklyva Valentyna, Haj Mohammad Nadia, Morsink Folkert H M, Ligtenberg Marjolijn J L, Offerhaus G Johan A, Nagtegaal Iris D, de Leng Wendy W J, Brosens Lodewijk A A 19 Apr 2019 In: Cancer Biology & Therapy. p. 1-7 7 p.

Why is Pancreatic Cancer so Deadly?: The Pathologist's View

Hruban Ralph H, Gaida Matthias M, Thompson Elizabeth, Hong Seung-Mo, Nöe Michaël, Brosens Lodewijk A A, Jongepier Martine, Offerhaus G Johan A, Wood Laura D 5 Mar 2019 In: Journal of Pathology.

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial

van Hilst Jony, de Rooij Thijs, Bosscha Koop, Brinkman David J., van Dieren Susan, Dijkgraaf Marcel G., Gerhards Michael F., de Hingh Ignace H., Karsten Tom M., Lips Daniel J., Luyer Misha D., Busch Olivier R., Festen Sebastiaan, Besselink Marc G., Marsman Hendrik A., Van Gulik Thomas M., Wicherts Dennis A., Eshuis Wietse J., Stibbe Luna A., Nieveen van Dijkum Els JM, Van Hooft Janine E., Fockens Paul, Van Laarhoven Hanneke W., Wilmink Johanna W., Van de Vijver Marcel J., Bijlsma Maarten F., Verheij Joanne, Nio C. Yung, Van Lienden Krijn P., Van Tienhoven Geertjan, Schoorlemmer Annuska, Creemers Geert Jan, Van Eijck Casper HJ, Groot Koerkamp Bas, Bruno Marco J., Eskens Ferry, Nuyttens Joost J., Pek Chulja, Van der Schelling George P., Seerden Tom C., De Groot Jan W., Brosens Lodewijk A., Te Riele Wouter, Van Santvoort Hjalmar C., Molenaar I. Quintus, Haj Mohammad Nadia, Van Leeuwen Maarten S., Daamen Lois, Walma Marieke, Rombouts Steffi, 23 Jan 2019 In: The Lancet Gastroenterology and Hepatology. 4, p. 199-207 9 p.

Pseudomyxoma Peritonei after a Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm with Colloid Carcinoma in Lynch Syndrome

Hackeng Wenzel M., De Guerre Livia E.V.M., Kuypers Karel C., Snoek Alexander M., Morsink Folkert H., Offerhaus G. Johan A., Brosens Lodewijk A.A. 1 Jan 2019 In: Pancreas. 48, p. 135-138 4 p.

PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications

Luchini Claudio, Cros Jerome, Pea Antonio, Pilati Camilla, Veronese Nicola, Rusev Borislav, Capelli Paola, Mafficini Andrea, Nottegar Alessia, Brosens Lodewijk A.A., Noë Michaël, Offerhaus G. Johan A., Chianchiano Peter, Riva Giulio, Piccoli Paola, Parolini Claudia, Malleo Giuseppe, Lawlor Rita T., Corbo Vincenzo, Sperandio Nicola, Barbareschi Mattia, Fassan Matteo, Cheng Liang, Wood Laura D., Scarpa Aldo 18 Jul 2018 In: Human Pathology. 81, p. 157-165 9 p.

DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment

Conemans Elfi B, Lodewijk Lutske, Moelans Cathy M, Offerhaus G Johan A, Pieterman Carolina R C, Morsink Folkert H, Dekkers Olaf M, de Herder Wouter W, Hermus Ad R, van der Horst-Schrivers Anouk N A, Drent Madeleine L, Bisschop Peter H, Havekes Bas, Brosens Lodewijk A A, Dreijerink Koen M A, Borel Rinkes Inne H M, Timmers H Th Marc, Valk Gerlof D, Vriens Menno R 14 Jun 2018 In: European Journal of Endocrinology. 179, p. 153-160 8 p.

Whole-exome sequencing of duodenal neuroendocrine tumors in patients with neurofibromatosis type 1

Noë Michaël, Pea Antonio, Luchini Claudio, Felsenstein Matthäus, Barbi Stefano, Bhaijee Feriyl, Yonescu Raluca, Ning Yi, Adsay N. Volkan, Zamboni Giuseppe, Lawlor Rita T., Scarpa Aldo, Offerhaus G. Johan A., Brosens Lodewijk A.A., Hruban Ralph H., Roberts Nicholas J., Wood Laura D. 30 May 2018 In: Modern Pathology. p. 1-7 7 p.

Improved diagnostic stratification of digitised Barrett's oesophagus biopsies by p53 immunohistochemical staining

van der Wel Myrtle J., Duits Lucas C., Pouw Roos E., Seldenrijk Cornelis A., Offerhaus G. J.A., Visser Mike, ten Kate Fiebo J., Biermann Katharina, Brosens Lodewijk A.A., Doukas Michael, Huysentruyt Clement, Karrenbeld Arend, Kats-Ugurlu Gursah, van der Laan Jaap S., van Lijnschoten G. Ineke, Moll Freek C.P., Ooms Ariadne H.A.G., van der Valk Hans, Tijssen Jan G., Bergman Jacques J., Meijer Sybren L. 1 May 2018 In: Histopathology. 72, p. 1015-1023 9 p.

Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing

Spoto Clothaire P.E., Gullo Irene, Carneiro Fatima, Montgomery Elizabeth A., Brosens Lodewijk A.A. 1 May 2018 In: Seminars in Diagnostic Pathology. 35, p. 170-183 14 p.

Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology

Noë Michaël, Rezaee Neda, Asrani Kaushal, Skaro Michael, Groot Vincent P., Wu Pei Hsun, Olson Matthew T., Hong Seung Mo, Kim Sung Joo, Weiss Matthew J., Wolfgang Christopher L., Makary Martin A., He Jin, Cameron John L., Wirtz Denis, Roberts Nicholas J., Offerhaus G. Johan A., Brosens Lodewijk A.A., Wood Laura D., Hruban Ralph H. 20 Apr 2018 In: American Journal of Pathology. 188, p. 1530-1535 6 p.

All Research Output (73)

Fellowship and Awards

2018: University of Verona Internationalization Program Stipend

2014: MLDS Career Development Grant

2013: UICC Yamagiwa-Yoshida Memorial international study grant

2013: Nijbakker-Morra Stichting Stipend