prof. dr. J.C. (Hans) Clevers Full Professor

Molecular Cancer Research
Hubrecht Institute

Contact

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA. From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht and from 2012-2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). His research group is part of the Hubrecht institute.

He is Chevalier de la Legion d'Honneur since 2005 and Knight in the Order of the Netherlands Lion since 2012.

Side Activities

Honorary professorship:

2002 – Honorary professor at Changsha-Hunan, China

Membership:

Member European Molecular Biology Organisation (EMBO)

Member of the Royal Netherlands Academy of Sciences

Member of the International Society for Stem Cell Research (ISSCR)

Member of the Scientific Advisory Board of ISREC, Swiss Institute for Experimental Cancer Research

Member Scientific Committee of the Louis-Jeantet Foundation for Medicine

Member of the American Association for Cancer Research (AACR)

Member of the National Scientific Advisory Board NKI-AVL

Member of the scientific advisory board of “de Anatomische Les”

Member of the Academia Europaea

Member of the Scientific Advisory Board of the MRC Clinical Sciences Centre

Member of the American Academy of Arts and Sciences

Member of the The Royal Holland Society of Sciences and Humanities

Member of the Gairdner Foundation medical advisory board

Foreign Associate of the US National Academy of Sciences

Member of the Scientific advisory committee (SAC) of the Princess Máxima Center for Pediatric Oncology

He is member of a several Editorial Boards, among them are the EMBO Journal, Gastroenterology, Cell and Genes & Development,Cell Stem Cell and the Annual Review of Cancer Biology

Research Output

Oral mucosal organoids as a potential platform for personalized cancer therapy

Driehuis Else, Kolders Sigrid, Spelier Sacha, Lohmussaar Kadi, Willems Stefan M, Devriese Lot A, de Bree Remco, de Ruiter Emma J, Korving Jeroen, Begthel Harry, Van Es Johan H, Geurts Veerle, He Gui-Wei, van Jaarsveld Richard H, Oka Rurika, Muraro Mauro J, Vivie Judith, Zandvliet Maurice M J M, Hendrickx Antoni P A, Iakobachvili Nino, Sridevi Priya, Kranenburg Onno, van Boxtel Ruben, Kops Geert J P L, Tuveson David A, Peters Peter J, van Oudenaarden Alexander, Clevers Hans 3 May 2019 In: Cancer Discovery.

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Berkers Gitte, van Mourik Peter, Vonk Annelotte M, Kruisselbrink Evelien, Dekkers Johanna F, de Winter-de Groot Karin M, Arets Hubertus G M, Marck-van der Wilt Rozemarijn E P, Dijkema Jasper S, Vanderschuren Maaike M, Houwen Roderick H J, Heijerman Harry G M, van de Graaf Eduard A, Elias Sjoerd G, Majoor Christof J, Koppelman Gerard H, Roukema Jolt, Bakker Marleen, Janssens Hettie M, van der Meer Renske, Vries Robert G J, Clevers Hans C, de Jonge Hugo R, Beekman Jeffrey M, van der Ent Cornelis K 12 Feb 2019 In: Cell Reports. 26, p. 1701-1708.e3

Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant article

Van Der Sanden Sabine M.G., Sachs Norman, Koekkoek Sylvie M., Koen Gerrit, Pajkrt Dasja, Clevers Hans, Wolthers Katja C. 1 Dec 2018 In: Emerging Microbes and Infections. 7

Modelling Cryptosporidium infection in human small intestinal and lung organoids

Heo Inha, Dutta Devanjali, Schaefer Deborah A., Iakobachvili Nino, Artegiani Benedetta, Sachs Norman, Boonekamp Kim E., Bowden Gregory, Hendrickx Antoni P.A., Willems Robert J.L., Peters Peter J., Riggs Michael W., O'Connor Roberta, Clevers Hans 1 Jul 2018 In: Nature Microbiology. 3, p. 814-823 10 p.

Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models

Linnekamp Janneke F., Hooff Sander R.Van, Prasetyanti Pramudita R., Kandimalla Raju, Buikhuisen Joyce Y., Fessler Evelyn, Ramesh Prashanthi, Lee Kelly A.S.T., Bochove Grehor G.W., de Jong Johan H., Cameron Kate, Leersum Ronald Van, Rodermond Hans M., Franitza Marek, Nürnberg Peter, Mangiapane Laura R., Wang Xin, Clevers Hans, Vermeulen Louis, Stassi Giorgio, Medema Jan Paul 5 Jan 2018 In: Cell Death and Differentiation. p. 1-18 18 p.

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures

Jager Myrthe, Blokzijl Francis, Sasselli Valentina, Boymans Sander, Janssen Roel, Besselink Nicolle J M, Clevers Hans, Van Boxtel Ruben, Cuppen Edwin 1 Jan 2018 In: Nature Protocols. 13, p. 59-78 20 p.

Imaging organoids: A bright future ahead

Rios Anne C., Clevers Hans Jan 2018 In: Nature Methods. 15, p. 24-26 3 p.

Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney

Schutgens Frans, Rookmaaker Maarten B., Blokzijl Francis, van Boxtel Ruben, Vries Robert, Cuppen Edwin, Verhaar Marianne C., Clevers Hans 13 Dec 2017 In: Proceedings of the National Academy of Sciences of the United States of America. 114, p. E11190-E11198

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Sachs Norman, de Ligt Joep, Kopper Oded, Gogola Ewa, Bounova Gergana, Weeber Fleur, Balgobind Anjali Vanita, Wind Karin, Gracanin Ana, Begthel Harry, Korving Jeroen, van Boxtel Ruben, Duarte Alexandra Alves, Lelieveld Daphne, van Hoeck Arne, Ernst Robert Frans, Blokzijl Francis, Nijman Isaac Johannes, Hoogstraat Marlous, van de Ven Marieke, Egan David Anthony, Zinzalla Vittoria, Moll Jurgen, Boj Sylvia Fernandez, Voest Emile Eugene, Wessels Lodewyk, van Diest Paul Joannes, Rottenberg Sven, Vries Robert Gerhardus Jacob, Cuppen Edwin, Clevers Hans 5 Dec 2017 In: Cell. 172, p. 373-386.e10

Cancer stem cells revisited

Batlle Eduard, Clevers Hans 6 Oct 2017 In: Nature Medicine. 23, p. 1124-1134 11 p.

All Research Output (317)

Fellowship and Awards

2000 Catharijne-prize for medical science

2001 Award from the European Society for Clinical Investigation

2001 Spinoza-award

2004 Louis-Jeantet Prize for Medicine

2005 The Science and Society Prize

2005 The French honor of “Chevalier de la Legion d'Honneur”

2005 Katharine Berkan Judd Award

2006 Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research

2008 Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam)

2008 Meyenburg Cancer Research Award

2009 The Queen Wilhelmina Dutch Cancer Society Award

2010 The United European Gastroenterology Federation (UEGF) Research Prize

2011 The Ernst Jung Medical Award

2011 Kolff prize

2012 Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize

2012 William Beaumont prize of the American Gastroenterology Association

2012 The Heineken Prize for Medicine

2012 Ridder in de Orde van de Nederlandse Leeuw

2013 The Breakthrough Prize in Life Sciences

2014 Massachusetts General Hospital Award in Cancer Research

2014 TEFAF Oncology Chair 2014

2014 Fellow of the AACR Academy

2014 Struyvenberg European Society for Clinical Investigation (ESCI) medal

2014 National Icon 2014