prof. dr. J.C. (Hans) Clevers Full Professor

Molecular Cancer Research
Hubrecht Institute

Contact

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA. From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht and from 2012-2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). His research group is part of the Hubrecht institute.

He is Chevalier de la Legion d'Honneur since 2005 and Knight in the Order of the Netherlands Lion since 2012.

Side Activities

Honorary professorship:

2002 – Honorary professor at Changsha-Hunan, China

Membership:

Member European Molecular Biology Organisation (EMBO)

Member of the Royal Netherlands Academy of Sciences

Member of the International Society for Stem Cell Research (ISSCR)

Member of the Scientific Advisory Board of ISREC, Swiss Institute for Experimental Cancer Research

Member Scientific Committee of the Louis-Jeantet Foundation for Medicine

Member of the American Association for Cancer Research (AACR)

Member of the National Scientific Advisory Board NKI-AVL

Member of the scientific advisory board of “de Anatomische Les”

Member of the Academia Europaea

Member of the Scientific Advisory Board of the MRC Clinical Sciences Centre

Member of the American Academy of Arts and Sciences

Member of the The Royal Holland Society of Sciences and Humanities

Member of the Gairdner Foundation medical advisory board

Foreign Associate of the US National Academy of Sciences

Member of the Scientific advisory committee (SAC) of the Princess Máxima Center for Pediatric Oncology

He is member of a several Editorial Boards, among them are the EMBO Journal, Gastroenterology, Cell and Genes & Development,Cell Stem Cell and the Annual Review of Cancer Biology

Research Output

Oral mucosal organoids as a potential platform for personalized cancer therapy

Driehuis Else, Kolders Sigrid, Spelier Sacha, Lõhmussaar Kadi, Willems Stefan M., Devriese Lot A., de Bree Remco, de Ruiter Emma J., Korving Jeroen, Begthel Harry, van Es Johan H., Geurts Veerle, He Gui Wei, van Jaarsveld Richard H., Oka Rurika, Muraro Mauro J., Vivié Judith, Zandvliet Maurice M.J.M., Hendrickx Antoni P.A., Iakobachvili Nino, Sridevi Priya, Kranenburg Onno, van Boxtel Ruben, Kops Geert J.P.L., Tuveson David A., Peters Peter J., van Oudenaarden Alexander, Clevers Hans 3 May 2019 In: Cancer Discovery. 9, p. 852-871 20 p.

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Kopper Oded, de Witte Chris J, Lõhmussaar Kadi, Valle-Inclan Jose Espejo, Hami Nizar, Kester Lennart, Balgobind Anjali Vanita, Korving Jeroen, Proost Natalie, Begthel Harry, van Wijk Lise M, Revilla Sonia Aristín, Theeuwsen Rebecca, van de Ven Marieke, van Roosmalen Markus J, Ponsioen Bas, Ho Victor W H, Neel Benjamin G, Bosse Tjalling, Gaarenstroom Katja N, Vrieling Harry, Vreeswijk Maaike P G, van Diest Paul J, Witteveen Petronella O, Jonges Trudy, Bos Johannes L, van Oudenaarden Alexander, Zweemer Ronald P, Snippert Hugo J G, Kloosterman Wigard P, Clevers Hans May 2019 In: Nature Medicine. 25, p. 838-849 12 p.

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Bolhaqueiro Ana C F, Ponsioen Bas, Bakker Bjorn, Klaasen Sjoerd J, Kucukkose Emre, van Jaarsveld Richard H, Vivié Judith, Verlaan-Klink Ingrid, Hami Nizar, Spierings Diana C J, Sasaki Nobuo, Dutta Devanjali, Boj Sylvia F, Vries Robert G J, Lansdorp Peter M, van de Wetering Marc, van Oudenaarden Alexander, Clevers Hans, Kranenburg Onno, Foijer Floris, Snippert Hugo J G, Kops Geert J P L May 2019 In: Nature Genetics. 51, p. 824-834 11 p.

Mouse and human urothelial cancer organoids: A tool for bladder cancer research

Mullenders Jasper, de Jongh Evelien, Brousali Anneta, Roosen Mieke, Blom Jan P. A., Begthel Harry, Korving Jeroen, Jonges Trudy, Kranenburg Onno, Meijer Richard, Clevers Hans C. 5 Mar 2019 In: Proceedings of the National Academy of Sciences of the United States of America. 116, p. 4567-4574

Tubuloids derived from human adult kidney and urine for personalized disease modeling

Schutgens Frans, Rookmaaker Maarten B, Margaritis Thanasis, Rios Anne, Ammerlaan Carola, Jansen Jitske, Gijzen Linda, Vormann Marianne, Vonk Annelotte, Viveen Marco, Yengej Fjodor Yousef, Derakhshan Sepide, de Winter-de Groot Karin M, Artegiani Benedetta, van Boxtel Ruben, Cuppen Edwin, Hendrickx Antoni P A, van den Heuvel-Eibrink Marry M, Heitzer Ellen, Lanz Henriette, Beekman Jeffrey, Murk Jean-Luc, Masereeuw Rosalinde, Holstege Frank, Drost Jarno, Verhaar Marianne C, Clevers Hans Mar 2019 In: Nature Biotechnology. 37, p. 303-313 11 p.

