dr. L.B. Creemers

dr. L.B. Creemers

Associate Professor



Dr Creemers studied  Biomedical Sciences in Leiden and has worked in several research areas, including spermatogenic stem cells, (periodontal) ligament, tendon and bone. Since 2005 her focus is on cartilage and intervertebral disc research with a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation. Delivery includes small molecules, proteins, peptides and nucleic acids, research approaches involve biological effects, pharmacokinetics and imaging,using  in vitro and in vivo models, the latter in close collaboration with the dept of Companion Animals at the Fac Veterinary Medicine. She is author on over 90 peer-reviewed publications and has in the past years been involved in several projects on local delivery, including BMM IdiDAS (9.2 M€; PI) targeting disc degeneration, BMM-OAcontrol on osteoarthritis and LSH –ArIADNE (1.2 M€;PI), where local delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration is further being taken towards clinical translation. In addition she is involved in H2020 ITN-TargetCaRe on targeted delivery in intervertebral disc and cartilage regeneration.

Side Activities

Chair Science and Research  Committee (Wetenschapscommissie) Division Surgical Specialties UMCU, member International Reviewer panel eCM, member several research organisations (AO, ICRS, OARSI, NVMB, NBTE)

Fellowship and Awards

Co-awardee ‘Mathijsen award’ to R Custers (2011) and KG Auw Yang (2009) by the Dutch Orthopaedic Society for the best PhD thesis

Research Output (159)

Dog as a Model for Osteoarthritis:The FGF4 Retrogene Insertion May Matter

Tellegen Anna R, Dessing Aileen J, Houben Kaat, Riemers Frank M, Creemers Laura B, Mastbergen Simon C, Meij Björn P, Miranda-Bedate Alberto, Tryfonidou Marianna A 2 Aug 2019, In: Journal of Orthopaedic Research. 37 , p. 2550-2560 11 p.

Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems

Rudnik-Jansen Imke, Woike Nina, de Jong Suzanne, Versteeg Sabine, Kik Marja, Emans Pieter, Mihov George, Thies Jens, Eijkelkamp Niels, Tryfonidou Marianna, Creemers Laura 6 Feb 2019, In: Pharmaceutics. 11

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Garcia João Pedro, Stein Jeroen, Cai Yunpeng, Riemers Frank, Wexselblatt Ezequiel, Wengel Jesper, Tryfonidou Marianna, Yayon Avner, Howard Kenneth A, Creemers Laura B 28 Jan 2019, In: Journal of Controlled Release. 294 , p. 247-258 12 p.

PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation

Rutgers Marijn, Bach Frances, Vonk Luciënne, Akrum Vanessa, van Boxtel Antonette, Dhert Wouter, Creemers Laura 2019, In: PLoS ONE. 14

Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis

Tellegen A. R., Rudnik-Jansen I., Pouran B., de Visser H. M., Weinans H. H., Thomas R. E., Kik M. J. L., Grinwis G. C. M., Thies J. C., Woike N., Mihov G., Emans P. J., Meij B. P., Creemers L. B., Tryfonidou M. A. Nov 2018, In: Drug delivery. 25 , p. 1438-1447 10 p.

Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model

Tellegen A. R., Rudnik-Jansen I., Beukers M., Miranda-Bedate A., Bach F. C., de Jong W., Woike N., Mihov G., Thies J. C., Meij B. P., Creemers L. B., Tryfonidou M. A. 12 Aug 2018, In: Journal of Controlled Release. 286 , p. 439-450 12 p.

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species

Sakai Daisuke, Schol Jordy, Bach Frances C., Tekari Adel, Sagawa Nobuho, Nakamura Yoshihiko, Chan Samantha C.W., Nakai Tomoko, Creemers Laura B., Frauchiger Daniela A., May Rahel D., Grad Sibylle, Watanabe Masahiko, Tryfonidou Marianna A., Gantenbein Benjamin Jun 2018, In: JOR spine. 1

Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix:From bench towards bedside

Bach Frances C., Tellegen Anna R., Beukers Martijn, Miranda-Bedate Alberto, Teunissen Michelle, de Jong Willem A.M., de Vries Stefan A.H., Creemers Laura B., Benz Karin, Meij Björn P., Ito Keita, Tryfonidou Marianna A. 29 May 2018, In: Oncotarget. 9 , p. 26507-26526 20 p.

Intradiscal application of a PCLA–PEG–PCLA hydrogel loaded with celecoxib for the treatment of back pain in canines:What's in it for humans?

Tellegen Anna R., Willems Nicole, Beukers Martijn, Grinwis Guy C.M., Plomp Saskia G.M., Bos Clemens, van Dijk Maarten, de Leeuw Mike, Creemers Laura B., Tryfonidou Marianna A., Meij Björn P. 1 Mar 2018, In: Journal of Tissue Engineering and Regenerative Medicine. 12 , p. 642-652 11 p.

Comparing Hydrogels for Human Nucleus Pulposus Regeneration:Role of Osmolarity during Expansion

Krouwels Anita, Melchels Ferry, Van Rijen Mattie H P, Oner F Cumhur, Dhert Wouter, Tryfonidou M, Creemers Laura 17 Feb 2018, In: Tissue engineering. Part C, Methods. 24 , p. 222-232 11 p.

All research output

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