prof. dr. J.C. (Hans) Clevers

Full Professor

  • Molecular Cancer Research
  • Hubrecht Institute

prof. dr. J.C. (Hans) Clevers


Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA. From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht and from 2012-2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). His research group is part of the Hubrecht institute.

He is Chevalier de la Legion d'Honneur since 2005 and Knight in the Order of the Netherlands Lion since 2012.

Side Activities

  • Honorary professorship:

    2002 –  Honorary professor at Changsha-Hunan, China



    Member European Molecular Biology Organisation (EMBO)

    Member of the Royal Netherlands Academy of Sciences

    Member of the International Society for Stem Cell Research (ISSCR)

    Member of the Scientific Advisory Board of ISREC, Swiss Institute for Experimental Cancer Research

    Member Scientific Committee of the Louis-Jeantet Foundation for Medicine

    Member of the American Association for Cancer Research (AACR)

    Member of the National Scientific Advisory Board NKI-AVL

    Member of the scientific advisory board of “de Anatomische Les”

    Member of the Academia Europaea

    Member of the Scientific Advisory Board of the MRC Clinical Sciences Centre

    Member of the American Academy of Arts and Sciences

    Member of the The Royal Holland Society of Sciences and Humanities

    Member of the Gairdner Foundation medical advisory board

    Foreign Associate of the US National Academy of Sciences

    Member of the Scientific advisory committee (SAC) of the Princess Máxima Center for Pediatric Oncology


    He is member of a several Editorial Boards, among them are the EMBO Journal, Gastroenterology, Cell and Genes & Development,Cell Stem Cell and the Annual Review of Cancer Biology

Fellowship and Awards

  • 2000     Catharijne-prize for medical science

    2001     Award from the European Society for Clinical Investigation

    2001     Spinoza-award

    2004     Louis-Jeantet Prize for Medicine

    2005     The Science and Society Prize

    2005     The French honor of “Chevalier de la Legion d'Honneur”

    2005     Katharine Berkan Judd Award

    2006     Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research

    2008     Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam)

    2008     Meyenburg Cancer Research Award

    2009     The Queen Wilhelmina Dutch Cancer Society Award

    2010     The United European Gastroenterology Federation (UEGF) Research Prize

    2011     The Ernst Jung Medical Award

    2011     Kolff prize

    2012     Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize

    2012     William Beaumont prize of the American Gastroenterology Association

    2012     The Heineken Prize for Medicine

    2012     Ridder in de Orde van de Nederlandse Leeuw

    2013     The Breakthrough Prize in Life Sciences

    2014     Massachusetts General Hospital Award in Cancer Research

    2014     TEFAF Oncology Chair 2014

    2014     Fellow of the AACR Academy

    2014     Struyvenberg European Society for Clinical Investigation (ESCI) medal

    2014     National Icon 2014

Research Output (549)

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Verstegen Monique M A, Roos Floris J M, Burka Ksenia, Gehart Helmuth, Jager Myrthe, de Wolf Maaike, Bijvelds Marcel J C, de Jonge Hugo R, Ardisasmita Arif I, van Huizen Nick A, Roest Henk P, de Jonge Jeroen, Koch Michael, Pampaloni Francesco, Fuchs Sabine A, Schene Imre F, Luider Theo M, van der Doef Hubert P J, Bodewes Frank A J A, de Kleine Ruben H J, Spee Bart, Kremers Gert-Jan, Clevers Hans, IJzermans Jan N M, Cuppen Edwin, van der Laan Luc J W 14 dec 2020, In: Scientific Reports. 10 , p. 21900 1 p.

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

Demmers Laura C, Kretzschmar Kai, Van Hoeck Arne, Bar-Epraïm Yotam E, van den Toorn Henk W P, Koomen Mandy, van Son Gijs, van Gorp Joost, Pronk Apollo, Smakman Niels, Cuppen Edwin, Clevers Hans, Heck Albert J R, Wu Wei 1 dec 2020, In: Nature Communications. 11 , p. 5338

Hepatocyte growth factor/MET and CD44 in colorectal cancer:partners in tumorigenesis and therapy resistance

Joosten Sander P.J., Spaargaren Marcel, Clevers Hans, Pals Steven T. dec 2020, In: Biochimica et Biophysica Acta - Reviews on Cancer. 1874 , p. 188437

Human-Derived Model Systems in Gynecological Cancer Research

Lõhmussaar Kadi, Boretto Matteo, Clevers Hans dec 2020, In: Trends in Cancer. 6 , p. 1031-1043 13 p.

Translation and Replication Dynamics of Single RNA Viruses

Boersma Sanne, Rabouw Huib H, Bruurs Lucas J M, Pavlovič Tonja, van Vliet Arno L W, Beumer Joep, Clevers Hans, van Kuppeveld Frank J M, Tanenbaum Marvin E 6 nov 2020, In: Cell. 183 , p. 1930-1945.e23

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Miao Yi, Ha Andrew, de Lau Wim, Yuki Kanako, Santos António J M, You Changjiang, Geurts Maarten H, Puschhof Jens, Pleguezuelos-Manzano Cayetano, Peng Weng Chuan, Senlice Ramazan, Piani Carol, Buikema Jan W, Gbenedio Oghenekevwe M, Vallon Mario, Yuan Jenny, de Haan Sanne, Hemrika Wieger, Rösch Kathrin, Dang Luke T, Baker David, Ott Melanie, Depeille Philippe, Wu Sean M, Drost Jarno, Nusse Roeland, Roose Jeroen P, Piehler Jacob, Boj Sylvia F, Janda Claudia Y, Clevers Hans, Kuo Calvin J, Garcia K Christopher 5 nov 2020, In: Cell stem cell. 27 , p. 840-851.e6

CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids

Hendriks Delilah, Clevers Hans, Artegiani Benedetta 5 nov 2020, In: Cell stem cell. 27 , p. 705-731 27 p.

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

Cho Yong-Hee, Ro Eun Ji, Yoon Jeong-Su, Mizutani Tomohiro, Kang Dong-Woo, Park Jong-Chan, Il Kim Tae, Clevers Hans, Choi Kang-Yell 21 okt 2020, In: Nature Communications. 11 , p. 5321

Establishment of patient-derived cancer organoids for drug-screening applications

Driehuis Else, Kretzschmar Kai, Clevers Hans 1 okt 2020, In: Nature Protocols. 15 , p. 3380-3409 30 p.

Enteroendocrine Dynamics - New Tools Reveal Hormonal Plasticity in the Gut

Beumer Joep, Gehart Helmuth, Clevers Hans 1 okt 2020, In: Endocrine reviews. 41 12 p.

All Research Output (549)