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Berkers Gitte, van Mourik Peter, Vonk Annelotte M, Kruisselbrink Evelien, Dekkers Johanna F, de Winter-de Groot Karin M, Arets Hubertus G M, Marck-van der Wilt Rozemarijn E P, Dijkema Jasper S, Vanderschuren Maaike M, Houwen Roderick H J, Heijerman Harry G M, van de Graaf Eduard A, Elias Sjoerd G, Majoor Christof J, Koppelman Gerard H, Roukema Jolt, Bakker Marleen, Janssens Hettie M, van der Meer Renske, Vries Robert G J, Clevers Hans C, de Jonge Hugo R, Beekman Jeffrey M, van der Ent Cornelis K 12 Feb 2019 In: Cell Reports. 26, p. 1701-1708.e3

Long-term expanding human airway organoids for disease modeling

Sachs Norman, Papaspyropoulos Angelos, Zomer-van Ommen Domenique D., Heo Inha, Böttinger Lena, Klay Dymph, Weeber Fleur, Huelsz-Prince Guizela, Iakobachvili Nino, Amatngalim Gimano D., de Ligt Joep, van Hoeck Arne, Proost Natalie, Viveen Marco C., Lyubimova Anna, Teeven Luc, Derakhshan Sepideh, Korving Jeroen, Begthel Harry, Dekkers Johanna F., Kumawat Kuldeep, Ramos Emilio, van Oosterhout Matthijs F.M., Offerhaus G. Johan, Wiener Dominique J., Olimpio Eduardo P., Dijkstra Krijn K., Smit Egbert F., van der Linden Maarten, Jaksani Sridevi, van de Ven Marieke, Jonkers Jos, Rios Anne C., Voest Emile E., van Moorsel Coline H.M., van der Ent Cornelis K., Cuppen Edwin, van Oudenaarden Alexander, Coenjaerts Frank E., Meyaard Linde, Bont Louis J., Peters Peter J., Tans Sander J., van Zon Jeroen S., Boj Sylvia F., Vries Robert G., Beekman Jeffrey M., Clevers Hans 1 Jan 2019 In: EMBO Journal. 38

Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice

Aden Konrad, Bartsch Kareen, Dahl Joseph, Reijns Martin A.M., Esser Daniela, Sheibani-Tezerji Raheleh, Sinha Anupam, Wottawa Felix, Ito Go, Mishra Neha, Knittler Katharina, Burkholder Adam, Welz Lina, van Es Johan, Tran Florian, Lipinski Simone, Kakavand Nassim, Boeger Christine, Lucius Ralph, von Schoenfels Witigo, Schafmayer Clemens, Lenk Lennart, Chalaris Athena, Clevers Hans, Röcken Christoph, Kaleta Christoph, Rose-John Stefan, Schreiber Stefan, Kunkel Thomas, Rabe Björn, Rosenstiel Philip 1 Jan 2019 In: Gastroenterology. 156, p. 145-159.e19

Using Adult Stem Cell-Derived Organoids to Model Neuroendocrine Neoplasms

Dayton T., Den Hartigh L., McFaline J. L., Van Leeuwaarde R., Valk G. D., Van den Berg J., Tesselaar M., Vriens M., Lopes Chuva de Sousa S. M., Fernandez-Cuesta L., Trapnell C., Clevers H. 2019 In: Neuroendocrinology. 108, p. 18-18

Profiling proliferative cells and their progeny in damaged murine hearts

Kretzschmar Kai, Post Yorick, Bannier-Hélaouët Marie, Mattiotti Andrea, Drost Jarno, Basak Onur, Li Vivian S.W., van den Born Maaike, Gunst Quinn D., Versteeg Danielle, Kooijman Lieneke, van der Elst Stefan, van Es Johan H., van Rooij Eva, van den Hoff Maurice J.B., Clevers Hans 26 Dec 2018 In: Proceedings of the National Academy of Sciences of the United States of America. 115, p. E12245-E12254

All Research Output (482)

Fellowship and Awards

2000 Catharijne-prize for medical science

2001 Award from the European Society for Clinical Investigation

2001 Spinoza-award

2004 Louis-Jeantet Prize for Medicine

2005 The Science and Society Prize

2005 The French honor of “Chevalier de la Legion d'Honneur”

2005 Katharine Berkan Judd Award

2006 Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research

2008 Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam)

2008 Meyenburg Cancer Research Award

2009 The Queen Wilhelmina Dutch Cancer Society Award

2010 The United European Gastroenterology Federation (UEGF) Research Prize

2011 The Ernst Jung Medical Award

2011 Kolff prize

2012 Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize

2012 William Beaumont prize of the American Gastroenterology Association

2012 The Heineken Prize for Medicine

2012 Ridder in de Orde van de Nederlandse Leeuw

2013 The Breakthrough Prize in Life Sciences

2014 Massachusetts General Hospital Award in Cancer Research

2014 TEFAF Oncology Chair 2014

2014 Fellow of the AACR Academy

2014 Struyvenberg European Society for Clinical Investigation (ESCI) medal

2014 National Icon 2014