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drs. R.M. (Rachel) Brouwer

Assistant Professor
  • Psychiatry

Research Programs

Brain

Biography

Biography

Rachel Brouwer obtained her PhD in the field of mathematics under supervision of Prof. J. van den Berg, at the Center of Mathematics and Computer Science in 2005. The title of her PhD was “Percolation, forest-fires and monomer-dimers, or the hunt for self-organized criticality”.

Since april 2006, she is working in the Department of Psychiatry of the University Medical Center Utrecht, were she is senior researcher on the BrainSCALE project, a longitudinal twin study into healthy development of brain and cognition during puberty, and the genetic and environmental components that influence this development. She is involved in the twin studies of the department, and in development of post-processing of MRI data and its statistical analysis.

Research lines

BrainSCALE project; a longitudinal twin-sibling study in adolescence into brain and cognition

ENIGMA-plasticity; through the ENIGMA consortium we investigate the genetics of brain plasticity measured through longitudinal MRI

Selected publications

Rachel M Brouwer, Matthew S Panizzon, David C Glahn, Derrek P Hibar, Xue Hua, Neda Jahanshad, Lucija Abramovic, Greig I de Zubicaray, Carol E Franz, Narelle K Hansell, Ian B Hickie, Marinka M G Koenis, Nicholas G Martin, Karen A Mather, Katie L McMahon, Hugo G Schnack, Lachlan T Strike, Suzanne C Swagerman, Anbupalam Thalamuthu, Wei Wen & 9 others, 2017, Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Human brain mapping DOI.

Bohlken, M. M., Brouwer, R. M., Mandl, R. C. W., Kahn, R. S. & Hulshoff Pol, H. E. (2016) Genetic Variation in Schizophrenia Liability is Shared With Intellectual Ability and Brain Structure. Schizophrenia Bulletin. 425p. 1167-1175

Brouwer, R. M., Hedman, A. M., van Haren, N. E. M., Schnack, H. G., Brans, R. G. H., Smit, D. J., Kahn, R. S., Boomsma, D. I. & Hulshoff Pol, H. E. (2014) Heritability of brain volume change and its relation to intelligence. Neuroimage. 100p. 676-683 8 p.

van Soelen IL, Brouwer RM, van Baal GC, Schnack HG, Peper JS, Chen L, Kahn RS, Boomsma DI, Pol HE (2013): Heritability of volumetric brain changes and height in children entering puberty. Hum Brain Map Mar;34(3):713-25.

 

Research Output (98)

The YOUth study:Rationale, design, and study procedures

Onland-Moret N. Charlotte, Buizer-Voskamp Jacobine E., Albers Maria E.W.A., Brouwer Rachel M., Buimer Elizabeth E.L., Hessels Roy S., de Heus Roel, Huijding Jorg, Junge Caroline M.M., Mandl René C.W., Pas Pascal, Vink Matthijs, van der Wal Juliëtte J.M., Hulshoff Pol Hilleke E., Kemner Chantal 7 okt 2020, In: Developmental Cognitive Neuroscience. 46 , p. 1-16

The YOUth cohort study:MRI protocol and test-retest reliability in adults

Buimer Elizabeth E.L., Pas Pascal, Brouwer Rachel M., Froeling Martijn, Hoogduin Hans, Leemans Alexander, Luijten Peter, van Nierop Bastiaan J., Raemaekers Mathijs, Schnack Hugo G., Teeuw Jalmar, Vink Matthijs, Visser Fredy, Hulshoff Pol Hilleke E., Mandl René C.W. okt 2020, In: Developmental Cognitive Neuroscience. 45 , p. 1-15

Changes in the intracranial volume from early adulthood to the sixth decade of life:A longitudinal study

Caspi Yaron, Brouwer Rachel M, Schnack Hugo G, van de Nieuwenhuijzen Marieke E, Cahn Wiepke, Kahn René S, Niessen Wiro J, van der Lugt Aad, Pol Hilleke Hulshoff 24 apr 2020, In: NeuroImage. 220 , p. 1-16

ENIGMA and global neuroscience:A decade of large-scale studies of the brain in health and disease across more than 40 countries

Thompson Paul M., Jahanshad Neda, Ching Christopher R.K., Salminen Lauren E., Thomopoulos Sophia I., Bright Joanna, Baune Bernhard T., Bertolín Sara, Bralten Janita, Bruin Willem B., Bülow Robin, Chen Jian, Chye Yann, Dannlowski Udo, de Kovel Carolien G.F., Donohoe Gary, Eyler Lisa T., Faraone Stephen V., Favre Pauline, Filippi Courtney A., Frodl Thomas, Garijo Daniel, Gil Yolanda, Grabe Hans J., Grasby Katrina L., Hajek Tomas, Han Laura K.M., Hatton Sean N., Hilbert Kevin, Ho Tiffany C., Holleran Laurena, Homuth Georg, Hosten Norbert, Houenou Josselin, Ivanov Iliyan, Jia Tianye, Kelly Sinead, Klein Marieke, Kwon Jun Soo, Laansma Max A., Leerssen Jeanne, Lueken Ulrike, Nunes Abraham, Neill Joseph O’, Opel Nils, Piras Fabrizio, Brouwer Rachel M., de Zwarte Sonja M.C., Hulshoff Pol Hilleke E., van Haren Neeltje E.M., 20 mrt 2020, In: Translational Psychiatry. 10

