dr. L.B. Creemers

dr. L.B. Creemers

Associate Professor
  • Department of Orthopaedics



Dr Creemers studied  Biomedical Sciences in Leiden and has worked in several research areas, including spermatogenic stem cells, (periodontal) ligament, tendon and bone. Since 2005 her focus is on cartilage and intervertebral disc research with a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation. Delivery includes small molecules, proteins, peptides and nucleic acids, research approaches involve biological effects, pharmacokinetics and imaging,using  in vitro and in vivo models, the latter in close collaboration with the dept of Companion Animals at the Fac Veterinary Medicine. She is author on over 90 peer-reviewed publications and has in the past years been involved in several projects on local delivery, including BMM IdiDAS (9.2 M€; PI) targeting disc degeneration, BMM-OAcontrol on osteoarthritis and LSH –ArIADNE (1.2 M€;PI), where local delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration is further being taken towards clinical translation. In addition she is involved in H2020 ITN-TargetCaRe on targeted delivery in intervertebral disc and cartilage regeneration.

Side Activities

Chair Science and Research  Committee (Wetenschapscommissie) Division Surgical Specialties UMCU, member International Reviewer panel eCM, member several research organisations (AO, ICRS, OARSI, NVMB, NBTE)

Fellowship and Awards

Co-awardee ‘Mathijsen award’ to R Custers (2011) and KG Auw Yang (2009) by the Dutch Orthopaedic Society for the best PhD thesis

Research Output (147)

Link-N: The missing link towards intervertebral disc repair is species-specific

Bach Frances C, Laagland Lisanne T, Grant Michael P, Creemers Laura B, Ito Keita, Meij Björn P, Mwale Fackson, Tryfonidou Marianna A 1 Nov 2017, In: PLoS ONE [E]. 12

Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration

Willems Nicole, Mihov George, Grinwis Guy C M, van Dijk Maarten, Schumann Detlef, Bos Clemens, Strijkers Gustav J, Dhert Wouter J A, Meij Björn P, Creemers Laura B. , Tryfonidou Marianna A May 2017, In: Journal of Biomedical Materials Research. Part B, Applied Biomaterials.. 105 , p. 707-714

Bone Morphogenetic Protein-2, but Not Mesenchymal Stromal Cells, Exert Regenerative Effects on Canine and Human Nucleus Pulposus Cells

Bach Frances C., Miranda-Bedate Alberto, Van Heel Ferdi W M, Riemers Frank M., Müller Margot C M E, Creemers Laura B., Ito Keita, Benz Karin, Meij Björn P., Tryfonidou Marianna A. 1 Mar 2017, In: Tissue Engineering. Part A. 23 , p. 233-242 10 p.

Pro-and anti-inflammatory cytokine profiles in osteoarthritis

Bastiaansen-Jenniskens Yvonne, Saris Daniel, Creemers Laura B. 1 Jan 2017, p. 81-97 17 p.

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis

Cai Yunpeng, López-Ruiz Elena, Wengel Jesper, Creemers Laura B, Howard Kenneth A 2017, In: Journal of Controlled Release. 253 , p. 153-159

Prolonged inhibition of inflammation in osteoarthritis by triamcinolone acetonide released from a polyester amide microsphere platform

Rudnik-Jansen Imke, Colen Sascha, Berard Julien, Plomp Saskia, Que Ivo, van Rijen Mattie, Woike Nina, Egas Annelies, van Osch Gerjo, van Maarseveen Erik, Messier Ken, Chan Alan, Thies Jens, Creemers Laura 2017, In: Journal of Controlled Release. 253 , p. 64-72 9 p.

Notochordal-cell derived extracellular vesicles exert regenerative effects on canine and human nucleus pulposus cells

Bach Frances, Libregts Sten, Creemers Laura, Meij Björn P, Ito Keita, Wauben Marca H M, Tryfonidou Marianna A 2017, In: Oncotarget. 8 , p. 88845-88856 12 p.

Derivatization Strategies for the Detection of Triamcinolone Acetonide in Cartilage by Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Barre Florian P. Y., Flinders Bryn, Garcia João P., Jansen Imke, Huizing Lennart R. S., Porta Tiffany, Creemers Laura B., Heeren Ron M. A., Cillero-Pastor Berta 20 Dec 2016, In: Analytical Chemistry. 88 , p. 12051-12059

Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium:Implications for IVD regeneration

Bach F. C., de Vries S. A H, Riemers F. M., Boere J., van Heel F. W M, Goerdayal S. S., van Doeselaar M., Nikkels P. G J, Benz K., Creemers L. B., Maarten Altelaar A. F., Meij B. P., Ito K., Tryfonidou Marianna A. 1 Jul 2016, In: European Cells & Materials. 32 , p. 163-180 18 p.

Early evolving joint degeneration by cartilage trauma is primarily mechanically controlled

Wiegant K., Beekhuizen M., Mastbergen S. C., Kuchuk N. O., Barten-van Rijbroek A. D., Custers R. J H, Saris D. B F, Creemers L. B., Lafeber F. P J G Jun 2016, In: Knee. 23 , p. 487–494

All research output

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