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dr. H. (Hilgo) Bruining

Associate Professor - medical
dr. H. (Hilgo) Bruining
  • Psychiatry

Research Programs

Brain

Biography

Biography

Hilgo Bruining was trained as a pediatrician and a child and adolescent psychiatrist. He received his PhD in 2011 entitled "Genetic dissection of behavioral phenotypes". Since 2011 he is a researcher en member of clinical staff at the department of Psychiatry of the Brain Center Rudolf Magnus. He is the initiator and PI of the clinical and research care program focused on the diagnosis and treament of sensory processing abnormalities in neurodevelopmental disorders. The main focus of the program is to establish an EEG based descision support system to guide rational treatment development.  In addition, he collaborates on preclinical research programs to enhance translation of animal model findings to clinical studies and practice.

http://www.umcutrecht.nl/nl/Ziekenhuis/Afdelingen/Hersencentrum/Poliklinieken-en-verpleegafdelingen/Poliklinieken/Ontwikkelingsstoornissen-(polikliniek)/Zorgprogramma-Prikkelverwerking.   

Research line

Sensory Processing; Neurodevelopmental disorders; CNS inhibition;Autism Spectrum Disorder;Rational treatment development.

Most recent key publications

1: Behavioural disinhibition and antiepileptic treatment in childhood epilepsy: a retrospective cohort study. Diana C. van Tuijl, Rolf H.H. Groenwold, Chantal Vlaskamp, Jolien S. van Campen, Kees P.J. Braun, Floor E. Jansen,, U, Bruining H. Epilepsia Open, 2017.

2: van Campen S, Jansen FE, Kleinrensink, NJ, Joëls M, Braun KPJ, Bruining H. Sensory Modulation Disorders in Childhood Epilepsy. Journal of Neurodevelopmental Disorders, 2016.

3: Bruining H, Passtoors L, Goriounova N, et al. Paradoxical benzodiazepine response: a rationale for bumetanide in neurodevelopmental disorders? Pediatrics, 2015.

4: Bruining H, Matsui A, Oguro-Ando A, Kahn R, et al. Genetic mapping in mice reveals the involvement of Pcdh9 in long-term social and object recognition, and sensorimotor development. Biological Psychiatry, 2015.

5: Behavioral signatures related to genetic disorders in autism. Bruining H, Eijkemans MJ, Kas MJ, Curran SR, Vorstman JA, Bolton PF. Mol Autism, 2014.

Fellowship and Awards

Grants:

2017    Zon MW. TOP subsidy, 675kE, co PI.

2016    Dutch Brain Society. Sooner Better Treatment program, 300kE PI.

2015    ZonMW.  Rational Pharmacotherapy Program (GGG) program, 327kE PI.

2015    Stichting Michelle foundation. Research in Tuberous Sclerosis, 30kE PI.  

Awards:

2012    Annual research prize of the Dutch Association for Autism for best scientific contribution.

2012    EMBO short-term fellowship.

2011    Personal fellowship from the Dr. J.L. Dobberke Foundation for research at Osaka University.

Research Output (26)

Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex:An open-label pilot study

Van Andel Dorinde M., Sprengers Jan J., Oranje Bob, Scheepers Floortje E., Jansen Floor E., Bruining Hilgo 7 mei 2020, In: Molecular Autism. 11 14 p.

LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky Nikolaus, Almouzni Geneviève, Gorski Stanislaw A., Aerts Stein, Amit Ido, Bertero Michela G., Bock Christoph, Bredenoord Annelien L., Cavalli Giacomo, Chiocca Susanna, Clevers Hans, De Strooper Bart, Eggert Angelika, Ellenberg Jan, Fernández Xosé M., Figlerowicz Marek, Gasser Susan M., Hubner Norbert, Kjems Jørgen, Knoblich Jürgen A., Krabbe Grietje, Lichter Peter, Linnarsson Sten, Marine Jean Christophe, Marioni John, Marti-Renom Marc A., Netea Mihai G., Nickel Dörthe, Nollmann Marcelo, Novak Halina R., Parkinson Helen, Piccolo Stefano, Pinheiro Inês, Pombo Ana, Popp Christian, Reik Wolf, Roman-Roman Sergio, Rosenstiel Philip, Schultze Joachim L., Stegle Oliver, Tanay Amos, Testa Giuseppe, Thanos Dimitris, Theis Fabian J., Torres-Padilla Maria Elena, van Oudenaarden Alexander, Bruining Hilgo, Jongsma Karin R., Pasterkamp R. Jeroen, van Oudenaarden Alexander, 2020, In: Nature. 587 , p. 377-386 10 p.

Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice

Molenhuis Remco T., Bruining Hilgo, Brandt Myrna J.V., Van Soldt Petra E., Abu-Toamih Atamni Hanifa J., Burbach J. Peter H., Iraqi Fuad A., Mott Richard F., Kas Martien J.H. 13 dec 2018, In: Molecular Autism. 9

Loss of Cntnap2 Causes Axonal Excitability Deficits, Developmental Delay in Cortical Myelination, and Abnormal Stereotyped Motor Behavior

Scott Ricardo, Sánchez-Aguilera Alberto, van Elst Kim, Lim Lynette, Dehorter Nathalie, Bae Sung Eun, Bartolini Giorgia, Peles Elior, Kas Martien J H, Bruining Hilgo, Marín Oscar 28 dec 2017, In: Cerebral Cortex. 29 , p. 586-597 12 p.

Bumetanide as a candidate treatment for behavioral problems in tuberous sclerosis complex

Vlaskamp Chantal, Poil Simon Shlomo, Jansen Floor, Linkenkaer-Hansen Klaus, Durston Sarah, Oranje Bob, Bruining Hilgo 8 sep 2017, In: Frontiers in Neurology. 8

Het brein in ontwikkeling: translationele benaderingen in de kinderpsychiatrie

Bruining H, de Gaag R.J. 1 jun 2017, p. 73-90

Modelling Autistic Features in Mice Using Quantitative Genetic Approaches

Molenhuis Remco T, Bruining Hilgo, Kas Martien J 2017, p. 65-84 20 p.

Behavioral disinhibition and antiepileptic treatment in childhood epilepsy: A retrospective cohort study.

van Tuijl Diana, Groenwold RHH, Vlaskamp C, van Campen JS, Braun KPJ, Jansen FE, Bruining H 2017, In: Epilepsia Open. 2 , p. 59-66

Limited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice

Molenhuis Remco T, Bruining Hilgo, Remmelink Esther, de Visser Leonie, Loos Maarten, Burbach J Peter H, Kas Martien J H 2016, In: Journal of neurodevelopmental disorders. 8

Genetic mapping in mice reveals the involvement of Pcdh9 in long-term social and object recognition and sensorimotor development

Bruining Hilgo, Matsui Asuka, Oguro-Ando Asami, Kahn René S., Van'T Spijker Heleen M., Akkermans Guus, Stiedl Oliver, Van Engeland Herman, Koopmans Bastijn, Van Lith Hein A., Oppelaar Hugo, Tieland Liselotte, Nonkes Lourens J., Yagi Takeshi, Kaneko Ryosuke, Burbach J. Peter H, Yamamoto Nobuhiko, Kas Martien J. 1 okt 2015, In: Biological Psychiatry. 78 , p. 485-495 11 p.

All research output

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