dr. L.B. Creemers
dr. L.B. Creemers
Research Programs
Biography
Biography
Dr Creemers studied Biomedical Sciences in Leiden and has worked in several research areas, including spermatogenic stem cells, (periodontal) ligament, tendon and bone. Since 2005 her focus is on cartilage and intervertebral disc research with a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation. Delivery includes small molecules, proteins, peptides and nucleic acids, research approaches involve biological effects, pharmacokinetics and imaging,using in vitro and in vivo models, the latter in close collaboration with the dept of Companion Animals at the Fac Veterinary Medicine. She is author on over 90 peer-reviewed publications and has in the past years been involved in several projects on local delivery, including BMM IdiDAS (9.2 M€; PI) targeting disc degeneration, BMM-OAcontrol on osteoarthritis and LSH –ArIADNE (1.2 M€;PI), where local delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration is further being taken towards clinical translation. In addition she is involved in H2020 ITN-TargetCaRe on targeted delivery in intervertebral disc and cartilage regeneration.
Side Activities
Chair Science and Research Committee (Wetenschapscommissie) Division Surgical Specialties UMCU, member International Reviewer panel eCM, member several research organisations (AO, ICRS, OARSI, NVMB, NBTE)
Fellowship and Awards
Co-awardee ‘Mathijsen award’ to R Custers (2011) and KG Auw Yang (2009) by the Dutch Orthopaedic Society for the best PhD thesis
Research Output (159)
Tellegen Anna R, Dessing Aileen J, Houben Kaat, Riemers Frank M, Creemers Laura B, Mastbergen Simon C, Meij Björn P, Miranda-Bedate Alberto, Tryfonidou Marianna A 2 Aug 2019, In: Journal of Orthopaedic Research. 37 , p. 2550-2560 11 p.
Rudnik-Jansen Imke, Woike Nina, de Jong Suzanne, Versteeg Sabine, Kik Marja, Emans Pieter, Mihov George, Thies Jens, Eijkelkamp Niels, Tryfonidou Marianna, Creemers Laura 6 Feb 2019, In: Pharmaceutics. 11
Garcia João Pedro, Stein Jeroen, Cai Yunpeng, Riemers Frank, Wexselblatt Ezequiel, Wengel Jesper, Tryfonidou Marianna, Yayon Avner, Howard Kenneth A, Creemers Laura B 28 Jan 2019, In: Journal of Controlled Release. 294 , p. 247-258 12 p.
Rutgers Marijn, Bach Frances, Vonk Luciënne, Akrum Vanessa, van Boxtel Antonette, Dhert Wouter, Creemers Laura 2019, In: PLoS ONE. 14
Tellegen A. R., Rudnik-Jansen I., Pouran B., de Visser H. M., Weinans H. H., Thomas R. E., Kik M. J. L., Grinwis G. C. M., Thies J. C., Woike N., Mihov G., Emans P. J., Meij B. P., Creemers L. B., Tryfonidou M. A. Nov 2018, In: Drug delivery. 25 , p. 1438-1447 10 p.
Tellegen A. R., Rudnik-Jansen I., Beukers M., Miranda-Bedate A., Bach F. C., de Jong W., Woike N., Mihov G., Thies J. C., Meij B. P., Creemers L. B., Tryfonidou M. A. 12 Aug 2018, In: Journal of Controlled Release. 286 , p. 439-450 12 p.
Sakai Daisuke, Schol Jordy, Bach Frances C., Tekari Adel, Sagawa Nobuho, Nakamura Yoshihiko, Chan Samantha C.W., Nakai Tomoko, Creemers Laura B., Frauchiger Daniela A., May Rahel D., Grad Sibylle, Watanabe Masahiko, Tryfonidou Marianna A., Gantenbein Benjamin Jun 2018, In: JOR spine. 1
Bach Frances C., Tellegen Anna R., Beukers Martijn, Miranda-Bedate Alberto, Teunissen Michelle, de Jong Willem A.M., de Vries Stefan A.H., Creemers Laura B., Benz Karin, Meij Björn P., Ito Keita, Tryfonidou Marianna A. 29 May 2018, In: Oncotarget. 9 , p. 26507-26526 20 p.
Tellegen Anna R., Willems Nicole, Beukers Martijn, Grinwis Guy C.M., Plomp Saskia G.M., Bos Clemens, van Dijk Maarten, de Leeuw Mike, Creemers Laura B., Tryfonidou Marianna A., Meij Björn P. 1 Mar 2018, In: Journal of Tissue Engineering and Regenerative Medicine. 12 , p. 642-652 11 p.
Krouwels Anita, Melchels Ferry, Van Rijen Mattie H P, Oner F Cumhur, Dhert Wouter, Tryfonidou M, Creemers Laura 17 Feb 2018, In: Tissue engineering. Part C, Methods. 24 , p. 222-232 11 p.