The genetic architecture of the human cerebral cortex

Grasby Katrina L, Jahanshad Neda, Painter Jodie N, Colodro-Conde Lucía, Bralten Janita, Hibar Derrek P, Lind Penelope A, Pizzagalli Fabrizio, Ching Christopher R K, McMahon Mary Agnes B, Shatokhina Natalia, Zsembik Leo C P, Thomopoulos Sophia I, Zhu Alyssa H, Strike Lachlan T, Agartz Ingrid, Alhusaini Saud, Almeida Marcio A A, Alnæs Dag, Amlien Inge K, Andersson Micael, Ard Tyler, Armstrong Nicola J, Ashley-Koch Allison, Atkins Joshua R, Bernard Manon, Brouwer Rachel M, Buimer Elizabeth E L, Bülow Robin, Bürger Christian, Cannon Dara M, Chakravarty Mallar, Chen Qiang, Cheung Joshua W, Couvy-Duchesne Baptiste, Dale Anders M, Dalvie Shareefa, de Araujo Tânia K, de Zubicaray Greig I, de Zwarte Sonja M C, Klein Marieke, van Haren Neeltje E M, Veldink Jan H, Ayesa-Arriola Rosa, Cahn Wiepke, Hillegers Manon H J, Hulshoff Pol Hilleke E, Kahn René S, Ophoff Roel A, Sommer Iris E, 20 mrt 2020, In: Science. 367

Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Sønderby Ida E., Gústafsson Ómar, Doan Nhat Trung, Hibar Derrek P., Martin-Brevet Sandra, Abdellaoui Abdel, Ames David, Amunts Katrin, Andersson Michael, Armstrong Nicola J., Bernard Manon, Blackburn Nicholas, Blangero John, Boomsma Dorret I., Bralten Janita, Brattbak Hans Richard, Brodaty Henry, Brouwer Rachel M., Bülow Robin, Calhoun Vince, Caspers Svenja, Cavalleri Gianpiero, Chen Chi Hua, Cichon Sven, Ciufolini Simone, Corvin Aiden, Crespo-Facorro Benedicto, Curran Joanne E., Dale Anders M., Dalvie Shareefa, Dazzan Paola, de Geus Eco J.C., de Zubicaray Greig I., de Zwarte Sonja M.C., Delanty Norman, den Braber Anouk, Desrivières Sylvane, Donohoe Gary, Draganski Bogdan, Ehrlich Stefan, Espeseth Thomas, Fisher Simon E., Franke Barbara, Frouin Vincent, Fukunaga Masaki, Gareau Thomas, Hillegers Manon H.J., Kahn Rene, Ophoff Roel, van Haren Neeltje E.M., 1 mrt 2020, In: Molecular Psychiatry. 25 , p. 584-602 19 p.

Structural methods in gray matter

Mandl René C.W., Schnack Hugo G., Brouwer Rachel M., Hulshoff Pol Hilleke E. 1 jan 2020, p. 3-26 24 p.

Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal Claudia L., Adams Hieab H.H., Hibar Derrek P., White Charles C., Knol Maria J., Stein Jason L., Scholz Markus, Sargurupremraj Muralidharan, Jahanshad Neda, Roshchupkin Gennady V., Smith Albert V., Bis Joshua C., Jian Xueqiu, Luciano Michelle, Hofer Edith, Teumer Alexander, van der Lee Sven J., Yang Jingyun, Yanek Lisa R., Lee Tom V., Li Shuo, Hu Yanhui, Koh Jia Yu, Eicher John D., Desrivières Sylvane, Arias-Vasquez Alejandro, Chauhan Ganesh, Athanasiu Lavinia, Rentería Miguel E., Kim Sungeun, Hoehn David, Armstrong Nicola J., Chen Qiang, Holmes Avram J., den Braber Anouk, Kloszewska Iwona, Andersson Micael, Abramovic Lucija, Bohlken Marc M., Klein Marieke, Boks Marco P., van Eijk Kristel R., Cahn Wiepke, Hulshoff Pol Hilleke E., Ikram M. Kamran, Brouwer Rachel M., Kahn René S., Ophoff Roel A., van Haren Neeltje E.M., Schmidt Reinhold, 1 nov 2019, In: Nature Genetics. 51 , p. 1624-1636 13 p.

Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition

van der Meer Dennis, Sønderby Ida E, Kaufmann Tobias, Walters G Bragi, Abdellaoui Abdel, Ames David, Amunts Katrin, Andersson Micael, Armstrong Nicola J, Bernard Manon, Blackburn Nicholas B, Blangero John, Boomsma Dorret I, Brodaty Henry, Brouwer Rachel M, Bülow Robin, Cahn Wiepke, Calhoun Vince D, Caspers Svenja, Cavalleri Gianpiero L, Ching Christopher R K, Cichon Sven, Ciufolini Simone, Corvin Aiden, Crespo-Facorro Benedicto, Curran Joanne E, Dalvie Shareefa, Dazzan Paola, de Geus Eco J C, de Zubicaray Greig I, de Zwarte Sonja M C, Delanty Norman, den Braber Anouk, Desrivieres Sylvane, Di Forti Marta, Doherty Joanne L, Donohoe Gary, Ehrlich Stefan, Eising Else, Espeseth Thomas, Fisher Simon E, Fladby Tormod, Frei Oleksandr, Frouin Vincent, Fukunaga Masaki, Gareau Thomas, Glahn David C, Hillegers Manon H J, Hulshoff Pol Hilleke E, Ophoff Roel A, 30 okt 2019, In: JAMA Psychiatry. 77 , p. 420-430 11 p.

Genetic and environmental influences on functional connectivity within and between canonical cortical resting-state networks throughout adolescent development in boys and girls

Teeuw Jalmar, Brouwer Rachel M, Guimarães João P O F T, Brandner Philip, Koenis Marinka M G, Swagerman Suzanne C, Verwoert Maxime, Boomsma Dorret I, Hulshoff Pol Hilleke E 3 aug 2019, In: NeuroImage. 202 16 p.

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