dr. O.L. (Olaf) Cremer Associate Professor

Intensive Care Medicine

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Infection & Immunity

Biography
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Biography

Olaf Cremer (1971) was trained as an anesthesiologist, intensivist and clinical epidemiologist. He has worked as a full-time staff member in the department of intensive care medicine of the UMCU since 2007. Dr. Cremer has designed and co-developed the patient data management system that is currently in use. His detailed knowledge of the system and computer programming skills allow him to explore this clinical database as a rich source of information for several research projects within the division.
Dr. Cremer obtained his PhD degree in 2005 with a doctoral thesis on goal-directed management of patients with severe traumatic brain injury. His thesis included both experimental clinical studies focused on cerebrovascular pathophysiology, as well as large cohort studies focused on patient outcomes. Since 2008 he has been studying the clinical epidemiology of infections in the ICU. To this aim, dr. Cremer is the clinical PI of the MARS (Molecular Diagnosis and Risk Stratification in Sepsis) study, an ongoing multicenter project aiming to develop and validate new technologies for early diagnosis and prognostication in sepsis. Within this study framework, he focuses on the modeling of outcomes and complications of severe sepsis with adjustment for competing risks and time-dependent covariates. He currently is (or has been) mentoring 9 PhD students.

Research Output

The host response in critically ill sepsis patients on statin therapy: a prospective observational study

Wiewel Maryse A., Scicluna Brendon P., van Vught Lonneke A., Hoogendijk Arie J., Zwinderman Aeilko H., Lutter René, Horn Janneke, Cremer Olaf L., Bonten Marc J., Schultz Marcus J., van der Poll Tom 1 Dec 2018 In: Annals of Intensive Care. 8 12 p.

Iron metabolism in critically ill patients developing anemia of inflammation: a case control study

Boshuizen Margit, Binnekade Jan M., Nota Benjamin, van de Groep Kirsten, Cremer Olaf L., Tuinman Pieter R., Horn Janneke, Schultz Marcus J., van Bruggen Robin, Juffermans Nicole P., de Beer Friso M., Bos Lieuwe D.J., Glas Gerie J., van Hooijdonk Roosmarijn T.M., Schouten Laura R.A., Straat Marleen, Witteveen Esther, Wieske Luuk, Hoogendijk Arie J., Huson Mischa A., Scicluna Brendon P., van der Poll Tom, van Vught Lonneke A., Wiewel Maryse A., Bonten Marc J.M., Frencken Jos F., Klein Klouwenberg Peter M.C., Koster-Brouwer Maria E., Ong David S.Y., Verboom Diana M., 1 Dec 2018 In: Annals of Intensive Care. 8 8 p.

Uncertainty in Diagnosis Leads to Underestimates of Performance Reply

Koster-Brouwer Maria E., Verboom Diana M., Bonten Marc J. M., Cremer Olaf L. Aug 2018 In: Critical Care Medicine. 46, p. E820-E821

Development and first evaluation of a novel multiplex real-time PCR on whole blood samples for rapid pathogen identification in critically ill patients with sepsis

van de Groep Kirsten, Bos Martine P, Savelkoul Paul H M, Rubenjan Anna, Gazenbeek Christel, Melchers Willem J G, van der Poll Tom, Juffermans Nicole P, Ong David S Y, Bonten Marc J M, Cremer Olaf L, 26 Apr 2018 In: European Journal of Clinical Microbiology & Infectious Diseases. 37, p. 1333-1344

The ability of intensive care unit physicians to estimate long-term prognosis in survivors of critical illness

Soliman Ivo W., Cremer Olaf L., de Lange Dylan W., Slooter Arjen J.C., van Delden Johannes (Hans) J.M., van Dijk Diederik, Peelen Linda M. 1 Feb 2018 In: Journal of Critical Care. 43, p. 148-155 8 p.

Myocardial Injury in Patients with Sepsis and Its Association with Long-Term Outcome

Frencken Jos F., Donker Dirk W., Spitoni Cristian, Koster-Brouwer Marlies E., Soliman Ivo W., Ong David S.Y., Horn Janneke, Van Der Poll Tom, Van Klei Wilton A., Bonten Marc J.M., Cremer Olaf L. 1 Feb 2018 In: Circulation. Cardiovascular Quality and Outcomes. 11

Associations Between Enteral Colonization With Gram-Negative Bacteria and Intensive Care Unit-Acquired Infections and Colonization of the Respiratory Tract

Frencken Jos F, Wittekamp Bastiaan H J, Plantinga Nienke L, Spitoni Cristian, van de Groep Kirsten, Cremer Olaf L, Bonten Marc J M 1 Feb 2018 In: Clinical Infectious Diseases. 66, p. 497-503 7 p.

Reply to Lipcsey

Ong David S Y, Bonten Marc J M, Cremer Olaf L 18 Jan 2018 In: Clinical Infectious Diseases. 66, p. 482

Development and Validation of an Abbreviated Questionnaire to Easily Measure Cognitive Failure in ICU Survivors: A Multicenter Study

Wassenaar Annelies, de Reus Jorn, Donders A Rogier T, Schoonhoven Lisette, Cremer Olaf L., De Lange Dylan W., Van Dijk Diederik, Slooter Arjen J.C., Pickkers Peter, Van Den Boogaard Mark 1 Jan 2018 In: Critical Care Medicine. 46, p. 79-84 6 p.

Validation of a novel molecular host response assay to diagnose infection in hospitalized patients admitted to the ICU with acute respiratory failure

Koster-Brouwer Maria E., Verboom Diana M., Scicluna Brendon P., Van De Groep Kirsten, Frencken Jos F., Janssen Davy, Schuurman Rob, Schultz Marcus J., Van Der Poll Tom, Bonten Marc J.M., Cremer Olaf L. 1 Jan 2018 In: Critical Care Medicine. 46, p. 368-374 7 p.

All Research Output (131)

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