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Researchers

prof. dr. J.C. (Hans) Clevers Full Professor

Molecular Cancer Research
Hubrecht Institute

Contact

jclevers@umcutrecht.nl

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA. From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht and from 2012-2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). His research group is part of the Hubrecht institute.

He is Chevalier de la Legion d'Honneur since 2005 and Knight in the Order of the Netherlands Lion since 2012.

Side Activities

Honorary professorship:

2002 – Honorary professor at Changsha-Hunan, China

Membership:

Member European Molecular Biology Organisation (EMBO)

Member of the Royal Netherlands Academy of Sciences

Member of the International Society for Stem Cell Research (ISSCR)

Member of the Scientific Advisory Board of ISREC, Swiss Institute for Experimental Cancer Research

Member Scientific Committee of the Louis-Jeantet Foundation for Medicine

Member of the American Association for Cancer Research (AACR)

Member of the National Scientific Advisory Board NKI-AVL

Member of the scientific advisory board of “de Anatomische Les”

Member of the Academia Europaea

Member of the Scientific Advisory Board of the MRC Clinical Sciences Centre

Member of the American Academy of Arts and Sciences

Member of the The Royal Holland Society of Sciences and Humanities

Member of the Gairdner Foundation medical advisory board

Foreign Associate of the US National Academy of Sciences

Member of the Scientific advisory committee (SAC) of the Princess Máxima Center for Pediatric Oncology

He is member of a several Editorial Boards, among them are the EMBO Journal, Gastroenterology, Cell and Genes & Development,Cell Stem Cell and the Annual Review of Cancer Biology

Research Output

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance

Duarte Alexandra A., Gogola Ewa, Sachs Norman, Barazas Marco, Annunziato Stefano, R De Ruiter Julian, Velds Arno, Blatter Sohvi, Houthuijzen JM, Van De Ven Marieke, Clevers JC, Borst Piet, Jonkers Jos, Rottenberg Sven 1 Feb 2018 In: Nature Methods. 15, p. 134-140 7 p.

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

Basak O, Krieger Teresa G., Muraro Mauro J., Wiebrands Kay, Stange D.E., Frias-Aldeguer Javier, Rivron Nicolas C., van de Wetering M., van Es J.H., van Oudenaarden A, Simons Benjamin D., Clevers JC 23 Jan 2018 In: Proceedings of the National Academy of Sciences of the United States of America. 115, p. E610-E619

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Sachs Norman, de Ligt J, Kopper Oded, Gogola Ewa, Bounova Gergana, Weeber F, Balgobind Anjali Vanita, Wind Karin, Gracanin Ana, Begthel Harry, Korving Jeroen, van Boxtel R, Duarte Alexandra Alves, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat Marlous, van de Ven Marieke, Egan DA, Zinzalla Vittoria, Moll Jurgen, Boj S.F., Voest EE, Wessels Lodewyk, van Diest PJ, Rottenberg Sven, Vries R.G.J., Cuppen EPJG, Clevers JC 11 Jan 2018 In: Cell. 172, p. 373-386.e10

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures

Jager M, Blokzijl F, Sasselli Valentina, Boymans Sander, Janssen Roel, Besselink Nicolle J M, Clevers JC, van Boxtel R, Cuppen EPJG 1 Jan 2018 In: Nature Protocols. 13, p. 59-78 20 p.

Imaging organoids: A bright future ahead

Rios Anne C., Clevers JC Jan 2018 In: Nature Methods. 15, p. 24-26 3 p.

Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney

Schutgens FWG, Rookmaaker MB, Blokzijl F, van Boxtel R, Vries Robert, Cuppen EPJG, Verhaar MC, Clevers JC 26 Dec 2017 In: Proceedings of the National Academy of Sciences of the United States of America. 114, p. E11190-E11198

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

Artegiani Benedetta, Lyubimova Anna, Muraro Mauro J., van Es J.H., van Oudenaarden A, Clevers JC 12 Dec 2017 In: Cell Reports [E]. 21, p. 3271-3284 14 p.

Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes

Karmouch Jennifer, Zhou Qiong Q., Miyake Christina Y., Lombardi Raffaella, Kretzschmar Kai, Bannier-Hélaouët Marie, Clevers JC, Wehrens Xander H.T., Willerson James T., Marian Ali J. 8 Dec 2017 In: Circulation Research. 121, p. 1346-1359 14 p.

Science Forum: The Human Cell Atlas

Regev Aviv, Teichmann Sarah A., Lander Eric S., Amit Ido, Benoist Christophe, Birney Ewan, Bodenmiller Bernd, Campbell Peter, Carninci Piero, Clatworthy Menna, Clevers JC, Deplancke Bart, Dunham Ian, Eberwine James, Eils Roland, Enard Wolfgang, Farmer Andrew, Fugger Lars, Göttgens Berthold, Hacohen Nir, Haniffa Muzlifah, Hemberg Martin, Kim Seung, Klenerman Paul, Kriegstein Arnold, Lein Ed, Linnarsson Sten, Lundberg Emma, Lundeberg Joakim, Majumder Partha, Marioni John C., Merad Miriam, Mhlanga Musa, Nawijn Martijn, Netea Mihai, Nolan Garry, Pe’er Dana, Phillipakis Anthony, Ponting Chris P., Quake Stephen, Reik Wolf, Rozenblatt-Rosen Orit, Sanes Joshua, Satija Rahul, Schumacher Ton N., Shalek Alex, Shapiro Ehud, Sharma Padmanee, Shin Jay W., Stegle Oliver, Stratton Michael, Stubbington Michael J.T., Theis Fabian J., Uhlen Matthias, van Oudenaarden A, Wagner Allon, Watt Fiona, Weissman Jonathan, Wold Barbara, Xavier Ramnik, Yosef Nir, 5 Dec 2017 In: eLife. 6

WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer

Driehuis Else, Clevers JC 1 Dec 2017 In: British Journal of Pharmacology. 174, p. 4547-4563 17 p.

All Research Output (432)

Fellowship and Awards

2000 Catharijne-prize for medical science

2001 Award from the European Society for Clinical Investigation

2001 Spinoza-award

2004 Louis-Jeantet Prize for Medicine

2005 The Science and Society Prize

2005 The French honor of “Chevalier de la Legion d'Honneur”

2005 Katharine Berkan Judd Award

2006 Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research

2008 Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam)

2008 Meyenburg Cancer Research Award

2009 The Queen Wilhelmina Dutch Cancer Society Award

2010 The United European Gastroenterology Federation (UEGF) Research Prize

2011 The Ernst Jung Medical Award

2011 Kolff prize

2012 Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize

2012 William Beaumont prize of the American Gastroenterology Association

2012 The Heineken Prize for Medicine

2012 Ridder in de Orde van de Nederlandse Leeuw

2013 The Breakthrough Prize in Life Sciences

2014 Massachusetts General Hospital Award in Cancer Research

2014 TEFAF Oncology Chair 2014

2014 Fellow of the AACR Academy

2014 Struyvenberg European Society for Clinical Investigation (ESCI) medal

2014 National Icon 2014