dr. L.B. Creemers

dr. L.B. Creemers

Associate Professor



Dr Creemers studied  Biomedical Sciences in Leiden and has worked in several research areas, including spermatogenic stem cells, (periodontal) ligament, tendon and bone. Since 2005 her focus is on cartilage and intervertebral disc research with a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation. Delivery includes small molecules, proteins, peptides and nucleic acids, research approaches involve biological effects, pharmacokinetics and imaging,using  in vitro and in vivo models, the latter in close collaboration with the dept of Companion Animals at the Fac Veterinary Medicine. She is author on over 90 peer-reviewed publications and has in the past years been involved in several projects on local delivery, including BMM IdiDAS (9.2 M€; PI) targeting disc degeneration, BMM-OAcontrol on osteoarthritis and LSH –ArIADNE (1.2 M€;PI), where local delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration is further being taken towards clinical translation. In addition she is involved in H2020 ITN-TargetCaRe on targeted delivery in intervertebral disc and cartilage regeneration.

Side Activities

Chair Science and Research  Committee (Wetenschapscommissie) Division Surgical Specialties UMCU, member International Reviewer panel eCM, member several research organisations (AO, ICRS, OARSI, NVMB, NBTE)

Fellowship and Awards

Co-awardee ‘Mathijsen award’ to R Custers (2011) and KG Auw Yang (2009) by the Dutch Orthopaedic Society for the best PhD thesis

Research Output (159)

Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells

Ma Junxuan, Häne Surya, Eglauf Janick, Pfannkuche Judith, Soubrier Astrid, Li Zhen, Peroglio Marianna, Hoppe Sven, Benneker Lorin, Lang Gernot, Wangler Sebastian, Alini Mauro, Creemers Laura B, Grad Sibylle, Häckel Sonja Jun 2023, In: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 32 , p. 2048-2058 11 p.

Harmonization and standardization of nucleus pulposus cell extraction and culture methods

Basatvat Shaghayegh, Bach Frances C, Barcellona Marcos N, Binch Abbie L, Buckley Conor T, Bueno Brian, Chahine Nadeen O, Chee Ana, Creemers Laura B, Dudli Stefan, Fearing Bailey, Ferguson Stephen J, Gansau Jennifer, Gantenbein Benjamin, Gawri Rahul, Glaeser Juliane D, Grad Sibylle, Guerrero Julien, Haglund Lisbet, Hernandez Paula A, Hoyland Judith A, Huang Charles, Iatridis James C, Illien-Junger Svenja, Jing Liufang, Kraus Petra, Laagland Lisanne T, Lang Gernot, Leung Victor, Li Zhen, Lufkin Thomas, van Maanen Josette C, McDonnell Emily E, Panebianco Chris J, Presciutti Steven M, Rao Sanjna, Richardson Stephen M, Romereim Sarah, Schmitz Tara C, Schol Jordy, Setton Lori, Sheyn Dmitriy, Snuggs Joseph W, Sun Y, Tan Xiaohong, Tryfonidou Marianna A, Vo Nam, Wang Dong, Williams Brandon, Williams Rebecca, Yoon S Tim, Le Maitre Christine L Mar 2023, In: JOR spine. 6

Cell uptake and intracellular trafficking of bioreducible poly(amidoamine) nanoparticles for efficient mRNA translation in chondrocytes

Pontes Adriano P, van der Wal Steffen, Ranamalla Saketh R, Roelofs Karin, Tomuta Ioan, Creemers Laura B, Rip Jaap 2023, In: Frontiers in bioengineering and biotechnology. 11

Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis:a proof of concept in dog patients

Tellegen Anna R, Rudnik-Jansen Imke, Utomo Lizette, Versteeg Sabine, Beukers Martijn, Maarschalkerweerd Roelof, van Zuilen Dick, van Klaveren Nicoline J, Houben Kaat, Teske Erik, René van Weeren P, Karssemakers-Degen Nina, Mihov George, Thies Jens, Eijkelkamp Niels, Creemers Laura B, Meij Björn P, Tryfonidou Marianna A 5 Dec 2022, In: Osteoarthritis and Cartilage. 31 , p. 351-362 12 p.

Polymeric Nanoparticles for Drug Delivery in Osteoarthritis

Pontes Adriano P., Welting Tim J.M., Rip Jaap, Creemers Laura B. Dec 2022, In: Pharmaceutics. 14 , p. 1-25

Intradiscal injection of human recombinant BMP-4 does not reverse intervertebral disc degeneration induced by nuclectomy in sheep

Du Jie, Garcia João P., Bach Frances C., Tellegen Anna R., Grad Sibylle, Li Zhen, Castelein René M., Meij Björn P., Tryfonidou Marianna A., Creemers Laura B. Nov 2022, In: Journal of Orthopaedic Translation. 37 , p. 23-36 14 p.

Hyperosmolar expansion medium improves nucleus pulposus cell phenotype

Laagland Lisanne T., Bach Frances C., Creemers Laura B., Le Maitre Christine L., Poramba-Liyanage Deepani W., Tryfonidou Marianna A. Sep 2022, In: JOR spine. 5 , p. 1-13

PLGA Nanoparticles Grafted with Hyaluronic Acid to Improve Site-Specificity and Drug Dose Delivery in Osteoarthritis Nanotherapy

Zerrillo Luana, Gigliobianco Maria Rosa, D’atri Domenico, Garcia Joao Pedro, Baldazzi Fabio, Ridwan Yanto, Fuentes Gastón, Chan Alan, Creemers Laura B., Censi Roberta, Martino Piera Di, Cruz Luis J. 1 Jul 2022, In: Nanomaterials. 12 , p. 1-17

Extracellular Vesicles from M1-Polarized Macrophages Combined with Hyaluronic Acid and a β-Blocker Potentiate Doxorubicin’s Antitumor Activity by Downregulating Tumor-Associated Macrophages in Breast Cancer

Jorquera-Cordero Carla, Lara Pablo, Cruz Luis J., Schomann Timo, van Hofslot Anna, de Carvalho Thaís Gomes, Guedes Paulo Marcos Da Matta, Creemers Laura, Koning Roman I., Chan Alan B., Junior Raimundo Fernandes de Araujo 17 May 2022, In: Pharmaceutics. 14 , p. 1-17

Intra-articular Administration of Triamcinolone Acetonide in a Murine Cartilage Defect Model Reduces Inflammation but Inhibits Endogenous Cartilage Repair

Wesdorp Marinus A., Capar Serdar, Bastiaansen-Jenniskens Yvonne M., Kops Nicole, Creemers Laura B., Verhaar Jan A.N., Van Osch Gerjo J.V.M., Wei Wu May 2022, In: American Journal of Sports Medicine. 50 , p. 1668-1678 11 p.

All research output

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