dr. L.A.A. (Lodewijk) Brosens

Associate Professor - medical
dr. L.A.A. (Lodewijk) Brosens
  • Department of Pathology

Research Programs

Strategic Program Cancer



2015-present: Associate professor of pathology, gastrointestinal and endocrine pathology, UMC Utrecht.

2014-2015: Post-doctoral research fellow department of pathology Johns Hopkins Hospital, Baltimore

2013: Pathologist, gastrointestinal pathology, Academic Medical Center Amsterdam

2008-2013: Pathology residency

2008: PhD, Gastrointestinal polyposis syndromes, clinical and molecular aspects of Familial Adenomatous Polyposis en Juvenile Polyposis, Utrecht University

2006: M.D. University of Amsterdam

2004: MSc. Biomedical Science, Vrije Universiteit, Amsterdam

2003-2004: Research fellow Departments of Pathology and Gastroenterology, Johns Hopkins Hospital, Baltimore

Side Activities

Member of the scientific committee Dutch Pancreatic Cancer Group (DPCG)

Member of scientific council pancreas parel (nationwide biobank)

Member of scientific committee LWH Foundation

Member of Dutch working group on Barrett's esophagus

WHO Classification of Tumours 5Th Edition - Tumours of the Digestive System, co-author

WHO Classification of Tumours 5Th Edition - Endocrine and Neuroendocrine tumours Tumours, co-author

Associate Editor BMC Cancer

Pathologist RadboudUMC (0,2 fte) gastrointestinal and pancreatic pathology

Visiting professor of pathology, University of Verona, Italy

Associate Editor Cancer Biology & Therapy


Fellowship and Awards

2018: University of Verona Internationalization Program Stipend

2014: MLDS Career Development Grant

2013: UICC Yamagiwa-Yoshida Memorial international study grant

2013: Nijbakker-Morra Stichting Stipend

Research Output (134)

Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Pancreatic Cancer:Systematic Review and Still-Open Questions

Lawlor Rita T, Mattiolo Paola, Mafficini Andrea, Hong Seung-Mo, Piredda Maria L, Taormina Sergio V, Malleo Giuseppe, Marchegiani Giovanni, Pea Antonio, Salvia Roberto, Kryklyva Valentyna, Shin Jae Il, Brosens Lodewijk A, Milella Michele, Scarpa Aldo, Luchini Claudio 22 jun 2021, In: Cancers. 13 , p. 1-15

A Parathyroid-Gut Axis:Hypercalcemia and the Pathogenesis of Gastrinoma in Multiple Endocrine Neoplasia 1

Hackeng Wenzel M, Dreijerink Koen M A, Offerhaus G Johan A, Brosens Lodewijk A A 26 mrt 2021, In: Molecular Cancer Research. 19 , p. 946-949 4 p.

Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution

Busslinger Georg A, Weusten Bas L A, Bogte Auke, Begthel Harry, Brosens Lodewijk A A, Clevers Hans 9 mrt 2021, In: Cell Reports. 34 , p. 1-23

The Role of CT in Assessment of Extraregional Lymph Node Involvement in Pancreatic and Periampullary Cancer:A Diagnostic Accuracy Study

Tseng Dorine S J, Pranger Bobby K, van Leeuwen Maarten S, Pennings Jan Pieter, Brosens Lodewijk A, Mohammad Nadja Haj, de Meijer Vincent E, van Santvoort Hjalmar C, Erdmann Joris I, Molenaar I Quintus mrt 2021, In: Radiology. Imaging cancer. 3

Scoring of tumour response after neoadjuvant therapy in resected pancreatic cancer:systematic review

van Roessel S, Janssen B V, Soer E C, Fariña Sarasqueta A, Verbeke C S, Luchini C, Brosens L A A, Verheij J, Besselink M G feb 2021, In: British Journal of Surgery. 108 , p. 119-127 9 p.

Genome methylation accurately predicts neuroendocrine tumor origin - an online tool

Hackeng Wenzel M, Dreijerink Koen M A, de Leng Wendy W J, Morsink Folkert H, Valk Gerlof D, Vriens Menno R, Offerhaus G Johan A, Geisenberger Christoph, Brosens Lodewijk A A 22 dec 2020, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 27 , p. 1341-1350 10 p.

The management of neuroendocrine tumors of the lung in MEN1:results from the Dutch MEN1 Study Group

Van Den Broek Medard F M, De Laat Joanne M, Van Leeuwaarde Rachel S, Van De Ven Annenienke C, De Herder Wouter W, Dekkers Olaf M, Drent Madeleine L, Kerstens Michiel N, Bisschop Peter H, Havekes Bas, Hackeng Wenzel M, Brosens Lodewijk A A, Vriens Menno R, Buikhuisen Wieneke A, Valk Gerlof D 2 nov 2020, In: The Journal of clinical endocrinology and metabolism. 106 , p. e1014-e1027

Minimally Invasive Resection of Large Gastric Gastrointestinal Stromal Tumors

Gertsen Emma C, van Boxel Gijs I, Brosens Lodewijk A A, Ruurda Jelle P, van Hillegersberg Richard 25 sep 2020, In: Digestive Surgery. 37 , p. 441-446 6 p.

Gastric Epithelial Polyps:When to Ponder, When to Panic

Vos Shoko, van der Post Rachel S, Brosens Lodewijk A A sep 2020, In: Surgical Pathology Clinics. 13 , p. 431-452 22 p.

The CARDIA-trial protocol:a multinational, prospective, randomized, clinical trial comparing transthoracic esophagectomy with transhiatal extended gastrectomy in adenocarcinoma of the gastroesophageal junction (GEJ) type II

Leers Jessica M, Knepper Laura, van der Veen Arjen, Schröder Wolfgang, Fuchs Hans, Schiller Petra, Hellmich Martin, Zettelmeyer Ulrike, Brosens Lodewijk A A, Quaas Alexander, Ruurda Jelle P, van Hillegersberg Richard, Bruns Christiane J 20 aug 2020, In: BMC Cancer. 20 12 p.

All research output

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