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dr. R.M. (Rachel) Brouwer Assistant Professor

  • Psychiatry


Research Programs


Rachel Brouwer obtained her PhD in the field of mathematics under supervision of Prof. J. van den Berg, at the Center of Mathematics and Computer Science in 2005. The title of her PhD was “Percolation, forest-fires and monomer-dimers, or the hunt for self-organized criticality”.

Since april 2006, she is working in the Department of Psychiatry of the University Medical Center Utrecht, were she is senior researcher on the BrainSCALE project, a longitudinal twin study into healthy development of brain and cognition during puberty, and the genetic and environmental components that influence this development. She is involved in the twin studies of the department, and in development of post-processing of MRI data and its statistical analysis.

Research lines

BrainSCALE project; a longitudinal twin-sibling study in adolescence into brain and cognition

ENIGMA-plasticity; through the ENIGMA consortium we investigate the genetics of brain plasticity measured through longitudinal MRI

Selected publications

Rachel M Brouwer, Matthew S Panizzon, David C Glahn, Derrek P Hibar, Xue Hua, Neda Jahanshad, Lucija Abramovic, Greig I de Zubicaray, Carol E Franz, Narelle K Hansell, Ian B Hickie, Marinka M G Koenis, Nicholas G Martin, Karen A Mather, Katie L McMahon, Hugo G Schnack, Lachlan T Strike, Suzanne C Swagerman, Anbupalam Thalamuthu, Wei Wen & 9 others, 2017, Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Human brain mapping DOI.

Bohlken, M. M., Brouwer, R. M., Mandl, R. C. W., Kahn, R. S. & Hulshoff Pol, H. E. (2016) Genetic Variation in Schizophrenia Liability is Shared With Intellectual Ability and Brain Structure. Schizophrenia Bulletin. 425p. 1167-1175

Brouwer, R. M., Hedman, A. M., van Haren, N. E. M., Schnack, H. G., Brans, R. G. H., Smit, D. J., Kahn, R. S., Boomsma, D. I. & Hulshoff Pol, H. E. (2014) Heritability of brain volume change and its relation to intelligence. Neuroimage. 100p. 676-683 8 p.

van Soelen IL, Brouwer RM, van Baal GC, Schnack HG, Peper JS, Chen L, Kahn RS, Boomsma DI, Pol HE (2013): Heritability of volumetric brain changes and height in children entering puberty. Hum Brain Map Mar;34(3):713-25.


Research Output (73)

Heritability of cerebral glutamate levels and their association with schizophrenia spectrum disorders:a <sup>1</sup> [H]-spectroscopy twin study

Legind Christian Stefan, Broberg Brian Villumsen, Mandl René Christiaan William, Brouwer Rachel, Anhøj Simon Jesper, Hilker Rikke, Jensen Maria Høj, McGuire Philip, Pol Hilleke Hulshoff, Fagerlund Birgitte, Rostrup Egill, Glenthøj Birte Yding 2018, In: Neuropsychopharmacology. 44 , p. 581-589 9 p.

XKR4 Gene Effects on Cerebellar Development Are Not Specific to ADHD

Shook Devon, Brouwer Rachel, de Zeeuw Patrick, Oranje Bob, Durston Sarah 12 dec 2017, In: Frontiers in Cellular Neuroscience [E]. 11

Novel genetic loci associated with hippocampal volume

Hibar Derrek P et al. 18 jan 2017, In: Nature Communications [E]. 8

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Adams Hieab H H et al. dec 2016, In: Nature Neuroscience. 19 , p. 1569-1582 14 p.

A study of genetic and environmental contributions to structural brain changes over time in twins concordant and discordant for bipolar disorder

Bootsman F., Brouwer R. M., Schnack H. G., Kemner S. M., Hillegers M. H J, Sarkisyan G., van der Schot A. C., Vonk R., Hulshoff Pol H. E., Nolen W. A., Kahn R. S., van Haren N. E M 1 aug 2016, In: Journal of Psychiatric Research. 79 , p. 116-124 9 p.

The association between hippocampal volume and life events in healthy twins

Bootsman Florian, Kemner Sanne M., Hillegers Manon H J, Brouwer Rachel M., Vonk Ronald, van der Schot Astrid C., Hulshoff Pol Hilleke E., Nolen Willem A., Kahn René S., van Haren Neeltje E M 1 aug 2016, In: Hippocampus. 26 , p. 1088-1095 8 p.

Peripheral immune abnormalities in two high-risk populations for bipolar disorder

Snijders G., Schiweck C., Brouwer Rachel, Mesman E., Grosse L., De Wit H., Nolen W. A., Drexhage H. A., Hillegers M. H. J. jul 2016, In: Bipolar Disorders. 18 , p. 175-175

Heritability of cortical thickness changes over time in twin pairs discordant for schizophrenia

Hedman Anna M., van Haren Neeltje E M, van Baal G. Caroline M, Brouwer Rachel M., Brans Rachel G H, Schnack Hugo G., Kahn René S., Hulshoff Pol Hilleke E. 1 jun 2016, In: Schizophrenia Research. 173 , p. 192-199 8 p.

Genetic Variation in Schizophrenia Liability is Shared With Intellectual Ability and Brain Structure

Bohlken Marc M, Brouwer Rachel M, Mandl René C W, Kahn René S, Hulshoff Pol Hilleke E 7 apr 2016, In: Schizophrenia Bulletin. 42 , p. 1167-1175

All Research Output (73)
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