prof. dr. J.C. (Hans) Clevers Full Professor

Molecular Cancer Research
Hubrecht Institute

Contact

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA. From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht and from 2012-2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). His research group is part of the Hubrecht institute.

He is Chevalier de la Legion d'Honneur since 2005 and Knight in the Order of the Netherlands Lion since 2012.

Side Activities

Honorary professorship:

2002 – Honorary professor at Changsha-Hunan, China

Membership:

Member European Molecular Biology Organisation (EMBO)

Member of the Royal Netherlands Academy of Sciences

Member of the International Society for Stem Cell Research (ISSCR)

Member of the Scientific Advisory Board of ISREC, Swiss Institute for Experimental Cancer Research

Member Scientific Committee of the Louis-Jeantet Foundation for Medicine

Member of the American Association for Cancer Research (AACR)

Member of the National Scientific Advisory Board NKI-AVL

Member of the scientific advisory board of “de Anatomische Les”

Member of the Academia Europaea

Member of the Scientific Advisory Board of the MRC Clinical Sciences Centre

Member of the American Academy of Arts and Sciences

Member of the The Royal Holland Society of Sciences and Humanities

Member of the Gairdner Foundation medical advisory board

Foreign Associate of the US National Academy of Sciences

Member of the Scientific advisory committee (SAC) of the Princess Máxima Center for Pediatric Oncology

He is member of a several Editorial Boards, among them are the EMBO Journal, Gastroenterology, Cell and Genes & Development,Cell Stem Cell and the Annual Review of Cancer Biology

Research Output

Automated brightfield morphometry of 3D organoid populations by OrganoSeg

Borten Michael A., Bajikar Sameer S., Sasaki Nobuo, Clevers Hans, Janes Kevin A. 1 Dec 2018 In: Scientific Reports. 8

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice

Grinenko Tatyana, Eugster Anne, Thielecke Lars, Ramasz Beáta, Krüger Anja, Dietz Sevina, Glauche Ingmar, Gerbaulet Alexander, Von Bonin Malte, Basak Onur, Clevers Hans, Chavakis Triantafyllos, Wielockx Ben 1 Dec 2018 In: Nature Communications. 9

Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant article

Van Der Sanden Sabine M.G., Sachs Norman, Koekkoek Sylvie M., Koen Gerrit, Pajkrt Dasja, Clevers Hans, Wolthers Katja C. 1 Dec 2018 In: Emerging Microbes and Infections. 7

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

Hu Huili, Gehart Helmuth, Artegiani Benedetta, LÖpez-Iglesias Carmen, Dekkers Florijn, Basak Onur, van Es Johan, Chuva de Sousa Lopes Susana M., Begthel Harry, Korving Jeroen, van den Born Maaike, Zou Chenhui, Quirk Corrine, Chiriboga Luis, Rice Charles M., Ma Stephanie, Rios Anne, Peters Peter J., de Jong Ype P., Clevers Hans 29 Nov 2018 In: Cell. 175, p. 1591-1606.e19

ROCKin’ Intestinal Cell Fate: A Potential Avenue to Improve Glucose Sensitivity

Beumer Joep, Clevers Hans 1 Oct 2018 In: Gastroenterology. 155, p. 974-976 3 p.

Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology

Sasaki Nobuo, Clevers Hans 1 Oct 2018 In: Current Opinion in Genetics and Development. 52, p. 117-122 6 p.

Establishment and characterization of a canine keratinocyte organoid culture system

Wiener Dominique J., Basak Onur, Asra Priyanca, Boonekamp Kim E., Kretzschmar Kai, Papaspyropoulos Angelos, Clevers Hans 1 Oct 2018 In: Veterinary Dermatology. 29, p. 375-e126

The Myofibroblasts’ War on Drugs

Puschhof Jens, Clevers Hans 24 Sep 2018 In: Developmental Cell. 46, p. 669-670 2 p.

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

Tiriac Hervé et al. 1 Sep 2018 In: Cancer Discovery. 8, p. 1112-1129 18 p.

Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as biomarker of CFTR function

de Winter-de Groot Karin M, Janssens Hettie M, van Uum Rick T, Dekkers Johanna F, Berkers Gitte, Vonk Annelotte, Kruisselbrink Evelien, Oppelaar Hugo, Vries Robert, Clevers Hans, Houwen Roderick H J, Escher Johanna C, Elias Sjoerd G, de Jonge Hugo R, de Rijke Yolanda B, Tiddens Harm A W M, van der Ent Cornelis K, Beekman Jeffrey M 30 Aug 2018 In: European Respiratory Journal. 52

All Research Output (449)

Fellowship and Awards

2000 Catharijne-prize for medical science

2001 Award from the European Society for Clinical Investigation

2001 Spinoza-award

2004 Louis-Jeantet Prize for Medicine

2005 The Science and Society Prize

2005 The French honor of “Chevalier de la Legion d'Honneur”

2005 Katharine Berkan Judd Award

2006 Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research

2008 Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam)

2008 Meyenburg Cancer Research Award

2009 The Queen Wilhelmina Dutch Cancer Society Award

2010 The United European Gastroenterology Federation (UEGF) Research Prize

2011 The Ernst Jung Medical Award

2011 Kolff prize

2012 Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize

2012 William Beaumont prize of the American Gastroenterology Association

2012 The Heineken Prize for Medicine

2012 Ridder in de Orde van de Nederlandse Leeuw

2013 The Breakthrough Prize in Life Sciences

2014 Massachusetts General Hospital Award in Cancer Research

2014 TEFAF Oncology Chair 2014

2014 Fellow of the AACR Academy

2014 Struyvenberg European Society for Clinical Investigation (ESCI) medal

2014 National Icon 2014